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AOR, AOR Zymes, 100 caps - AOR-Zymes is a mixture of pancreatic enzymes including lipases, proteases, amylases as well as alpha galactosidase for assisting in digestion of fats, proteins and carbohydrates. Alpha galactosidase helps breakdown and assists in absorption of legumes. Su
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AOR, AOR Zymes, 100 caps

AOR Zymes - 100 caps
Zymes - 100 caps, aor vitamins supplements
AOR, AOR Zymes, 100 caps is manufactured by AOR Supplements

Last updated on 12/5/2016

AOR Zymes

  • Improves and Enhances Digestion
  • Improves Nutrient Absorption
  • Helps Reduce Inflammation

Porcine derived pancreatic enzymes are far more effective in the assimilation of food than plant-derived enzymes because they are more similar to human pancreatic enzymes. AOR Zymes is a digestive aid that helps reduce gas production and flatulence following a meal rich in fermentable carbohydrates such as vegetables, legumes and whole grains. AOR Zymes helps prevent gastrointestinal intolerance of fermentable carbohydrates.

NPN Product Code Size Per Capsule Vegetarian
80037351 AOR04109 100 Vegi-Caps 516 mg NO
166 mg
Supplement Facts
Serving Size: 1 Capsule


Porcine Pancreatic Enzymes 166 mg
Amylase Min. 20,750 USP Units
Lipase Min. 1,660 USP Units
Protease Min. 20,750 USP Units
Alpha Galactosidase 350 mg (350 GalU*)

*FCC-approved units. Non-medicinal ingredients: silicon dioxide, dicalcium phosphate, microcrystalline cellulose, lactose (from milk). Capsule: gellan gum, hypromellose.

• TO ASSURE FRESHNESS AND POTENCY, STORE TIGHTLY CLOSED IN A COOL, DRY, DARK PLACE •

Note: Product appearance, odor and taste may vary due to the use of natural ingredients. In keeping with our highest standards, no masking agents have been used to alter product characteristics.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, eggs, fish or shellfish.

Adult Dosage: Take 1 capsule immediately before a meal one to four times daily, or as directed by a qualified health care practitioner. Use the smallest effective dose which controls symptoms. Swallow whole; do not open capsules.

Cautions: Consult a health care practitioner for prolonged use, for use beyond 4 weeks, or prior to use if you have diabetes, pancreatitis, pancreatic exocrine insufficiency or cystic fibrosis. Do not use if you are sensitive to pancreatic enzymes or pork proteins. Nausea, vomiting, abdominal pain/epigastric pain, heartburn, and/or hypersensitivity/allergy have been known to occur, in which case discontinue use and consult a health care practitioner. If symptoms persist or worsen, discontinue use and consult a health care practitioner.

Pregnancy/Nursing: Consult a health care practitioner

Source:
Pig pancreas from Denmark

Main Indications:

  • Digestion
  • Gastrointestinal health
  • Inflammation

Research

Why Enzymes?
The main application for digestive enzymes is to improve digestion. Enzymes increase absorption and help in the breakdown of food into nutrients. If you want to get more out of your food and improve your digestion, digestive enzymes are a good idea. They promote health in general by enhancing nutrient utilization; they spare digestive organs, may play a role in inflammation and could speed up recovery time. The ability of digestive enzymes at improving digestibility and enhancing nutrient absorption has clearly been demonstrated. They also appear to have anti-inflammatory effects and may speed up tissue repair and recovery.

Enzymes and Digestion
The main metabolites found in the food we eat are proteins, lipids and carbohydrates. They are essential to life and they are the only source of energy for our body. Like all nutrients, we must extract them from our food. The enzymes we produce during digestion allow this process to occur. Protease, lipase and amylase are the enzymes required to break down proteins, lipids and carbohydrates respectively. They are catabolic enzymes because they break and cleave larger molecules into particles that can be absorbed and utilized by our body. In order to make use of the nutrients found in the food we eat, we must digest them. Digestion is a metabolic process that requires considerable resources. Indeed, large portions of the proteins we absorb are used to support digestion and repair and replenish the cells of the gastrointestinal tract. Most cells found in the organs of the gastrointestinal tract have a very rapid turnover time. Likewise, a lot of energy is required for digestion. Enzymatic supplementation is especially helpful at increasing the efficiency of the digestive process, improving absorption and sparing the organs of digestion.

Digestion and Aging
As we age, we become less efficient at digesting our food. Gradual loss of function of the secretory mucosa of the stomach affects 25% of adults in their 60′s and 40% of those over 80. Liver function also declines with age. Our capacity to produce digestive enzymes is reduced and our ability to extract nutrients from the food we eat suffers. Digestive enzymes help offset this detrimental change. Adding enzymes to your diet allows for a more complete digestion and improves nutrient absorption. Animal trials confirm better nutrient utilization with enzyme supplementation.

Proteases
Protease enzymes cleave proteins found in food into individual amino acids. Enzymes responsible for the breakdown of proteins such as protease are found in all cells and tissues because they degrade and remove unwanted proteins. They are thought to reduce inflammation because of their role in the breakdown of useless proteins.

Lipase
Lipase breaks down fats to glycerol and fatty acids. The first step in fat utilization is the hydrolysis of triacylglycerol (stored fat) by lipases. Patients who cannot digest lipids because of pancreatic insufficiency usually receive supplemental porcine lipase.

Alpha Amylase
Alpha Amylase is the animal enzyme responsible for the breakdown of starches to simple sugars. Starch is the nutritional reservoir for plants and is present in two forms: amylose and amylopectin. More than half the carbohydrates ingested by humans are starches. Amylase is released by the salivary glands and by the pancreas. Amylase cleaves starch into maltose, maltotriose and alpha-dextrin.

Alpha Galactosidase
Alpha Galactosidase, found in AOR-Zymes, is the enzyme responsible for the breakdown of non-digestable oligosaccharides normally found in legumes but that cannot be broken down in the small intestine. Without the presence of the enzyme, these polysaccharides enter the large intestine and are broken down by bacteria. This results in the production of gas, bloating and general discomfort. The addition of Alpha Galactosidase allows for the digestion of the culprit polysaccharides. This is especially interesting for anybody consuming soy-containing products because galactooligosaccharides, rafffinose and stachyose, all found in soy, cannot be digested without alpha galactosidase.

Human Studies

In humans, pancreatic enzymatic supplementation is used for patients with cystic fibrosis because of pancreatic insufficiency.

Lipase
Patients with cystic fibrosis usually need to supplement their diet with lipase because they cannot digest fat properly. Pancreatic enzyme replacement therapy leads to normalized lipase function in 40% of the patients.  Porcine lipase has been the treatment of choice for steatorrhea due to pancreatic exocrine deficiency for several decades.

Protease
It appears that some enzymes also exhibit healing properties. A recent study in runners demonstrated that protease supplementation leads to superior recovery and diminished delayed-onset muscle soreness after running. Proteases may also facilitate muscle healing after exercise. Studies have shown that surgical wounds from patients receiving oral enzymatic preparations healed more rapidly than wounds in control populations.

Liprotamase is an enzyme clinically used in Europe for treating exocrine pancreatic insufficiency in cystic fibrosis patients from 7 years of age and older. In a phase III clinical trial, Liprotamase, which contains lipase, protease and amylase, was found to increase both fat absorption and nitrogen absorption (a marker of protein absorption) by an average of about 10%, decrease stool weight meaning that more food was absorbed, and was well tolerated. An extended trial found that the use of up to 5 capsules per day over 1 year was also safe and well-tolerated by most.

Animal Studies

Many studies involving digestive enzymes are done on animals for a simple reason; stockbreeders are interested in enzymes because if they can increase the efficiency of nutrient assimilation in their animals, they spend less on feed.

In ducks, protein absorption increased by 2% with the addition of enzymes. In a study done on hens, enzymatic support augmented nutrient availability and enhanced gut morphology. Supplementation promotes healthier digestive organs by facilitating digestion. Turkeys given digestive enzymes had superior feed efficiency and longer villus in the jejunum. Longer villi increase the absorptive surface in the intestinal tract, which facilitates and improves growth. Unhealthy and atrophied villus results in malnutrition and increased intestinal permeability. Enzyme supplementation clearly leads to improved nutrient availability in animal studies performed on broilers, hens, turkeys, ducks and pigs.

Alpha Amylase
In pigs, enzymatic supplementation increased starch and non-starch polysaccharide digestibility by 7.5%.

Market Trends

Due to the growing awareness of gut health, digestive issues and nutrient content in foods and how these relate to chronic conditions, digestive enzymes are increasing in popularity.

Enzymes have also been used in clinical settings in European countries for decades to improve surgery recovery.

Market trends for using enzymes to reduce inflammation, for tissue repair, for joint health and for heart health are increasing.

AOR Advantage

AOR Zymes utilizes porcine pancreatic enzymes because their composition is similar to human digestive enzymes. They are therefore superior to vegetable enzymes and benefit a longer historical use.

References

Borowitz D, Stevens C, Brettman LR, Campion M, Chatfield B, Cipolli M; Liprotamase 726 Study Group.  International phase III trial of liprotamase efficacy and safety in pancreatic-insufficient cystic fibrosis patients. J Cyst Fibros. 2011 Dec;10(6):443-52.

Borowitz D, Stevens C, Brettman LR, Campion M, Wilschanski M, Thompson H; Liprotamase 767 Study Group. Liprotamase long-term safety and support of nutritional status in pancreatic-insufficient cystic fibrosis. J Pediatr Gastroenterol Nutr. 2012 Feb;54(2):248-57.

Layer P, Keller J. Lipase supplementation therapy: standards, alternatives, and perspectives. Pancreas. 2003 Jan;26(1):1-7. Review.

Meng X, Slominski BA, Guenter W. The effect of fat type, carbohydrase, and lipase addition on growth performance and nutrient utilization of young broilers fed wheat-based diets. Poult Sci. 2004 Oct;83(10):1718-27.

Miller PC, Bailey SP, Barnes ME, Derr SJ, Hall EE. The effects of protease supplementation on skeletal muscle function and DOMS following downhill running. J Sports Sci. 2004 Apr;22(4):365-72.

Ritz CW, Hulet RM, Self BB, Denbow DM. Growth and intestinal morphology of male turkeys as influenced by dietary supplementation of amylase and xylanase. Poult Sci. 1995 Aug;74(8):1329-34.


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