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AOR, Ginkgo Biloba, 100mg, 90 caps - Ginkgo is widely used in Europe for the maintenance of healthy cognitive function, due to its support for cerebrovascular microcirculation and antioxidant properties.
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AOR, Ginkgo Biloba, 100mg, 90 caps

AOR Ginkgo Biloba 100mg - 90 vcaps
Ginkgo Biloba 100mg - 90 vcaps, aor vitamins supplements
AOR, Ginkgo Biloba, 100mg, 90 caps is manufactured by AOR Supplements

Last updated on 12/5/2016

Ginkgo Biloba

  • Enhances cognition
  • Supports blood flow in the brain
  • Antioxidant
  • Helps delay the onset of dementia

Ginkgo Biloba helps to enhance memory and cognitive function in adults, and helps to support peripheral circulation.

NPN Product Code Size Per Capsule Vegetarian
80011802 AOR04298 90 Vegi-Caps 120 mg Vegetarian
Supplement Facts
Serving Size: 1 Capsule   Amount Per Serving
 
Ginkgo biloba extract (50:1) 120 mg
Ginkgoflavanglycosides 24%
Terpene Lactones 6%
 
Non-medicinal ingredients: microcrystalline cellulose. Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, shellfish or any animal byproduct

Adult Dosage: Take 1 capsule daily with/without food, or as directed by a qualified health care practitioner. Consult a health care practitioner for use beyond 6 weeks.Main Applications

Cautions: Consult a health care practitioner prior to use if you are taking medications for diabetes, high blood pressure, or seizures. Do not use if you are taking health products that affect blood coagulation (e.g. blood thinners, clotting factor replacements, acetylsalicylic acid, ibuprofen, fish oils, vitamin E) as this may increase the risk of spontaneous bleeding.

Pregnancy/Nursing: Do not take if you are if you are pregnant or breastfeeding or are trying to become pregnant. Animal studies suggest that key phytonutrients in Ginkgo may interfere with embryonic development.

Source:
Ginkgo tree leaves harvested at the peak of terpene lactone content

Main Indications:

  • Age-related cognitive decline
  • Cerebral vascular support
  • Antioxidant
  • Cognitive enhancement
  • Cardiovascular disease
  • Tinnitus
  • Peripheral circulation

Research

Background Information

Ginkgo biloba is one of the most well-known and most-sold herbs around the world. Its use in traditional folk medicine goes back to “Chen Houng Pen T’sao” – a form of pharmacopoeia created in ancient China around the year 2800 BC. Ginkgo is the sole survivor of a tree species, dating back over 200 million years ago that has become legendary for its durability and its ability to extract nutrients from the soil.

Ginkgo is monographed in the modern Chinese Pharmacopoeia as well as in the United States and Germany. In fact, Ginkgo biloba extract has been proven in Germany (in accordance with the Commission E monographs) to reduce the symptoms of cerebral insufficiency. These symptoms include memory loss associated with conditions such as Alzheimer’s disease and vascular dementia, among others. Ginkgo is also used to cope with the symptoms of tinnitus, vertigo and of intermittent claudication (inadequate blood flow to the lower limbs). Studies also show that Ginkgo biloba enhances the integrity of the capillary walls and protects nerve cells of brain damage associated with a lack of oxygen.

Ginkgo biloba contains a variety of compounds, but the two main active ingredients, namely terpenoid lactones and flavonoids are responsible for the central effects of increased cerebral blood flow and protection against oxidants.

1. Terpenoid Lactones
Terpenoid substances impart a strong, bitter flavor. Ginkgo Biloba 50:1 contains a minimum of 6% terpene lactones, considered the highest percent available.

2. Flavonoids (Antioxidant Potential)
a. Ginkgoflavonglycosides (also called heterosides). Ginkgo flavonoids are up to 10 times more potent than citrus bioflavonoids. Ginkgo Biloba 50:1 is standardized for 24% flavonoids. Some of the flavonoids found in Ginkgo biloba include quercetin, kaempferol and isorhamnetin.
b. Proanthocyanidins, which are ionized (negatively charged) flavonoids, are also found in pine bark, grape skin and grape seeds.
c. Other flavonoid groups found in minor quantities are coumarin esters and catechins.
d. The most potent and important compounds in Ginkgo biloba are the ginkgolides A and B. Ginkgo Biloba 50:1 is rich in ginkgolides, containing a minimum of 0.8% — the highest range available.

Studies by Casato, Doly, Fink, and others strongly suggest that ginkgolide B is the most important component of Ginkgo biloba. Ginkgolide B has been isolated and studied as compound BN 52021 and shown to have biological effects. In fact, editor Pierre Braquet, Ph.D’s review text on the effects of ginkgo is entitled “Ginkgolides and ginkgo flavonoids”. According to Braquet, the world’s leading authority on Ginkgo biloba, the extracts are 90% absorbed.

Cognitive Benefits
Ginkgo biloba enhances cerebral microcirculation in the brain, keeping needed energy and oxygen flowing to the brain. Many controlled trials have demonstrated the ability of Ginkgo to support cognitive function.

Research

Good for Both Young and Old
• A recent randomized, double-blind, placebo-controlled trial found that 4 weeks of treatment with Ginkgo biloba extract in younger patients led to significantly superior measures of anxiety disorder or adjustment disorder with anxious mood compared to the placebo group.
• A meta-analysis of nine studies concluded that Ginkgo biloba extracts are beneficial in dementia.
• A randomized, double-blind, placebo-controlled, parallel-group, multicenter study tested the effects of Ginkgo biloba extracts for 52 weeks in Alzheimer patients with mild to severe dementia. In 202 patients, the extract appeared to be capable of stabilizing and improving the cognitive performance and the social functioning of demented patients. It has also been shown to delay the onset of Alzheimer’s disease.
• A randomized, placebo-controlled, double-blind study of 60 Alzheimer’s patients compared Ginkgo biloba extract to the drug donepezil. After a 24 week supplementation period, Ginkgo biloba was found to be comparable to donepezil in its improvements compared to the placebo group, as assessed by the Clinical Global Impression score.

Ginkgo biloba is also useful for those whose mental faculties have not yet begun to decline.

• A randomized, double-blind, placebo-controlled, parallel-group study gave Ginkgo biloba extracts to 60 healthy volunteers between 50 and 65 years of age. After 4 weeks, self-estimated mental health and quality of life were significantly better in the Ginkgo group compared to placebo.
• A placebo-controlled, double-blind, crossover study found that acute administration of Ginkgo biloba (120-360 mg) produced a sustained improvement in attention in healthy young adults compared to placebo.

Cancer fighting potential
Ginkgo biloba is beneficial in fighting cancer. In vitro studies have found that it is effective against various forms of human cancer cells, including ovarian cancer, breast cancer and hepatocellular carcinoma. A clinical trial found that Ginkgo biloba decreased the risk of ovarian cancer. These effects are partly due to the anti-proliferative effects of Ginkgo extracts, along with quercetin and ginkgolide A and B. The latter appear to be able to block the cell cycle, thereby preventing cancer cells from continuing to divide.

Ginkgo biloba has overall been found to be safe and well tolerated, although it does have several potential drug interactions to be aware of.

Market Trends

Ginkgo biloba is mostly known for its memory-enhancing effects. The most potent and important compounds in Ginkgo biloba are the ginkgolides A and B.

AOR Advantage

AOR’s Ginkgo Biloba 50:1 begins with its plantation-grown leaves. Japan Greenwave carefully cultivates their own leaves on plantations using agricultural technology to produce leaves richer and more potent in ginkgolide B, yielding a minimum of 0.8% – the highest range available. AOR’s Ginkgo Biloba is a well-standardized extract, with effective quantities of active ingredients to maintain the optimal health of your mind.

Only the Best Extract
Ginkgo Biloba 50:1 begins with its plantation-grown leaves. Japan Greenwave carefully cultivates their own leaves on plantations using agricultural technology to produce leaves richer and more potent in ginkgolide B. No extraction technology can compensate for inferior plant material. Much of the original European research on Ginkgo biloba extract used Japan Greenwave leaves for their extractions.

Ginkgo Biloba 50:1 extract:

  • Is rich in Ginkgolides A and B
  • Is standardized to 24% Ginkgoflavonglycosides
  • Contains 6% Terpene Lactones, including:
  • Ginkgolide A – 1.2% (minimum)
  • Ginkgolide B – 0.8% (minimum)
  • Ginkgolide C – 1.0% (minimum)
  • Bilobalide – 2.8% (minimum)
  • Uses plantation-cultivated leaves from Japan Greenwave
  • Employs scientifically controlled standardized extraction, from leaf to extract, by Japan Greenwave

References

Cieza, A., Maier, P., and Poppel, E. Effects of Ginkgo biloba on mental functioning in healthy volunteers. Arch Med Res. 2003;34(5):373-381.

Ernst E, Pittler MH. Ginkgo biloba for dementia: a systematic review of double-blind, placebo-controlled trials. Clin Drug Invest . 1999;17:301-308.



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