AOR Ribogen Mg contains magnesium which helps in the maintenance of proper muscle function and in tissue formation. Magnesium also helps in the metabolism of fats, proteins and carbohydrates, and in the development and maintenance of bones and teeth, and is a factor in the maintenance of good health.
| NPN
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Product Code
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Weight
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Vegetarian
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| 80026971
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AOR04276
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263 g Powder
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100% Vegetarian
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| Supplement Facts
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| Serving Size: 1 scoop (~2.5 grams)
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| Magnesium (from Mg citrate)
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20 mg
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| Non-medicinal ingredients: D-Ribose (2.5g)
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AOR guarantees that no ingredients not listed on
the label have been added to the product. Contains no wheat, gluten,
corn, nuts, dairy, soy, eggs, fish, shellfish, or any animal byproduct.
Suggested Use
Take 1 scoop one to four times per day with/without food, or as directed by a qualified health care practitioner.
Pregnancy / Nursing
Safe if used as directed
Main Application:
Helps maintain proper muscle function
A PIVOTAL ROLE IN ATP
D-ribose, sometimes known simply as ribose, is a naturally occurring,
five-carbon sugar that is found in all living cells. It can be
synthesized endogenously from glucose and is essential to the
functioning of life, as it is a component of all forms of ribonucleic
acid (RNA), adenosine triphosphate (ATP), as well as all nucleotides and
nucleotide coenzymes. RNA is the single richest source of D-ribose, and
D-ribose from RNA is converted to D-deoxyribose, a component of DNA
(Deoxyribonucleic acid), the building block of life itself
When combined with D-ribose, the pervasive purine adenine (a
central base of nucleotides) forms adenosine, which in turn amalgamates
three phosphate molecules to form adenosine triphosphate (ATP). ATP is
known as the ‘molecular currency' of intracellular energy transfer,
providing energy for every move and chemical reaction made by the body.
ATP generates energy when it is hydrolyzed, causing one or two of its
phosphate molecules to break off, releasing large amounts of energy.
When one phosphate molecule breaks off, the remaining compound becomes
adenosine diphosphate, or ADP. With the release of a second phosphate
molecule, the resulting compound is AMP, or adenosine monophosphate. In
order to properly regulate its energy reserves, the cell must maintain a
certain ratio of ATP, ADP, and AMP nucleotides. However, under
conditions of stress - particularly cardiac ischemia - the cell is
simply unable to generate ATP fast enough. This leads to an initially
disproportionate amount of ADP and AMP, and if ATP levels continue to be
depleted, the cell initiates something of an emergency measure known as
the myokinase reaction. This is when two ADP nucleotides are combined
to form one ATP nucleotide and one AMP nucleotide, which although
satisfies at least some of the demand for ATP, also results in a buildup
of already disproportionate levels of AMP. In order to restore balance,
AMP must be degraded to simpler end products and flushed out of the
cell. This results in a dramatic decline in adenine nucleotide pools -
up to 50% following heart muscle ischemia - and requires several days or
longer for a return to baseline levels, resulting in significantly
prolonged recovery times. The inability of the heart and skeletal muscle
cells to replenish their nucleotide pools quickly enough is due in
large part to the inefficient metabolism of endogenous ribose needed for
ATP nucleotide re-synthesis.
PHARMACOKINETIC MECHANISM OF ACTION
The body
produces endogenous ribose from glucose mainly via the Pentose Phosphate
Pathway (PPP), and this is a lengthy and complex process involving
rate-limiting enzymes, particularly glucose-6-phosphate dehydrogenase
(G-6-PD). Supplemental D-ribose bypasses the G-6-PD reaction and is
expediently converted by the PPP into D-ribose-5-phosphate and then to
5-Phosphoribosyl 1-pyrophosphate (PRPP), which is the active form of
D-ribose utilized by the body. The latter is critical in the de novo
synthesis and salvage pathways of purine nucleotide formation as well as
in the synthesis of pyrimidine and L-histidine nucleotides.
Supplemental D-ribose can therefore serve as a precursor for PRPP,
enhancing its nucleotide synthesizing and salvaging capability - with
ATP being among the primary nucleotides being synthesized and salvaged.
Supplemental oral D-ribose is also extremely bio-available, with
88-100% being absorbed directly from the small intestine with very
little first-pass metabolism occurring in the liver. It is then
distributed to various tissues of the body, including cardiac and
skeletal muscle, where phosphorylation by the PPP (and to a lesser
extent through glycolysis and other pathways) takes place.
D-ribose and Cardiovascular Ischemia
The
effectiveness of D-ribose has been demonstrated in the gold standard of
scientific study; double-blind, placebo-controlled human trials. In one
study of 20 men (aged 45 to 69) with severe documented coronary artery
disease (CAD) and a history of angina induced by normal daily
activities, 60 grams of D-ribose (in four doses of 15 grams each) were
tested against a placebo. Treated subjects exhibited improvement as
measured electrocardiographically, and time to onset of moderate angina
(during exercise testing) increased significantly in the ribose-treated
subjects. The authors concluded: "In patients with CAD, administration
of ribose by mouth for three days improved the heart's tolerance to
ischemia. The presumed effects on cardiac energy metabolism offer new
possibilities for adjunctive medical treatment of myocardial ischemia."
In another study involving 15 patients with coronary heart disease and
congestive heart failure, it was found that 15 grams of D-ribose daily
for three weeks resulted in improved diastolic heart function as well as
increased scores in physical function and quality of life.
D-ribose and Fibromyalgia/Chronic Fatigue Syndrome
Fybromyalgia
(FMS) and Chronic Fatigue Syndrome (CFS) are debilitating conditions
that have been diagnosed with increasing frequency, especially since the
late 1980's. The aforementioned role of D-ribose in the composition and
generation of ATP has led to the hypothesis that it may be of
assistance to patients suffering from these conditions. Scientists put
this hypothesis to the test in 2006 when 41 patients diagnosed with FMS
and/or CFS were given 15 grams of D-ribose daily for 19 days. The
results were that 66% of the patients experienced ‘significant
improvement' in all five categories of a standardized Visual Analogue
Scale questionnaire (VAS): energy; sleep; mental clarity; pain
intensity; and well-being. The patients experienced an average increase
of 45% in energy and 30% in well-being.
D-ribose and Exercise
D-ribose also has benefits
for healthy people who are in need of extra energy. A double blind,
placebo-controlled trial observed the effects of supplemental ribose on
body composition and exercise performance. 20 healthy, young male
recreational bodybuilders aged 18-35 were given 10g/day D-ribose (5g
before and after training) for 4 weeks. Training involved participation
in a heavy-resistance program designed to increase skeletal muscle mass.
There was a significant increase in the total work performed and in
1-RM bench press strength at the end of the study compared to the
beginning in the D-ribose group. These changes were not seen in the
placebo group, leading researchers to conclude that the supplementation
contributed to increases in muscular strength and exercise performance.
D-ribose
is extremely well-tolerated in human trials, and its fundamental role
in the make-up and synthesis of ATP continues to attract interest from
the scientific community for the study of an increasing number of health
conditions affected by energy metabolism.
D-ribose is a naturally occurring, five-carbon sugar found in all living cells. It is a component of adenosine triphosphate (ATP), ribonucleic acid (RNA), and all nucleotides and nucleotide coenzymes. Studies show that ribose can alleviate fatigue associa
AOR Supplements & Vitamins
SKU Number: AOR04276
On Sale - AOR Supplements
UPC 0062491704276