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AOR, Curcumin-95, 400mg, 90 caps - Curcumin95 is a standardized extract of curcuminoid complex, has antioxidant effects, modulation of the production of inflammatory signal molecules (prostanoids and leukotrienes), key botanical extract in traditional Ayurvedic medicine.
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AOR, Curcumin-95, 400mg, 90 caps

AOR Curcumin 95 - 90 vcaps
Curcumin 95 - 90 vcaps, aor vitamins supplements
AOR, Curcumin-95, 400mg, 90 caps is manufactured by AOR Supplements

Last updated on 12/5/2016
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Curcumin-95

  •  Anti-inflammatory
  •  Lowers cholesterol
  •  Anti-tumor
  •  Fights bacteria

Curcumin is used in Herbal medicine to help relieve joint inflammation and provides antioxidants for the maintenance of good health.

NPN Product Code Size Per Capsule Vegetarian
80020741 AOR04004 90 Vegi-Caps 400 mg Vegetarian
Supplement Facts
Serving Size: 1 Capsule Amount Per Capsule

Curcumin

 400 mg

 Non-medicinal ingredients: Capsule: hypromellose.
Note: Herbal extracts will naturally vary in color from one batch to another.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, soy, eggs, dairy, fish, shellfish or any animal byproducts.

Adult Dosage: Take 3 capsules per day, or as directed by a qualified health care practitioner.

Cautions: Consult a health care practitioner prior to use if you are taking antiplatelet medication or blood thinners, have gallstones or a bile duct obstruction, have stomach ulcers or excess stomach acid. Consult a health care practitioner if symptoms persist or worsen.

Pregnancy/Nursing: Consult a health care practitioner prior to use

Source:
Turmeric (Curcuma longa)

Main Indications:

  • Anti-oxidant
  • Anti-inflammatory
  • Gastro-intestinal effects
  • Cardiovascular effects
  • Lipid metabolism
  • Anti-bacterial/Anti-fungal
  • Anti-viral
  • Anti-tumor activity

Research

Background Information

Curcuma longa is a perennial herb that belongs to the ginger family. The rhizome is extensively used for imparting color and flavor to food including curries. As a powder, called turmeric, it is also used for medicinal and religious ceremonies. Curcumin is an extract of the herb turmeric (Curcuma longa Linn) which has wide-ranging health benefits. It is well known to have antioxidant effects, preventing cellular damage, and it reduces the production of inflammatory signals. It is also able to block the growth of abnormal cells, stopping cancer before it begins.

A Multi-tasking Supplement
Curcumin protects the liver from several toxins and regulates lipid metabolism to decrease cholesterol levels. It protects the gastric mucosa against irritants. It can fight off many unwanted invaders such as the bacteria Staphylococcus aureus and various fungal infections, and has even been shown to be a useful ally against HIV. Curcumin is able to protect the body from damage in a number of ways. More recently it has been discovered that curcumin is able to reduce the formation of dangerous amyloid beta plaques in the brain that are associated with Alzheimer’s disease.

Chemistry of Curcumin
Curcuma longa rhizomes yield about 8% essential oils and 10% fatty oil. Three major constituents have been identified:
(1.) Curcumin (diferuloyl methane)
(2.) Curcumin methane
(3.) Di-hydroxy cinnamoyl methane

The volatile oils contain cineol, camphor and linalool and are probably responsible for the antispasmodic activity. Borneol is present in the essential oil fraction and is largely responsible for the digestion-improving properties of curcumin.

Pharmacological Properties of Curcuma longa
The benefits of Curcuma longa have been extensively researched, especially by Indian scientists.

1. Antioxidant
Numerous studies have shown that the various constituents of Curcuma longa possess potent antioxidant properties. The ability of curcuminoids to reduce hydroxyl and peroxyl free radicals is well documented. Sharma reported curcumin to be an effective agent against lipid peroxidation.

Read More

2. Anti-inflammatory
The Central Drug Research Institute in India found curcumin to be the major constituent responsible for the anti-inflammatory activity. The classical model for studying acute effects of anti-inflammatory agents is to test their inhibitory action on the development of rat paw edema – the exudative phase of inflammation – induced, for instance, by the local injection of carrageenan. Thus inflammation is thought to be in part due to the action of prostaglandin derivative from arachidonic acid metabolism. A detailed evaluation of curcumin as a potential non-steroidal anti-inflammatory agent by Srimal and Dhawan found curcumin to be highly effective after oral administration. Curcumin was effective in other models of inflammation including granuloma, pouch, cotton pellet, formalin-induced, and Freund’s adjuvant.

Many mechanisms of action have been attributed to curcumin. Some researchers found curcumin to be less effective in adrenalectomized rats, suggesting a participation of corticoidal steroids, while others did not observe any effect of curcumin salts on steroid release from the adrenal cortex. Recently, another, more specific in-vitro method has been developed which allows the study of the inhibitory mechanism of potential drugs. By using rat peritoneal neutrophilis, curcumin was tested for the direct effect on the 5-lipooxygenase activities. Another study found that curcumin was able to inhibit the production of pro-inflammatory mediators in microglial cells that had been stimulated to mount an inflammatory response. Microglial cells are activated after brain injuries and produce proinflammatory mediators and neurotoxic compounds. Curcumin decreased the production of these compounds, apparently by blocking NF-kB, a protein signal in the pathway that leads to their production. The overexpression of pro-inflammatory cytokines contributes to diseases such as Alzheimer’s, cerebral ischemia and many degenerative and inflammatory conditions. The ability of curcumin to decrease inflammation presents an approach to slow the progression of these diseases.

3. Gastro-intestinal effects
Curcumin increases mucin content, thereby protecting the gastric mucosa against irritants. Controversial data exist regarding an anti-ulcerogenic activity of curcumin. Some researchers found a protective effect of curcumin against histamine-induced gastric ulceration, while others reported an ulcerogenic effect of curcumin.

Curcumin also possesses anti-spasmodic properties. Curcumin showed liver protective effects against carbon tetrachloride, D-Galactosamine and peroxide induced cytotoxicity. Curcumin increased bile acid production in dogs and rats.

4. Cardiovascular effects
A sharp and transient hypotensive effect of curcumin was reported in dogs. Curcumin also inhibited collagen and adrenaline-induced aggregation of platelets but did not affect prostacyclin (PGI2) synthesis.

5. Lipid metabolism
Rao and co-workers reported that rats fed with curcumin and cholesterol in their diet had only half to one-third of the serum and liver cholesterol levels compared to the controlled groups receiving cholesterol alone.

6. Anti-bacterial/Anti-fungal
Curcumin inhibited growth of most organisms including: Staph aureus, Streptococci, Lactobacilli, Corynebacterium, Baccilus aureus, and Micrococcus pyogenes. The crude ether and chloroform extracts of Curcuma longa showed fungistatic activity against several dermatophytes as well as anti-amoebic activity against Entamoeba histolytica.

7. Anti-viral
A 1993 study showed curcumin as an effective ally in the treatment against HIV. Curcumin was effective in inhibiting the replication of HIV in both acutely infected and chronically infected cells.

8. Anti-tumor activity
The anti-tumor activity of various extracts of Curcuma longa has been remarked by several researchers. Topical application of curcumin inhibited the number of TPA-induced tumors by as much as 98%!! Curcumin was found to be a selective and non-competitive inhibitor of phosphorylase kinase.

Market Trends

Turmeric products have a longstanding reputation for being beneficial in the treatment and prevention of a variety of ailments. It is a substance that is considered very safe to use and that offers multiple health benefits. However, curcumin is the active ingredient in turmeric responsible for these effects, and it is the compound with which most of the clinical studies have been conducted, not turmeric.

AOR Advantage

AOR offers a standardized and potent curcumin extract, not a weak turmeric extract, that provides antioxidant, anticancer, anti-inflammatory, cholesterol lowering, anti-tumor and antimicrobial benefits.



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