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AOR, Glucosamine & Chondroitin, 675mg, 120 caps - Glucosamine and Chondroitin sulphate are components of the cartilage in joint tissue, and are used to support joint structure by aiding in the formation of connective tissue and protecting against the deterioration of cartilage from chronic joint diseases
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AOR, Glucosamine & Chondroitin, 675mg, 120 caps

AOR Glucosamine & Chondroitin Sulphate - 90 caps
Glucosamine & Chondroitin Sulphate - 90 caps, aor vitamins supplements
AOR, Glucosamine & Chondroitin, 675mg, 120 caps is manufactured by AOR Supplements

Last updated on 12/5/2016

Glucosamine & Chondroitin

  • Supports joint structure
  • Prevents cartilage deterioration
  • Relieves joint pain from arthritis
  • Cushions joint tissues

Glucosamine sulfate and chondroitin sulfate are components of the cartilage in joint tissue, supporting joint structure by aiding in the formation of connective tissue and protecting against the deterioration of cartilage from chronic joint diseases, while helping to relieve joint pain associated with osteoarthritis.

NPN Product Code Size Per Capsule Vegetarian
80042966 AOR04308 120 Capsules 675 mg
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving

Glucosamine Sulfate KCL 375 mg
Chondroitin Sulfate sodium 300 mg

Non-medicinal ingredients: microcrystalline cellulose. Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish or shellfish.

Adult Dosage: Take 3-4 capsules per day with food, or as directed by a qualified health care practitioner. Allow a minimum of one month to see beneficial effects.

Cautions: Consult a health care practitioner prior to use if symptoms worsen with ongoing supplementation.

Pregnancy/Nursing: Consult a health care practitioner prior to use

Source:
Chondroitin sulfate - bovine trachea;
Glucosamine sulfate - vegetarian, from biofermentation

Main Indications:

  •  Osteoarthritis
  •  Sports injuries
  •  Cartilage regeneration

Research

Background Information

Chondroitin Sulfate/Glucosamine Sulfate

Chemistry
Glucosamine is two hexosamine sugars common in animal cells. The synthesis of glucosamine begins with the enzyme glucosamine sythetase facilitating the transfer of amide group from glutamine to fructose-6 phosphate. The enzyme simultaneously isomerizes this compound to form glucosamine-6-phosphate (G-6-P). This molecule is the precursor to all hexosamine and hexosamine derivatives including: N-acetyl glucosamine, N-acetyl galactosamine and N-acetyl neuraminic acid. Chondroitin sulphate (CS) is a heterogenous group of glycosaminoglycan that is further classified into chondroitin-4-sulphate (CS4) or chondroitin-6-sulphate (CS6). CS functions as a component of proteoglycans. The low molecular weight and its high solubility enable GS to be readily absorbed in the blood stream (over 90% of an oral dose). Evidence indicates absorption of GS to be via active transport. GS is rapidly incorporated into articular cartilage. CS on the other hand is absorbed poorly due to the wide range of chain lengths and molecular weights. Estimations range between 0.8% and 8.5% absorption of CS intact. It would seem unlikely that the physiological benefits of CS are due to the intact molecule rather than to the increased availability of monosaccharide building blocks (glucuronic acid and N-acetyl glucosamine) created by the hydrolysis of CS during digestion and absorption.

Research

Clinical Applications of Glucosamine and Chondroitin Sulphate
Glucosamine is a very well studied joint-support supplement.

• A review of a number of clinical studies showed that over 90% of patients reported improvement of symptoms after taking 1 500mg GS daily for 50 days. Arthritis of the shoulder or elbow responded the best, while polyarticular arthritis of the hip had the poorer rate- 43% reported feeling better compared to 49% who reported no improvement. CS in various formulations produced similar effects. Co-administration of CS resulted in 72% reduction in the effective dose of NSAIDs required to relieve pain.

• Another study comparing Voltaren (a prescriptive NSAID) with CS showed that Voltaren produced a prompt reduction in clinical symptoms; however the symptoms reappeared quickly after the discontinuation of treatment. Patients treated with CS had a slower response to treatment, although the favorable response remained up to three months after discontinuation of treatment.
• Forty-two patients (aged 35-78) with symptomatic osteoarthritis of the knee received 800mg daily dose of CS or placebo for 1 year. After 3 months, joint pain was significantly reduced. The difference in pain reduction became even more marked after 12 months (63% vs 26%; p<0.01).

An Effective Combination
Studies using the combination of chondroitin sulfate and glucosamine have demonstrated its effectiveness.

• In patients with capsulitis, disk displacement, disk dislocation or painful osteoarthritis of the temporomandibular joint, 1500 mg of glucosamine and 1200 mg of CS for 12 weeks reduced pain and joint tenderness, as well as the daily amount of over-the-counter medications required.
• In another study, glucosamine (1500mg/day) and CS (1200 mg/day) reduced pain in patients with knee osteoarthritis who had been suffering from moderate-to-severe knee pain.

Market Trends

There are a number of medications on the market that are prescribed to reduce joint pain. Unfortunately some non-steroidal anti-inflammatory medications can carry significant and serious side effects and may not have a long lasting effect.

AOR Advantage

Glucosamine and chondroitin sulphate are two well researched nutrients for joint support. AOR’s combination formula provides natural and effective relief for joint pain.



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