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AOR, UTI Cleanse Now with Cranberry, 120 tabs - AOR UTI Cleanse Now with Cranberry helps prevent recurrent urinary tract infections (UTIs) and is a source of antioxidants for the maintenance of good health..
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AOR, UTI Cleanse Now with Cranberry, 120 tabs


AOR, UTI Cleanse Now with Cranberry, 120 tabs is manufactured by AOR Supplements

Last updated on 12/5/2016

AOR UTI Cleanse now with Cranberry Tablets

  •  Helps fight off acute UTIs
  •  Helps prevent UTI recurrence
  •  Prevents bacteria from binding to the urinary tract
  •  Safe and effective relief without the side-effects of antibiotics

AOR UTI Cleanse now with Cranberry is used in herbal medicine to help prevent urinary tract infections (UTIs) and is a source of antioxidants for the maintenance of good health.

NPN Product Code Size Per Capsule Vegetarian
80030062 AOR04282 120 Tablets 100 mg Vegetarian
80030062 AOR04286 60 Tablets 100 mg Vegetarian
Supplement Facts
Serving Size: 1 Tablet
 

Dried Cranberry juice (Vaccinium macrocarpon Aiton) 100 mg
Non-medicinal ingredients: D-Mannose (1000mg), magnesium hydroxide, silicon dioxide, microcrystalline cellulose, sodium stearyl fumarate, carboxymethylcellulose sodium, and tricalcium phosphate.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, dairy, soy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage: Take 1-2 tablets 4-5 times daily without food or as directed by a qualified health care practitioner. Use for a minimum of 4 weeks to see beneficial effects.

Cautions: Consult a health care practitioner prior to use if you are taking blood thinners or have a history of kidney stones. Consult a health care practitioner if symptoms persist or worsen.

Pregnancy/Nursing: Consult a health care practitioner

Source:
Cranberry; D-Mannose - Norwegian birch tree bark

Main Indications:

  • Urinary tract infections

Research

A Superior Combination
UTI Cleanse now with Cranberry combines two ingredients that are well known and highly effective for the natural prevention and treatment of UTI’s, namely D-Mannose and Cranberry Extract. This superior and convenient combination provides a one-two punch for individuals battling recurrent urinary tract infections.

What Causes Urinary Tract Infections?
Although urinary tract infections (UTIs) can involve a variety of different bacteria species (including Staphylococcus saprophyticus and some Enterococci species), nearly all infections of the lower urinary tract and bladder are caused by a few strains of E. coli bacteria called uropathogenic Escherichia coli (UPEC). Various harmless strains of E. coli are normally present in the body – but they don’t belong in the urinary tract. Infection can occur when they manage to migrate from the gut to the bladder or urethra.

If UPEC manage to migrate from the gut into the bladder or the urethra, the body has ways of fighting them off – including the obvious method of simply flushing them out with the urine. But these bacteria have evolved ways of anchoring themselves to the cells of the urinary tract. The invading UPEC take advantage of D-mannose receptors naturally found on the cells of the mucosal lining of the urinary tract. UPEC use what are called type I pili to first hook on to these receptors, and then to invade the cell.

The Role of D-Mannose in the Prevention and Treatment of UTI’s
The chemical attraction between UPEC pili and D-Mannose is their strength – but it also provides a point of vulnerability. If you can interfere with the binding of their pili to the D-Mannose residues in the receptors of your urinary tract cells, then you can also prevent UPEC from getting a foothold for adherence and infection. One way to do this, long known to work in a test tube, is by using D-Mannose itself. When isolated urinary tract cells are bathed in D-Mannose, it acts as molecular “chaff.” The bacterial adhesins bind to the D-Mannose in their environment instead of to the D-Mannose residues on the cells, allowing them to be flushed out in the urine along with the D-mannose.

Cranberry Extract for an Enhanced Effect
Cranberries have been used in the treatment of UTIs for many years and are now regarded as a non-pharmaceutical approach for the treatment and prevention of simple UTI infections. Like D-Mannose, cranberries are effective in the treatment of the majority of UTI caused by by E.coli.

Cranberries and cranberry extracts contain certain tannins called proanthocyanidins that have been shown to reduce bacterial adherence to the urinary tract wall by altering the adhesion apparatus of the bacteria in as little as 3 hours after consumption. It is particularly the A-type linkages of the proanthocyanidins found in cranberries that make them effective, since praoanthocyanidins with B-type linkages are found to be less effective or ineffective. Cranberries also contain some D-mannose.

Note
Again, not all UTIs are caused by UPEC. So if you try a course of D-Mannose and infection persists, it is likely not caused by these E. coli bacteria but by some other pathogen. In that case, don’t just keep going on with the supplement in hopes that it will eventually “kick in:” discontinue use of D-Mannose and consult a physician for treatment appropriate to your case. But for the great majority of urinary tract infections, D-Mannose offers a safe, natural option with a simple, ingenious rationale, no known side-effects, and a great reported success rate.

D-Mannose
It was discovered in the late 1980s that a small amount of D-Mannose is normally present in the urine, apparently acting as a defensive mechanism against pathogenic bacteria. When D-Mannose is taken as a supplement, much more of the carbohydrate passes through the urinary tract, strengthening this natural defense.

A decade after this discovery, Dr. Jonathan V. Wright of the Tahoma Clinic pioneered the use of D-Mannose supplements to fight off UTIs. For some years, he has been reporting the successful results that his patients have experienced in using D-Mannose to rid themselves of infection. Even patients who had remained infected after having been subjected to a wide range of potent, side-effect-inducing antibiotics have successfully rid themselves of chronic or acute infections using D-Mannose. Other nutritionally oriented physicians and health practitioners have since adopted Dr. Wright’s protocols, and the feedback is uniformly excellent from UTI sufferers and their caregivers alike.

Recently, there has been greater interest by the pharmaceutical world in the effectiveness of a D-mannose derivative called α-D-mannoside which has begun to show good clinical therapeutic potential.

Cranberry
A Harvard study has demonstrated that regular use of cranberry juice reduced bacterial growth in the urinary tract. Studies have demonstrated that infections can be reduced by over 50% in elderly women drinking 300 ml of cranberry juice per day. Studies have documented that drinking eight glasses of cranberry juice twice a day can eradicate most UTIs. If consumption is maintained, infection is unlikely to recur.

Market Trends

Antibiotics are often prescribed to deal with UTIs. This is somewhat ironic because antibiotics kill friendly flora which help prevent bacteria from migrating into the urinary tract in the first place and are often a cause of UTIs.

Cranberry juice and supplements are the most well-known natural treatments for recurring urinary tract infections. Unfortunately, loading up on cranberry can be acidic, and some people develop intolerances to large amounts of cranberry with prolonged use.

AOR Advantage

Prevent recurrent UTIs naturally without the negative effects fo antibiotics. AOR’s UTI Cleanse now with Cranberry provides 1 gram per tablet of natural D-mannose extracted from Norwegian birch bark. It also contains the equivalent of less than a quarter of a teaspoon of cranberry juice per tablet so that those with intolerances to cranberry need not be concerned with such a small quantity. This product is also available as a powder in two sizes for your convenience.

References

Avorn J, Monane M, Gurwitz JH, Glynn RJ, Choodnovskiy I, Lipsitz LA. Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA 1994 Mar 9; 271(10): 751-4.

Head KA. Natural approaches to prevention and treatment of infections of the lower urinary tract. Altern Med Rev. 2008 Sep;13(3):227-44.

Howell AB, Botto H, Combescure C, Blanc-Potard AB, Gausa L, Matsumoto T, Tenke P, Sotto A, Lavigne JP. Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infect Dis. 2010 Apr 14;10:94.

Howell AB. Cranberry proanthocyanidins and the maintenance of urinary tract health. Crit Rev Food Sci Nutr 2002; 42(3 Suppl): 273-8.

Martinez JJ, Mulvey MA, Schilling JD, Pinkner JS, Hultgren SJ. Type 1 pilus-mediated bacterial invasion of bladder epithelial cells. EMBO J. 2000 Jun 15; 19(12): 2803-12.

Klein T, Abgottspon D, Wittwer M, Rabbani S, Herold J, Jiang X, Kleeb S, Lüthi C, Scharenberg M, Bezençon J, Gubler E, Pang L, Smiesko M, Cutting B, Schwardt O, Ernst B. FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation. J Med Chem. 2010 Dec 23;53(24):8627-41.

Sauer FG, Mulvey MA, Schilling JD, Martinez JJ, Hultgren SJ. Bacterial pili: molecular mechanisms of pathogenesis.Curr Opin Microbiol. 2000 Feb; 3(1): 65-72.

Stothers L. A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. Can J Urol 2002 Jun; 9(3): 1558-62.

Toyota S, Fukushi Y, Katoh S, Orikasa S, Suzuki Y. Anti-bacterial defense mechanism of the urinary bladder. Role of mannose in urine. Nippon Hinyokika Gakkai Zasshi. 1989 Dec; 80(12): 1816-23.

Wright JV. D-Mannose for bladder and kidney infections. Townsend Letter for Doctors and Patients. 1999 Jul; 192:96-98.


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