PHYTO-C contains antioxidants for the maintenance
of good health. It also contains IP6, inositol hexaphosphate, a widely
distributed plant bioactive which research suggests that IP6 supports
normal cell growth and development as well as natural cell defense. IP6
also exerts an indirect antioxidant effect through the chelation of free
transition metals and supports kidney function. Research supports
synergistic interactions with green tea catechins and with inositol.
Phyto C pairs IP6 with vitamin C, a powerful and effective antioxidant.
| NPN
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Product Code
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Size
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Per Capsule
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Vegetarian
|
| 80024623
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AOR04256
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90 Vegi-Caps
|
33.3 mg
|
100% Vegetarian
|
| Supplement Facts
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| Serving Size: 3 Capsules
|
|
|
|
|
| Vitamin C (L-ascorbic acid)
|
100 mg
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|
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| Non-medicinal ingredients: calcium phytate 1500mg per serving. Capsule; hypomellose, water. Ingredients
|
AOR™ guarantees that no ingredients not listed on
the label have been added to the product. Contains no wheat, gluten,
corn, nuts, dairy, eggs, fish, shellfish or any animal byproduct.
Suggested Use
Take one capsule three times a day on an empty stomach or as directed by a qualified health care practitioner.
Main Applications
As reported by literature:
• Inhibits cellular proliferation and de-differentiation.
• Free iron chelator.
• Naturally fortifies cellular defenses.
Pregnancy / Nursing
No studies, but believed safe.
Cautions
Consult a health care practioner prior to use if you are pregnant or nursing, have cancer, cardiovascular disease, or diabetes.
Chemically, Inositol Hexaphosphate (IP6) is a central inositol
ring structure surrounded by six phosphate groups. IP6 and its
metabolites are found in every mammalian cell. A University of Maryland
Medical School researcher, Dr. Shamsuddin, and his colleagues, have
found that this common, naturally occurring substance can shrink tumors,
stop their growth, and may even induce differentiation, transforming
cancer cells into normal, healthy ones. These remarkable properties were
recently reported to the American Association for Cancer Research in
1996.
IP6 is normally found in high concentration in many fibers,
and some authors have suggested that IP6 may be one of the protective
compounds that give fiber its anticancer benefits. For instance, in
Finland, a country that consumes both a high fat diet and plenty of
fiber, the risk of breast cancer in women is lower than in the US, where
a typical diet is high-fat, low-fiber. More interestingly, the Danes
consume double the total fiber of Finns, and yet the Finns have only
half the rate of colon cancer. One possible explanation for this paradox
is that the sources of fiber in the Finnish diet yields considerably
more IP6 than do those used by the Danes.
Shrinking Tumors
In a study of human liver
cancer cells transplanted into mice that were subsequently treated with
IP6, the researchers found that IP6 slowed or stopped the growth of
liver cancer cells and shrank existing tumors three to four fold. In one
human liver cell study, Shamsuddin's team treated human
hepato-carcinoma cells with varying doses of pure IP6. The result was
partial to complete inhibition of cell growth and proliferation. Treated
cells transplanted into mice produced no tumors over the 41 days of the
experiment, while 71% of control mice developed tumors. When these
control mice were treated with IP6 for 12 days, their tumors weighed 3-4
fold less than before IP6 treatment, suggesting that IP6 is useful as a
preventative and as a treatment.
Shamsuddin has tested IP6 on colon, lung, breast, prostate, leukemia,
fibrosarcomas, and muscle cell cancer in test tubes and in experimental
animals, including human cancers transplanted into animals. In all
types, whether IP6 is administered before, during, or after exposure to a
carcinogen or the development of tumors, treated animals have shown
fewer, smaller tumors with reduced growth rates.
Inducing Differentiation
Cancer cells are not
simply normal cells that grow too quickly. They also fail to
differentiate. Nearly every cell in the body contains the DNA for the
entire organism, but a healthy cell only turns on a small portion of
this DNA, so that a lung cell is different from a brain cell, a liver
cell, or a red blood cell. Cancer cells fail to undergo this process,
which gives them an ominous, primitive appearance and prevents them from
performing their normal function in the body. Histological studies have
shown that IP6-treated human cancer cells (including the colon cancer
cell line HT-29, rhabdomyosarcomas, HepG2 human liver cancer, and
erhythmoleukemias) show signs of differentiation, returning them to
normal appearance and function (phenotype). As Shamsuddin has remarked,
"IP6 does not kill cancer cells; it tames them and makes them behave
like normal cells."
Mechanisms of Action
There are several probable ways that IP6 exerts its effects:
(1) Antioxidant Protection through Chelation:
Antioxidants are believed to fight cancer because they prevent free
radical damage to DNA. Unbound iron (ferritin), though not a free
radical itself, can be the catalyst for the deadly Fenton Reaction, in
which iron reacts with the relatively harmless hydrogen peroxide (H2O2)
and forms the highly reactive hydroxyl radical (OH.). IP6 chelates free
iron, thereby preventing the hydroxyl radical production before it
starts.
(2) Immune Function: Animal experiments conducted by
Dr. Shamsuddin have clearly shown dramatic increases in the activity of
Natural Killer Cells (NK) in animals treated with IP6. This increase
corresponds neatly with decreased tumor incidence in treated animals, as
one would expect, since NK cells' main function in the body is to seek
out and destroy cancerous and virus-infected cells.
(3) Cellular Signaling: The inositol phosphates
(IPs) are involved in cellular signaling, regulating calcium balance
within the cell and thus the rate of cell division. Dr. Shamsuddin has
shown that IP6 administration both elevates the levels of several IPs
within the cell and slows cell division. This may in part explain IP6's
anti-cancer activity.
(4) Gene Expression: IP6 appears to be a competitive
inhibitor for the enzyme phosphatidylinositol-3 kinase (PI3K), which is
the enzyme that activates activator protein 1 (AP-1). AP-1 is a protein
transcription factor induced by asbestos and other cancer promoters,
which binds to, and activates, known cancer genes such as c-FOS and
c-JUN. IP6 has also been reported to up regulate expression of the
tumor-suppression gene p-53, an exciting development indeed.
Although IP6 is found in a number of legumes and grains, the
absorption from food sources is not always good, because the IP6 is
tightly bound to elements within the fiber. This explains why pure,
isolated IP6 has thus been shown to fight tumors more effectively than
an equal amount of IP6 in fiber. IP6 should be taken between meals in
order to ensure that it does not compete with such elements in food.
Experts advise that consuming 2g of IP6 per day in supplemental form
provides good "health insurance" to support natural cell defenses. The
addition of vitamin C to Phyto C helps to provide additional antioxidant
support for this beneficial nutrient.
PHYTO-C contains antioxidants for the maintenance of good health. It also contains IP6, inositol hexaphosphate, a widely distributed plant bioactive which research suggests that IP6 supports normal cell growth and development as well as natural cell defen
AOR Supplements & Vitamins
SKU Number: AOR04256
On Sale - AOR Supplements
UPC 0062491704256