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AOR, Co-Q10, 100mg, 60 caps - Co-Enzyme Q10 (CoQ10) is an essential factor in the production of cellular energy in the mitochondria, and is a powerful fat-soluble network antioxidant. Extensive research demonstrates that CoQ10 supports healthy cardiovascular function.
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AOR, Co-Q10, 100mg, 60 caps

AOR Coenzyme Q10 100mg - 60 vcaps
Coenzyme Q10 100mg - 60 vcaps, aor vitamins supplements
AOR, Co-Q10, 100mg, 60 caps is manufactured by AOR Supplements

Last updated on 12/5/2016

Co-Enzyme Q10

  •  Powerful antioxidant
  •  Supports cardiovascular function
  •  Alleviates symptoms of congestive heart failure

Co-Enzyme Q10 (CoQ10) is an essential factor in the production of cellular energy in the mitochondria, and is a powerful fat-soluble network antioxidant. Extensive research demonstrates that CoQ10 supports healthy cardiovascular function.

NPN Product Code Size Per Capsule Vegetarian
02159589 AOR04244 60 Vegi-Caps 100 mg Vegetarian
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving

Co-Enzyme Q10 (ubiquinone-10) 100 mg

Non-medicinal ingredients: silicon dioxide, anhydrous dibasic calcium phosphate. Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, dairy, soy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage: Take 1 to 3 capsule daily, with a fat containing meal, or as directed by a qualified health care practitioner.

Cautions: Consult a health care practitioner prior to use if you are taking blood pressure medication or blood thinners.

Pregnancy/Nursing: Consult a health care practitioner prior to use.

Source:
Fermentation of sugar beets

Main Indications:

  • Heart conditions
  • Periodontal disease
  • Immune disorders
  • Cancer
  • Blood sugar control

Research

Background Information

What is CoQ10?
CoQ10 is a fat-soluble, crystalline compound with a Molecular weight of 338.44 Daltons. Co Q10 functions as a co-enzyme in the energy-producing metabolic pathways of every cell of the body with a powerful antioxidant activity.

Co-enzyme Q10 (Co-Q10) is a Vitamin-like substance that is found in virtually all cells of the human body, thus earning CoQ10 its other name, ubiquinone. In 1957, Dr. Fred L Carne noticed a frothy substance that consistently rose to the top of the test tubes of meshed beef heart. This yellow crystalline substance was identified by Karl Folkers (the “father” of Co enzyme Q10) at the Merck, Sharp & Dohme laboratories in New Jersey in 1958. Dr. R.A. Morten called this Q10 compound ubiquinone because of its widespread appearance in living organisms. Unlike vitamins, which by definition are not synthesized within the body, CoQ10 is synthesized in nearly every tissue of the body. It is also, in fact, not a vitamin at all but rather a co-enzyme – an organic molecule that activates a larger protein catalyst (an enzyme) that in turn facilitates a biological reaction without extinguishing itself within that reaction. Co-enzyme Q10 has a quinone-like group (hence the Q) with 10 isoprenoid units as the side-chain (hence the 10). Quinones are molecules that serve as electron receptors in essential biological functions such as photosynthesis and respiration. CoQ10′s quinone ring is synthesized from the amino acid tyrosine whilst the isoprenoid side chains are formed from acetyl CoA (of which pantethine is also a precursor). CoQ10 is very similar in structure to Vitamin K and Vitamin E, although its role is quite different.

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Biological functions
The fact that Co-Q10 is able to accept electrons in such a ubiquitous manner means that it can serve several key biological functions pertinent to human health. These include:

The Generation of ATP
Co Q10 is critical in generating the synthesis of ATP (or adenosine triphosphate, the energy “currency” of all cells). This process takes place in the mitochondria and involves an intricate and complex cascade of enzymatic reactions called the “electron transfer chain”. Indeed, Co-Q10 is most notably found in the inner membrane of the mitochondrion.

Acts as a Redox agent
Co Q10 keeps other antioxidants (e.g. vitamins E and C) in their reduced active states. For example, as vitamins C and E perform their functions as antioxidants, they themselves become oxidized. Since these vitamins are active in their reduced forms, Co Q10 recharges them (reduces them) to their active states by accepting electrons.

Antioxidant activity
Biological oxidation is a ubiquitous event that occurs continually in the body, causing havoc and numerous pathological conditions. Oxidation results from the breakdown of oxygen molecules as they combine with other molecules in the body. Such oxidation can be the result of the body’s normal metabolism of the foods we eat, or it can occur in the body as a result of external forces such as exercise, radiation, pollution, alcohol or heavy metal intoxication, infections etc. The resulting free radicals are highly reactive molecules, which interfere with enzymatic reactions and cause disruption of cell membranes and even DNA. Co-Q10 has a strong ability to give up electrons quickly and thus acts as a powerful antioxidant against free radicals, and affords protection against LDL oxidation, which is a pivotal step in the cause of atherosclerosis. Co-Q10 also stabilizes cell membranes and platelets.

Research

The use of Co-Q10 as adjunctive therapy in the treatment of heart failure goes back decades. In fact, Co-Q10 has been approved as a drug in Japan for the treatment of congestive heart failure since 1974, with a number of other nations following suite. Placebo-controlled studies to date with Co-Q10 (including one study conducted in Italy which included 2,664 patients with congestive heart failure) have produced what scientists call ‘significantly positive results’. These results include diminished levels of fatigue, chest pain, dyspnea and palpitations. Treatment with Co-Q10 was even able to restore normal heart size and function in some patients – primarily those whose onset of congestive heart failure was relatively recent.

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There have also been many studies examining the effect of Co-Q10 as an addition to standard medical treatments, particularly those pertaining to hypertension and other manifestations of cardiovascular disease. When Co-Q10 was added as a concurrent treatment alongside the standard drug therapies for these conditions, the result was a significant reduction in the required use of the aforementioned drug therapies in order to alleviate the conditions in question.

Energy and Exercise
CoQ10′s antioxidant and membrane stabilizing abilities have been shown to protect skeletal muscle cells from injury. A recent study found that young men training in the intense Japanese sport Kendo had lower serum activity of creatine kinase and lower serum myoglobin concentrations when they were given CoQ10 supplements. These two markers are associated with skeletal muscle damage, indicating that CoQ10 reduces exercise-induced muscular injury.

Another recent study tested the effects of CoQ10 on exercise-induced fatigue. In this double-blind, randomized, placebo-controlled, three crossover design, 17 healthy subjects were given 300 mg CoQ10 for a week before performing a workload trial on a bicycle ergometer to induce fatigue. To test their physical performance, they performed non-workload trials at maximum velocity for 10 seconds at 30 minutes and 210 minutes of the fatigue-inducing trial. The study found that the decrease in physical performance due to physical fatigue was inhibited in the CoQ10 group compared to the placebo. Also, CoQ10 alleviated the sensation of fatigue compared to the placebo group.

Complications
None reported. Shown to be useful with Beta-blockers, psychotropic drugs including phenothiazines and tricyclic antidepressants. A 1994 Lancet study reported 3 cases where Co Q10 reduced the effect of coumadin. No other cases have been reported. It may be wise to monitor the prothrombin when supplementing with Co Q10.

Market Trends

Antioxidants are increasingly popular for their use in preventive health measures as well as for slowing the aging process. There are several options available on the market. Co-enzyme Q10 is one of the most proven and valued antioxidants available, and one of the most recognized by western medicine.

AOR Advantage

AOR’s Co-enzyme Q10 is a powerful antioxidant, protecting cells from the damaging actions of free radicals that are produced as waste products during energy metabolism. Not only does it have antioxidant activity itself, it also recharges other antioxidants to keep them active.



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