Suggested Use
Take one to four softgels daily with a fat-containing meal, or as directed by a qualified health care practitioner. If you are concerned about maintaining healthy blood lipid balance, combine with a diet low in saturated fats.

Main Applications
As reported by literature:
Antioxidant.
Cardiovascular disease.
Anticarcinogens.
Healthy blood lipids.

Source
Palm.

Pregnancy / Nursing
No studies have been conducted. Best to avoid.

Cautions
Possible interaction with Warfarin (Coumadin). Vitamin E complex may "thin" the blood. Consult with a physician if you are using anticoagulants or if you have clotting problems.


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Copyright 2005, Advanced Orthomolecular Research 

Cholesterol Reduction

Inhibit cholesterol production in the liver, thereby lowering total blood cholesterol.

Alpha tocotrienol suppresses hepatic HMG-CoA reductase activity that results in the lowering of LDL cholesterol levels.

Tocotrienols which are naturally occurring in palm oil, have been shown to suppress / lower plasma cholesterol in human.

Combination of gamma-tocotrienol and alpha-tocopherol is found as a potential hypolipemic agent in hyperlipemic humans at atherogenic risk.

Tocotrienols inhibit cholesterogenesis by suppressing HMG-CoA reductase.

Reversing Carotid Atherosclerosis

Reverses arterial blockage (carotid atherosclerosis), hence reducing the risk factors for cardio-vascular diseases such as atherosclerosis and stroke. Palm based tocotrienol is the first and natural compound to be shown by human study to have the ability to reverse atherosclerosis.

Medical human research showed that patients with confirmed carotid atherosclerosis, who consumed 240mg of palm based tocotrienol complex per day for 18-36 months had a decrease in the amount of cholesterol plaque in their carotid artery while those receiving placebo did not show such an effect.

Palm based tocotrienol complex protects the ApoE knockout mice against cholesterol build-up and hence prevent arteriosclerosis.

Protection Against Ischemia/Reperfusion Heart Injury

Medical study suggests that palm based tocotrienols were more efficient than alpha-tocopherol alone in the protection of the heart against oxidative stress induced by ischemic reperfusion.

Inhibit of Platelet Aggregation

Delta-tocotrienol was significantly more potent than the alpha and gamma-tocotrienols, in the inhibition of platelet aggregation.

Palm based tocotrienols may serve as an antithrombotic agent by decreasing platelet aggregation significantly.

Most Cardioprotective

Based on new scientific publication on tocotrienol and cardioprotection - gamma-tocotrienol is the most potent for cardioprotection. (AJP Heart and Circulatory Physiology).

Neuroprotection

Based on on-going NIH-funded study and in collaboration with the Ohio State University Medical Center - Prof. Chandan Sen has published 5 peer-reviewed papers which proved that alpha-tocotrienol is the most potent in preventing stroke-induced injuries to the brain.

Anti-cancer and Tumour Suppresive

Palm based tocotrienols had shown to inhibit human breast cancer cells irrespective of estrogen receptor status. Tocopherol has no effect at all on human breast cancer cells.

Delta - tocotrienol was found to be the most effective tocotrienols in inducing apoptosis (cell death) in estrogen-responsive and estrogen-nonresponsive human breast cancer cells.

Confer anti-cancer properties.

Inhibit tumor growth of certain cancers.

Alpha-tocotrienol and gamma-tocotrienol have shown to prolong the life span of cancer-infected mice.

Gamma-tocotrienol is 3 times more potent in inhibiting growth of human breast cancer cultured cells than Tamoxifen.

Published research from the East Tennessee University and MD Anderson Cancer Center (Texas) revealed that gamma-tocotrienol was the most potent in inhibiting prostate cancer cells.

Potent Natural Super - Antioxidant

Alpha-tocotrienol has been shown to be 40 - 60 times more potent than alpha-tocopherol as an antioxidant in the prevention of lipid peroxidation.

Effective antioxidant in the prevention of protein oxidation and lipid peroxidation after strenous exercise for athletes, joggers and body builders.

Anti - Aging / Cosmetics and Personal Care

Preferentially accumulates at the stratum corneum of the skin. First line of defense against free radicals generated in the skin by UV/ozone rays. Prevention of skin aging and damage by oxidative rays. Being a more potent antioxidant, the tocotrienols neutralizes free radicals at a faster rate and hence protect tocopherols.

Protection against UV-induced skin damage and skin aging.

Tocotrienols topically applied onto the skin was found to penetrate rapidly through the skin and the highest concentrations are found in the uppermost 5 microns.

Tocotrienol-treated skin contained Vitamin E at concentration 7-30 fold higher than control values.

Tocotrienol augments the efficacy of sunscreens containing compounds that reduce penetration of or absorb ultraviolet radiation.

Lower Blood Pressure

Palm gamma-tocotrienol has ability to prevent development of increased blood pressure in Spontaneously Hypertensive Rats (SHR) after 3 months supplementation.