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Ovos Natural Health, Vivimind, 60 tabs - VIVIMIND provides homotaurine, an amino acid naturally found in seaweed and clinically found to support the region of the brain called the hippocampus, which plays a vital role in learning and memory.
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Ovos Natural Health, Vivimind, 60 tabs

VIVIMIND - 60 tabs
Vivimind
Ovos Natural Health, Vivimind, 60 tabs is manufactured by Ovos Vivimind

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Since VIVIMIND has been formally approved by Health Canada, changes to the claims, dosage and risk information were required. It is common that once a product is approved by Health Canada, these types of changes occur.

Ingredients

For French, see the link at the bottom right corner of the page

Medicinal Ingredients
 
Homotaurine (3-amino-1-propanesulfonic acid)  50 mg
 
Non-medicinal ingredients: microcrystalline cellulose, dibasic calcium phosphate, ethyl cellulose, glycerol, hypromellose, magnesium stearate, medium chain triglycerides, oleic acid, polydextrose, pregelatinized starch, sodium alginate, stearic acid, magnesium silicate, titanium dioxide, and maltodextrin.

OVOS NATURAL HEALTH™ guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, dairy, soy, eggs, fish, shellfish or any animal byproduct.

NEW HEALTH CANADA - APPROVED VIVIMIND LABEL

Dosage form:
Enteric Coated Tablet

Recommended route of administration:
Oral

Recommended dose:
Adults (50 years and older): Take 2 tablets twice a day with food, or as directed by a qualified health care practitioner. Do not crush, blend or mix the tablets. Swallow the tablets whole.

Recommended duration of use:
N/A

Recommended use or purpose:
Homotaurine has been investigated in pre-clinical and early clinical studies. Those studies suggest that VIVIMIND™ may help support the specific area of the brain known as the hippocampus. This effect has not been studied in a healthy population. This product is not intended to treat, prevent, or reduce the risk of any specific diseases.

Risk Information:

Cautions
Some people may experience nausea, weight loss, dizziness or fainting. Do not exceed recommended daily dose as you may experience more of these symptoms.

Contra-Indications

  • If you experience any weight loss, drowsiness, dizziness, fainting, persistent nausea, vomiting, or diarrhea, consult a health-care practitioner.
  • Consumption of homotaurine with alcohol, other medications and/or natural health products with sedative properties is not recommended.
  • Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness.
  • Discontinue use if you experience any confusion or any unexpected memory loss.
  • Do not use if you are diagnosed with stomach ulcers or low blood pressure or if you are pregnant, planning on becoming pregnant, or breast-feeding.
  • Consult a health care practitioner if you have any questions.

FACTS
 

  • VIVIMIND™ was subjected to over 15 years of significant scientific research, including clinical testing in over 2,000 individuals in Canadian, American and European medical centres.
  • In a large, randomized, double-blind, placebo-controlled clinical phase III study carried out with 1,052 individuals in Canada and the U.S., VIVIMIND™ was shown to reduce hippocampal volume loss in Alzheimer’s disease patients by 68% over 18 months. That information is reported by Gauthier S. et al, in the Journal of Nutrition, Health & Aging, 2009; 13 (6): 550-7, a peer-reviewed scientific journal.
  • The hippocampus is a brain region responsible for memory and learning.

1Health Canada states that the duration of use is not applicable (N/A) because the efficacy of the product is shown over time. The duration of the treatment is to be determined by the consumer.

Clinical studies show that homotaurine reduced shrinking of the hippocampus by 68% over 18 months and enhanced cognitive performance such as thinking, learning and memory by 33% over 12 months. Experts believe that VIVIMIND works by providing protection against amyloid-β-induced neurotoxicity. VIVIMIND has been clinically studied for 15 years in over 2,000 individuals and has been found to significantly reduce the symptoms of cognitive decline related to aging.
  • Protects the hippocampus
  • Enhances learning and memory
  • Helps prevent cognitive decline
For an aging population, VIVIMIND represents a breakthrough in one of the key consequences of getting older – memory loss. VIVIMIND is a science-based natural health product that has been shown to protect memory function based on the naturally occurring ingredient, homotaurine, found in seaweed.

What makes VIVIMIND™ a new generation memory protection solution? Putting it simply, there is no comparable product in the marketplace today. VIVIMIND is different from other natural health solutions because it is:

  • Supported by over 15 years of combined rigorous scientific research including clinical testing with over 2,000 individuals(1).
  • The first nutraceutical to undergo such in-depth evaluation in large state-of-the-art clinical trials in the field of cognition.


Over 18 months Homotaurine reduces the loss of hippocampal volume by 68% compared to placebo.

Homotaurine showed a 33% better result in cognitive performance tests (ADAS-cog) vs. placebo at 12 months.

A major groundbreaking study performed in Canada and the United States using brain scans (magnetic resonance imaging (MRI)), showed that homotaurine, the active ingredient in VIVIMIND™, can protect the hippocampus, the portion of the brain associated with a person’s ability to learn and remember, by showing that homotaurine reduces the loss of volume by 68 per cent when compared to placebo (like a sugar pill)(2).

Individuals taking VIVIMIND™ also performed better on tests of memory and thinking compared with individuals taking placebo. VIVIMIND™ was found to improve cognitive performance by 33% versus the placebo (like a sugar pill)(2).

  1. North American and European phase 3 clinical trials – data on file BELLUS Health.
  2. Post-hoc analysis of a 78-week Phase III North American study in 1052 mild-to-moderate Alzheimer’s disease patients 50 and older.

As we age, certain brain regions start to shrink. This shrinkage reflects loss of brain cells. One brain region in which brain cell loss occurs is the hippocampus, a region responsible for learning and memory. Shrinkage of the hippocampus has been associated with learning and memory problems(2).

Why does the loss of brain cells in the hippocampal region occur?
Experts believe that the buildup of certain toxic proteins(3-4) called beta-amyloid (or A-beta) is detrimental to the brain. When these proteins reach excessive levels, they cause neurons (brain cells) within the brain to malfunction and die. When neurons are damaged or die, signaling problems occur in the brain that ultimately affect memory and learning abilities(3).

VIVIMIND™ is a patented product based on the naturally occurring ingredient homotaurine, which binds to A-beta proteins and reduces the deposition and toxic effects of these proteins in the brain(4). In a groundbreaking study performed in Canada and the United States using brain scans (magnetic resonance imaging (MRI)), VIVIMIND™ was shown to significantly reduce the loss of brain volume in the hippocampus. In fact, VIVIMIND™ was proven to preserve 68% more brain volume versus placebo (like a sugar pill)(5).

Individuals taking VIVIMIND™ also performed better on memory and thinking tests compared with individuals taking placebo. VIVIMIND™ was found to improve cognitive performance (verbal skills, memory, comprehension ability, planning and execution skills) by 33% versus placebo(5).

What is the safety profile?
While VIVIMIND is generally well tolerated at the recommended dose, some people may experience nausea, weight loss, dizziness or fainting. In many cases, symptoms are temporary. If they persist, contact your healthcare professional.

Can VIVIMIND be used with other natural products or medications?
Metabolism studies suggest that interactions between VIVIMIND and other products are not likely to occur(6). No specific interaction studies were conducted with other products. For further information, contact your healthcare professional.

  1. North American and European phase 3 clinical trials – data on file BELLUS Health.
  2. The Johns Hopkins White Papers. Rabins PV, MEMORY Johns Hopkins Medicine, Baltimore, Maryland, 2008.
  3. Aisen PS et al. A Phase II study targeting amyloid-β with 3APS in mild-to-moderate Alzheimer disease. Neurology 2006;67:1757-1763. http://www.neurology.org/cgi/content/full/67/10/1757.
  4. Gervais F et al. Targeting soluble Aβ peptide with Tramiprosate for the treatment of brain amyloidosis. Neurobiology of Aging 2007; (28):536-547.
  5. Post-hoc analysis of a 78-week Phase III North American study in 1052 mild-to-moderate Alzheimer’s disease patients 50 and older.
  6. Metabolism studies – data on file BELLUS Health.

1. What is VIVIMIMD?

For an aging population, VIVIMIND represents a breakthrough in one of the key consequences of getting older - memory loss. VIVIMIND is a science-based natural health product that has been scientifically proven to protect memory function based on the naturally occurring ingredient, homotaurine, found in seaweed. VIVIMIND:

  • Protects the brain structure associated with memory and learning
  • Preserves memory
  • Sustains brain cell health
  • Maintains verbal skills and comprehension ability
  • Supports planning and execution skills
2. Is VIVIMIND  an extract of the natural form of homotaurine found in seaweed?

No. The active ingredient in VIVIMIND™ is a synthetic form of homotaurine, which is chemically and biologically identical to the natural compound. Extracts are generally close to 100% pure, which means an extract of homotaurine would contain nothing but homotaurine. The chemically synthesized form of homotaurine is also a 100% pure extract. Think of it as a lock and key concept: homotaurine is the key that will fit the lock, which is a cellular receptor in the hippocampus region of the brain. As long as the key has the same structure, it will fit the lock. Therefore, homotaurine, whether a natural extract or chemically synthesized, it will have the same effect.

3. Is homotaurine the same thing as taurine?

No. Homotaurine and taurine are two different compounds that belong to the same chemical family but have different origins and effects. Taurine is a major constituent of digestive fluids produced by the liver (bile). Taurine can be found in small amounts in the tissues of many animals including humans. Homotaurine does not convert into taurine after digestion and vice versa. Homotaurine has shown a protective effect on brain cells, while taurine has no protective effect.

4. How does VIVIMIND  work?

As we age, certain brain regions start to shrink. This shrinkage reflects loss of brain cells. One brain region in which brain cell loss occurs is the hippocampus, a region responsible for learning and memory. Shrinkage of the hippocampus has been associated with learning and memory problems2.

Why does the loss of brain cells in the hippocampal region occur? Scientific research indicates that the buildup of certain toxic proteins3-4 called beta-amyloid (or A-beta) is detrimental to the brain. When these proteins reach excessive levels, they cause neurons (brain cells) within the brain to malfunction and die. When neurons are damaged or die, signaling problems occur in the brain that ultimately affect memory and learning abilities3.

Research has shown that VIVIMIND protects brain cells by two mechanisms: it reduces the accumulation of toxic Aβ proteins, which can deposit as plaques in the brain. VIVIMIND also protects brain cells from the toxic effects of the Aβ proteins and thus reduces brain cell toxicity, damage and death, in part through activation of brain cell receptors, called GABAa receptors, in an area of the brain associated with learning and memory (the hippocampus).

VIVIMIND is a patented product based on the naturally occurring ingredient homotaurine, which binds to A-beta proteins and reduces the deposition and toxic effects of these proteins in the brain4.

In a groundbreaking study performed in Canada and the United States using brain scans (magnetic resonance imaging (MRI)), VIVIMIND™ was shown to significantly reduce the loss of brain volume in the hippocampus. In fact, VIVIMIND was proven to preserve 68% more brain volume versus placebo (like a sugar pill)5.

Individuals taking VIVIMIND also performed better on memory and thinking tests compared with individuals taking placebo. VIVIMIND™ was found to improve cognitive performance (verbal skills, memory, comprehension ability, planning and execution skills) by 33% versus placebo5.

VIVIMIND has been shown to:

  • Protect the brain structure associated with memory and learning
    • The hippocampus is a brain region associated with learning and memory. VIVIMIND™ can help reduce the loss of volume of this very important region through the aging process.
       
  • Preserve memory
    • You know how you can be introduced to someone and forget their name two minutes later? VIVIMIND™ can support you in maintaining your ability to remember things like people’s names.
       
  • Sustain brain cell health
    • As you age, it is normal to lose brain cells. VIVIMIND can help protect your brain cells during the normal course of aging.
       
  • Maintain verbal skills and comprehension ability
    • VIVIMIND can help you maintain your level of verbal comprehension and your overall quality of speech. So when you are telling a story or making a presentation, VIVIMIND™ can help you retain your train of thought.
       
  • Support planning and execution skills
    • You have just arrived at your vacation destination and you suddenly realize that you forgot to cancel your newspaper subscription. VIVIMIND™ can help you maintain your ability to go from the initial planning to remember everything you need to make it a trip you will never forget.

5. What is the recommended dosage for VIVIMIND?

Each tablet of VIVIMIND contains 50 mg of homotaurine. VIVIMIND tablets should be taken daily and should be swallowed whole (not crushed, blended or mixed) since the enteric coating allows for better absorption. The recommended adult dose (18 years of age and older) is 1 to 2 tablets twice a day (in the morning and evening). It is recommended to take VIVIMIND with meals. If you miss a dose, do not worry; simply start again the next day at your regular time. Do not double the dose to make up for the missed dose.

6. What result should I expect to see, or experience after taking VIMIND?

Taking VIVIMIND is like taking a vitamin. Essentially healthy individuals in adulthood, who are concerned about possible memory loss, will be protecting their memory. Consider it as an insurance policy for the brain. Much like you buy house, car and life insurance based on what may happen, you will equally take VIVIMIND™ based on what may happen.

7. Is VIVIMIND  safe?

After hundreds of millions of dollars invested and 15 years of rigorous scientific research, including clinical testing with over 2,000 individuals1 in 68 European, 50 U.S. and 17 Canadian medical centres, VIVIMIND is now available for consumers. The product has been shown to be safe and generally well tolerated at the recommended daily dose. Some people may experience symptoms such as nausea, weight loss, dizziness or fainting. The recommended dose should not be exceeded, since people may experience more of these symptoms. It should be noted that from what we have seen in the scientific data to date, certain symptoms such as nausea, are generally transient and normally subside by themselves with consistent use. If they persist, contact your health care practitioner.

 8. Can VIMIND be used with other natural products or medications?

Metabolism studies suggest that interactions between VIVIMIND and other products are not likely to occur6. No specific interaction studies were conducted with other products. For further information, contact your healthcare professional.



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