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AOR, GLA-240, 90 softgels - GLA-240 is gamma-linolenic acid (GLA), an "activated" fatty acid found in evening primrose oil and in more concentrated form in borage oil. Extensive scientific research shows that GLA supplementation favorably modulates the body's balance of eicosanoids.
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AOR, GLA-240, 90 softgels

AOR GLA 240 organic gamma linolenic acid - 90 softgels
GLA 240 organic gamma linolenic acid - 90 softgels, aor vitamins supplements
AOR, GLA-240, 90 softgels is manufactured by AOR Supplements

Last updated on 12/5/2016


  • Anti-inflammatory
  • Relieves pressure in joints and blood vessels
  • Relieves symptoms of premenstrual syndrome
  • Reduces symptoms of rheumatoid arthritis

GLA-240 is organic borage oil, a richer source of the omega-6 essential fatty acid gamma-linolenic acid (GLA), than evening primrose oil.

NPN Product Code Size Per Capsule Vegetarian
02172933 AOR04327 90 Softgels 240 mg
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving

Gamma linolenic acid (GLA) 240 mg

Non-medicinal Ingredients: d-alpha-tocopherol (5 IU). Softgel: gelatin (bovine), glycerin.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish.

Adult Dosage: Take 1 softgel daily with a fat-containing meal, or as directed by a qualified health consultant.

• Possible interactions with phenothiazines (increasing seizure risk).
• May cause headaches and/or nausea.
• May increase bleeding time.

Pregnancy/Nursing: Consult a qualified health care practitioner

Organic Borage Oil

Main Indications:

  • Inflammation, swelling and pain
  • Pressure in joints, blood vessels
  • Water retention
  • Allergic response
  • Nerve transmission
  • PMS
  • Vascular health
  • Eczema


Background Information

The first vegetable source of the omega-6 fatty acid gamma-linolenic acid (GLA) was discovered in the oil of evening primrose seeds (where GLA content is 9%). This oil became well known with the public, health professionals, and in health stores. Then GLA was also discovered in borage and black current in higher amounts, 24% and 17% respectively. A 1992 study published in the journal ‘Lipids’ showed that “there was no significant difference in tissue GLA levels within groups given equal amounts of dietary GLA either in borage oil or evening primrose oil”. In order to ingest 240 mg of GLA, only 1000 mg of 24% borage oil needs to be taken compared to 2660 mg of EPO. Because reduced consumption of oil is desirable as a rule, the higher GLA potency of borage oil makes it preferable to evening primrose oil.

Borage is a plant with star shaped, periwinkle-blue flowers. The plant produces a dark, rich oil that contains valuable therapeutic lipids. The seed pod usually contains about 25% oil content.

Read More

The body is capable of naturally producing GLA. In order to do this, it must have its starting material, linoleic acid (LA). This is an essential fatty acid that the body is unable to make and must be ingested as part of the everyday diet. Fortunately, most people get plenty of LA in their daily diet, since it is commonly found in almost all edible vegetable oils.

Once LA is ingested, it is acted upon by an enzyme called delta-6-desaturase (D6D) which biochemically converts LA to GLA. This is how the body gets its daily fix of GLA. Without the effective functioning of D6D, the body is unable to manufacture any GLA no matter how much LA is ingested. GLA is further converted via a sequence of biochemical steps into prostaglandin 1 (PGE1), a key molecule with numerous biological properties including:

• Anti-inflammatory
• Dermatology (e.g. eczema)
• Anti-allergy
• Nerve transmission
• Secretion from the mucus membrane
• Steroid production and hormone synthesis


In rheumatoid arthritis (RA), benefit from non-steroidal anti-inflammatory drugs (NSAIDs) is mediated through inhibition of the cyclo-oxygenase enzyme, thereby decreasing production of the 2 series prostaglandins (PG2). The Lipoxygenase enzyme is intact, however, allowing leukotriene (LT) production; e.g. LTB4 is an inflammatory mediator. Treatment with GLA-240 leads to the production of the prostaglandin 1 series PGE1, which has less inflammatory effects. In addition, LT production is inhibited.

Post-viral fatigue syndrome
63 adult patients were treated with GLA for 3 months in a double-blind, placebo-controlled study. All patients had been ill for 1-3 years of a viral infection and were suffering from myalgia, severe fatigue and a variety of psychiatric symptoms. The essential fatty acid composition of the red cell membrane phospholipid improved significantly.


414 patients with mastalgia were treated with Danazol, bromocriptine, or GLA. Danazol was the most effective, with GLA and bromocriptine having equivalent efficacy. However, many more adverse effects were noted with danazol and bromocriptine.

Diabetic neuropathy
A 1 year study observed 111 patients with mild diabetic neuropathy who were treated with 480mg of GLA per day and assessed for 16 parameters including tendon reflexes, muscle strength, hot and cold sensation etc. For all parameters, the changes were more favorable and statistically significant in the GLA group. The conclusion was that GLA had beneficial effects on the course of diabetic neuropathy.

Market Trends

Omega-6 fatty acids are supplemented in the diet as they are known to play an important role in maintaining healthy brain function, for promoting normal growth and development, and for improving the growth of hair and skin. They also play an important role in the functioning of the metabolism.

Evening Primrose Oil (EPO) is the most popular source of GLA omega-6 fatty acids. However, EPO tends to be very expensive, and many capsules per day are required to get the full therapeutic amount. Borage oil is an excellent alternative.

AOR Advantage

AOR offers an omega-6 fatty acid supplement of the highest quality. AOR’s GLA-240 is an extract from the seed pods of borage. Borage oil provides a more concentrated extract of GLA than does Evening Primrose oil, meaning that fewer capsules are required to get the same effect. It is a safe and well tolerated supplement that helps regulate inflammation and reduce the symptoms of a number of disorders.


Andreassi M, Forleo P, Di Lorio A, Masci S, Abate G, Amerio P. “Efficacy of gamma-linolenic acid in the treatment of patients with atopic dermatitis.” J Int Med Res 1997 Sep-Oct; 25(5): 266-74.

Fearon KC, Falconer JS, Ross JA, Carter DC, Hunter JO, Reynolds PD, Tuffnell Q. “An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate.” Anticancer Res 1996 Mar-Apr; 16(2): 867-74.

 Keen H, Payan J, Allawi J, Walker J, Jamal GA, Weir AI, Henderson LM, Bissessar EA, Watkins PJ, Sampson M, et al. “Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group.” Diabetes Care 1993 Jan; 16(1): 8-15.

Kruger MC, Coetzer H, de Winter R, Gericke G, van Papendorp DH. “Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis.” Aging (Milano) 1998 Oct; 10(5): 385.

Puolakka J, Makarainen L, Viinikka L, Ylikorkala O. “Biochemical and clinical effects of treating the premenstrual syndrome with prostaglandin synthesis precursors.” J Reprod Med 1985 Mar; 30(3): 149-53.

Zurier RB, Rossetti RG, Jacobson EW, DeMarco DM, Liu NY, Temming JE, White BM, Laposata M. “Gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial.” Arthritis Rheum 1996 Nov; 39(11): 1808-17.

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