- DNA Repair, Cardiocascular (Arteriosclerosis)
- Preventing Macular Eye Degeneration
- Type II diabetes
- Total Body Detox
- Effective In Treating Helicobacter Pylori
- Restores Skin Integrity (beauty from within)
- Hormone Balancing (for women)
- Immune system support.
Sulforaphane Glucosinolate (SG), also referred to as Glucoraphanin, is a
naturally occurring compound in cruciferous vegetables. It is found in
brussel sprouts, kale, cauliflower, kohlrabi and even wasabi but is
highest in broccoli, specifically seeds and sprouts. (SG content
declines significantly as the broccoli plant matures).
BroccoGen 10 is
from a non-GMO source that has been specially bred through traditional
farming techniques to have up to 300 times more SG than has been
measured before. BroccoGen 10™ has 10% Sulforaphane Glucosinolate
(Glucoraphanin) content and holds 10 patents.
For SG to be beneficial to
the body, it must first be converted into the compound "Sulforaphane"
which is classified as an "Isothiocyanate" (chemical group). One of the
ways this is accomplished is through interaction with the microflora in
the intestinal tract (1,2). Once sulforaphane is present in the body, it
has a number of health benefits including activating protective
proteins like NRF2 (a transcription factor that helps control DNA
information transfer). It is also considered a monofunctional inducer
which means it can induce the beneficial Phase II Enzymes while not
affecting the potentially dangerous Phase I Enzymes (3) (Phase I Enzymes
can actually activate a carcinogen in the body which may cause genetic
damage before it can be detoxified from the body by Phase II Enzymes.)
It is one of the most potent naturally occurring inducers of Phase II
Enzymes that help with the body's natural defense system.
act as indirect antioxidants by supporting continuous and long lasting
antioxidant reactions in the body, even after the Sulforaphane is no
longer present (up to 72 hours), promoting cellular integrity and
repairing DNA damage from things like ROS (Reactive Oxygen Species),
chemicals, viruses and radiation - the four main contributing factors to
DNA break down which is the carcinogenesis that leads to cancer. This
carcinogenesis (DNA Breaking Down) can take up to 15 or 20 years before
the tumor arrives.
Sulforaphane has even been shown to act as an
antibacterial against Helicobacter pylori, a strain commonly associated
with gastritis and peptic ulcers and that also dramatically increases
the risk of gastric cancer (4). Helicobacter pylori has been categorized
as a class one carcinogen by the World Health Organization as a cause
for stomach cancer (5). BroccoGen 10™ is truly Broccoli's most powerful
total-body wellness nutrient.
Each capsule contains:
Sprout Concentrate (Brassica oleracea italica)*……………….300mg *min 6%
Sulforaphane Glucosinolate (Glucoraphanin)
Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate and
capsule containing vegetable cellulose and water.
Dose: As a dietary supplement, take 1 – 2 Veggie Caps per day with a
meal or as directed by your health care practitioner.
Caution: Do not
use if pregnant or breastfeeding. If you are on medication, consult a
health care practitioner before using.
Keep out of reach of children. Sealed for your protection. Do
not use if seal is broken. Contains no artificial color, sweeteners,
soy, yeast, wheat, gluten, corn, milk, eggs, shellfish or preservatives.
Oxidative stress and inflammation can be contribut¬ing factors in chronic degenerative diseases of the eye such as cataracts and age-related macular degeneration. Sulforaphane has been shown to protect specific eye cells (retinal pigment epithelial cells) from oxidative injury through the induction of Phase II Genes (6) and also reduce retinal light damage by inducing Thioredoxin (7), a protective protein, making sulforaphane a promising treatment strategy for eye diseases due to oxidative stress.
Cardiovascular System Benefits:
Oxidative stress can be a causal factor of such conditions as Hypertension (High Blood Pressure) and Atherosclero¬sis, a form of arteriosclerosis in which there is hardening of the artery caused specifically by a build up of fatty material like cholesterol. An increase in oxidants or free radicals can decrease the nitric oxide needed for smooth muscle function and also increases inflammation which can lead to the previously mentioned conditions. Sulforaphane has been shown to decrease oxidative stress and reduce inflammation in the cardiovascular system and a 2004 study concluded: “a diet containing phase 2 protein induc¬ers also reduces the risk of developing cardiovascular problems of hypertension and atherosclerosis”. (8)
Breast cancer is the most common cancer diagnosed in women today and the second most common cancer in the world. In clinical studies, Sulforaphane has been shown to be an effective inhibitor of human mammary carcinoma proliferation and it also now appears to affect human breast cancer promotion/progression by disrupting the cancer cell replication methods. (10)
Lung cancer is the most common cancer in the world today with a low survival rate and the risk of developing lung cancer is higher in smokers than in non-smokers. Studies have shown that isothiocyanates like sulforaphane "are known to reduce lung carcino¬genesis by tobacco-related carcinogens" (13) by reducing DNA damage. This particular study conduded that there is additional evidence that isothiocyanates from cruciferous vegetables protect against lung cancer. (13)
There are many known causes of urinary/bladder cancer including tobacco smoke and some industrial petroleum-based chemicals. Certain pharmaceuticals and not drinking enough water can also be contributing factors. Conclusions from a num¬ber of studies show that isothiocyanates from cruciferous vegetables can protect against bladder cancer (16). It is believed the contributing factor is the increase in Phase II Enzymes and the fact that isothiocyanate metabolites are water soluble and excreted through the urinary system giving the bladder high exposure.
Prostate cancer is one of the leading causes of male cancer death. It is characterized by anzyme. Sulforaphane has been found to "induce Phase II Enzyme expression and activity significantly in human prostatic cells" (14). This and other study results may provide the expla¬nation for the correlation between high consumption of cruciferous vegetables and decreased prostate cancer risk.
Sulforaphane's main involvement in cancer is by inducing Phase II Enzymes which help to detoxify carcinogens from the body by making them more easily excreted as well as to help stabilize cell replication and decrease inflammation. Sulforaphane has shown significant effects on a number of forms of cancer including Breast, Colon, Leukemia, Lung, Prostate, Urinary/Bladder and skin among others.
Leukemia is cancer of the blood or bone marrow and is characterized by abnormal production of blood cells. Sulforaphane has been shown to induce apoptosis (programmed cell death) and also obstruct proliferation in cancer cells. An in vitro study concluded that sulforaphane showed "potent inhibition of leukemic cell growth" and it "deserves study as a potential chemopreventive/chemotherapeutic antileukemic agent". (12)
Colon cancer is a prevalent cancer among both men and women, especially in western societies. Small doses of Sulforaphane have been shown in an in vitro study to induces apoptotic death in human colon cancer cells (11) providing a promising strategy for the treatment and prevention of colon cancer
Skin cancer is one of the most diagnosed yet treatable types of cancer if caught early, but the incidence is increasing. UV radiation damages DNA indirectly by causing oxidative stress. It also increases inflammation in the skin (including erythema and edema), and also causes immunosuppression. Sulforaphane has been found to provide "direct protection against the pathophysiological effects of UVR in human skin" (15). Topical application will compliment internal supplementation by delivering Sulforaphane directly to the skin. Newco has two topical products for this purpose: DNA Repair Ointment and DNA Repair & Protect Lotion.*
*Please note these two products do not have an SPF factor and are to be used after UV exposure, not in place of proper SPF protection.
1 Getachun , S.M., Chung, F.L. (May 1999). “Conversion of Glucosinolates to Isothiocyanates in Humans after Ingestion of Cooked Watercress”. Cancer, Epidemiology, Biomarkers & Prevention, vol. 8, pp. 447-451.
2 Shapiro, T.A., Fahey, J.W., Wade, K.L., Stephenson, K.K., Talalay, P. (December 1998). “Human Metabolism and Excretion of Cancer Chemoprotective Glucosinolates and Isothiocyanates of Cruciferous Vegetables”. Can¬cer, Epidemiology, Biomarkers & Prevention, vol. 7, pp. 1091-1100.
3 “Backgrounder: The Phase I – Phase II Enzyme System: A Delicate Balance”. Brassica Protection Products LLC. http://www.brassica.com/sci.ph12backgnd.htm (20 August, 2009)
4 Fahey, J.W., Haristoy, X., Dolan, P.M., Kensler, T.W., Scholtus, I., Stephenson, K.K., Talalay, T., Lozniewski, A. (May 2002). “Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors”. Proceedings of the National Academy of Sciences, vol. 99, issue 11, pp. 7610-7615.
5 Talalay, M.D., Paul, “Protection Against Cancer and Chronic Degenerative Diseases: Plants, Genes, and En¬zymes”. The Cancer Project’s 2006 Cancer & Nutrition Symposium, Bethesda, MD. 22 July 2006.
6 Cano, M. del V., Reyes, J.M., Park, C Y., Gao, X., Mori, K., Chuck, R.S., Gehlbach, P.L. (June 2008). “Demonstration by Redox Fluorometry that Sulforaphane Protects Retinal Pigment Epithelial Cells against Oxida¬tive Stress”. Investigative Ophthalmology & Visual Science, vol. 49, issue 6, pp. 2606-2612.
7 Tanito, M., Masutani, H., Kim, Y.C., Nishikawa, M., Ohira, A., Yodoi, J. (March 2005). “Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice”. Investi¬gative Ophthalmology & Visual Science, vol. 26, issue 3, pp. 979-987.
8 Wu, L., Hossein Noyan Ashraf, M., Facci, M., Wang, R., Paterson, P.G., Ferrie, A., Juurlink, B.H.J. (May 2004). “Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system”. Proceedings of the National Academy of Sciences, vol. 101, issue 18, pp. 7094-7099.
9 Xue, M., Qian, Q., Adaikalakoteswari, A., Rabbani, N., Babaei-Jadidi, R., Thornalley, P.J. (October 2008). “Activation of NF-E2-Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hypergly¬cemia Linked to Vascular Disease”. Journal Diabetes, vol. 57, issue 10, pp. 2809-2817.
10 Jackson, W.J.T., Singletary, K.W. (June 2004). “Sulforaphane Inhibits Human MCH-7 Mammary Cancer Cell Mitotic progression and Tubulin Polymerization”. The Journal of Nutrition, vol. 134, pp. 2229-2236.
11 Kirlin, W.G., Cai, J., DeLong, M.J., Patten, E.J., Jones, D.P. (July 1999). “Dietary Compounds That Induce Cancer Preventive Phase 2 Enzymes Activate Apoptosis at Comparable Doses in HT29 colon Carcinoma Cells”. The Journal of Nutrition, vol. 129, pp. 1827-2835.
12 Fimognari, C., Nusse, M., Cesari, R., Iori, R., Cantelli-Forti, G., Hrelia, P. (2002). “Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane”. Carcinogenesis, vol. 23, issue 4, pp. 581-586.
13 Zhao, B., Seow, A., Lee, E.J.D., Poh, W.T., The, M., Eng, P., Wang, Y.T., Tan, W.C., Yu, M.C., Lee, H.P. (October 2001). “Dietary Isothiocyanates, Glutathione S-transferase -M1, -T1, Polymorphisms and Lung Cancer Risk among Chinese Women in Singapore”. Cancer, Epidemiology, Biomarkers & Prevention, vol. 10, pp. 1063- 1067.
14 Brooks, J.D., Paton, V.G., Vidanes, G. (September 2001). “Potent Induction of Phase 2 Enzymes in Human Prostate Cells by Sulforaphane”. Cancer, Epidemiology, Biomarkers & Prevention, vol. 10, pp. 949-954.
15 Talalay, P., Fahey, J.W., Healy, Z.R., Wehage, S.L., Benedict, A.L., Min, C., Dinkova-Kostova, A.T. (October 2007). “Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation”. Proceedings of the National Academy of Sciences, vol. 104, issue 44, pp. 17500-17505.
16 Zhao, H., Lin, J., Grossman, H.B., Hernandez, L.M., Dinney, C P., We, X. (2007). “Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk”. International Journal of Cancer, vol., 120, pp. 2208-2213.
17 Myzak, M.C., Dashwood, R.H. (February 2006). “Chemoprotection by sulforaphane: Keep one eye beyond Keap1”. CancerLetters, vol. 233, issue 2, pp. 208-218.