AOR™ guarantees that no ingredients not listed on the label have been added to the product. Contains no corn, wheat, gluten, nuts, dairy, soy, eggs, fish, shellfish or any animal byproduct.

Suggested Use:
Take 1 capsule three times daily, or as directed by a qualified health care practitioner.

Main Applications:

*Gout
*Elevated uric acid levels

Source:

Natural botanical extracts

Cautions: Consult a health care practitioner for use beyond 6 weeks. Consume with at least one liter of water throughout the day.

Pregnancy/Nursing:
Do not use if pregnant or breastfeeding.

GOUT
Gout, also referred to as metabolic arthritis or acute inflammatory monoarthritis, is caused by an abnormal build-up of uric acid in the blood - uric acid being a metabolic by-product of purine metabolism. Purines are natural substances found in many foods, and particularly in high protein foods like organ meats and fish like mackerel and sardines. Excessive blood levels of uric acid then lead to acute inflammation of the joints.  'Classic Gout' which usually targets the joints of the big toe and other joints within the legs and feet and can affect people of all ages. However, another type of gout - called 'Atypical Gout' - can affect any joint in either the arms or legs and is observed predominantly in the elderly. Both types of gout are characterized by excruciating pain and swelling. In many typical cases of gout, patients are overweight, predisposed to Type II diabetes and hypertension, and are at a higher risk of cardiovascular disease. Gout is disproportionately found in societies whose diets include large amounts of protein, fat and alcohol. Since a fundamental facet of gout is the metabolism of protein, the areas of kidney, bladder and urinary tract health are primary targets for treatment.

TREATMENT OPTIONS
Mulberry
Mulberry has been used for centuries in Chinese medicine to help reduce the symptoms of gout. Recent research has shown that the key to mulberry’s anti-gout actions may be a unique phytochemical called Morin. Morin (or 3,5,7,2',4'- Pentahydroxyflavone) is a naturally-occurring flavone found in the twigs of White Mulberry. Animal studies have revealed that morin effectively inhibits the uptake of urate and to lower uric acid levels in rats. In fact, the precise mechanism of action for morin appears to be two-fold and effectively synergistic. Firstly, it acts on the kidneys to inhibit uric acid reabsorption and thus promote the excretion of uric acid from the body. Secondly, it inhibits the enzyme xanthine oxidase, which is responsible for breakdown of purines into uric acid. In-vitro studies have also demonstrated an anti-atherosclerosis potential on the part of morin.

Polyphenols: Grape Seed Extract and Resveratrol
Polyphenols can also play a role in the prevention of kidney stones and help support the urinary system. Resveratrol, an exceptionally potent compound of this class, has been shown in-vitro to be capable of directly inhibiting xanthine oxidase activity. Polyphenols found in grape seed extract, have been shown, in-vitro, to cause a reduction in xanthine oxidase (XO) and xanthine-induced intracellular reactive oxygen species (ROS) accumulation. Researchers at the University of Hong Kong have identified ROS as being an important contributing factor in gouty arthritis. In animal models of gout (chickens), grape seed extracts have been shown to be highly effective at reducing serum uric acid levels.

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