| Supplement Facts
|
| Serving Size: 1 Softgel
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|
Amount Per Serving
|
|
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| Coenzyme Q10 (ubiquinone-10)
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100mg
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|
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| Non-medicinal ingredients: Rice Bran Oil, alpha-tocopherol. Softgel: gelatin, glycerin, water, carob, hypromellose.
|
AOR guarantees that no ingredients not listed
on the label have been added to AOR CoQ10.
AOR CoQ10 Plus contains no wheat, gluten,
corn, nuts, dairy, eggs, fish, or shellfish.
Suggested Use
Take one to three capsules daily with food, or as directed by a qualified health care practitioner.
Main Applications
* Heart conditions
* Periodontal disease
* Immune disorders
* Cancer
* Blood sugar control
Source
Fermentation of sugar beets.
Pregnancy / Nursing
No studies, best to avoid.
Cautions
AOR CoQ10 may decrease the effectiveness of
warfarin; consult a health practitioner prior to taking this supplement
if you are on warfarin.
Coenzyme Q10 (AOR CoQ10 Plus) is a Vitamin-like substance that is found
in virtually all cells of the human body, thus earning CoQ10 its other
name, ubiquinone. Unlike vitamins, which by definition are not
synthesized within the body, CoQ10 is synthesized in nearly every
tissue of the body. It is also, in fact, not a vitamin at all but rather
a co-enzyme - an organic molecule that activates a larger protein
catalyst (an enzyme) that in turn facilitates a biological reaction
without extinguishing itself within that reaction.
Coenzyme Q10 has a quinone-like group (hence the Q) with 10
isoprenoid units as the side-chain (hence the 10). Quinones are
molecules that serve as electron receptors in essential biological
functions such as photosynthesis and respiration. CoQ10 quinone ring
is synthesized from the amino acid tyrosine whilst the isoprenoid side
chains are formed from acetyl CoA (of which pantethine is also a
precursor).
"AOR CoQ10 Plus" is very similar in structure to Vitamin K and Vitamin
E, although its role is quite different.
CoQ10 is a fat-soluble, crystalline compound with a Molecular
weight of 338.44 Daltons. CoQ10 functions as a co-enzyme in the
energy-producing metabolic pathways of every cell of the body with a
powerful antioxidant activity.
Biological functions
The fact that Coenzyme Q10 is able
to accept electrons in such a ubiquitous manner means that that it can
serve several key biological functions pertinent to human health. These
include:
The Generation of ATP
Co Q10 is critical in
generating the synthesis of ATP (or adenosine triphosphate, the energy
"currency" of all cells). This process takes place in the mitochondria
and involves an intricate and complex cascade of enzymatic reactions
called the "electron transfer chain". AOR CoQ10 Plus is most notably
found in the inner membrane of the mitochondrion.
Acts as a Redox agent
AOR CoQ10 Plus keeps other
antioxidants (e.g. vitamins E and C) in their reduced active states. For
example, as vitamins C and E perform their functions as antioxidants,
they themselves become oxidized. Since these vitamins are active in
their reduced forms, CoQ10 recharges them (reduces them) to their
active states by accepting electrons.
Antioxidant activity
Biological oxidation is a
ubiquitous event that occurs continually in the body, causing havoc and
numerous pathological conditions. Oxidation results from the breakdown
of oxygen molecules as they combine with other molecules in the body.
Such oxidation can be the result of the body's normal metabolism of the
foods we eat, or it can occur in the body as a result of external forces
such as exercise, radiation, pollution, alcohol or heavy metal
intoxication, infections etc. The resulting free radicals are highly
reactive molecules, which interfere with enzymatic reactions and cause
disruption of cell membranes and even DNA. CoQ10 has a strong ability
to give up electrons quickly and thus acts as a powerful antioxidant
against free radicals, and affords protection against LDL oxidation,
which is a pivotal step in the cause of atherosclerosis. AOR CoQ10 Plus also
stabilizes cell membranes and platelets.
The use of CoQ10 as adjunctive therapy in the treatment of heart
failure goes back decades. In fact, CoQ10 has been approved as a drug
in Japan for the treatment of congestive heart failure since 1974, with a
number of other nations following suite. Placebo-controlled studies to
date with CoQ10 (including one study conducted in Italy which included
2,664 patients with congestive heart failure) have produced what
scientists call ‘significantly positive results'. These results include
diminished levels of fatigue, chest pain, dyspnea and palpitations.
Treatment with CoQ10 was even able to restore normal heart size and
function in some patients - primarily those whose onset of congestive
heart failure was relatively recent.
There have also been many studies examining the effect of Coenzyme Q10 as
an addition to standard medical treatments, particularly those
pertaining to hypertension and other manifestations of cardiovascular
disease. When CoQ10 was added as a concurrent treatment alongside the
standard drug therapies for these conditions, the result was a
significant reduction in the required use of the aforementioned drug
therapies in order to alleviate the conditions in question.
Energy and Exercise
CoQ10's antioxidant and
membrane stabilizing abilities have been shown to protect skeletal
muscle cells from injury. A recent study found that young men training
in the intense Japanese sport Kendo had lower serum activity of creatine
kinase and lower serum myoglobin concentrations when they were given
CoQ10 supplements. These two markers are associated with skeletal muscle
damage, indicating that CoQ10 reduces exercise-induced muscular injury.
Another recent study tested the effects of CoQ10 on exercise-induced
fatigue. In this double-blind, randomized, placebo-controlled, three
crossover design, 17 healthy subjects were given 300 mg CoQ10 for a week
before performing a workload trial on a bicycle ergomerter to induce
fatigue. To test their physical performance, they performed non-workload
trials at maximum velocity for 10 seconds at 30 minutes and 210 minutes
of the fatigue-inducing trial. The study found that the decrease in
physical performance due to physical fatigue was inhibited in the CoQ10
group compared to the placebo. Also, CoQ10 alleviated the sensation of
fatigue compared to the placebo group.
Ensuring Absorption
A critical point to remember
is that CoQ10 is fat-soluble, and that absorption of CoQ10 has always
been a challenge. In fact, well over 60% of orally consumed Co-Q10 is
excreted in bowel movements and its absorption is not only variable but
also dependent on food intake, particularly the lipids present in the
food. Absorption is lower when CoQ10 is consumed on an empty stomach
and higher when taken with food that is comprised of high lipid content.
In order to overcome this potentially serious impediment to absorption,
AOR has introduced AOR CoQ 10 Plus. AOR CoQ 10 Plus provides a potent 100mg of Coenzyme Q10 (ubiquinone) in a softgel
comprised of a superior lipid-based delivery system to ensure maximum
absorption.
Coenzyme Q10 Complications
None reported. Shown to be useful
with Beta-blockers, psychotropic drugs including phenothiazines and
tricyclic antidepressants. A 1994 Lancet study reported 3 cases where CoQ10 reduced the effect of coumadin. No other cases have been reported.
It may be wise to monitor the prothrombin when supplementing with "AOR CoQ10 Plus".
AOR CoQ10 has been shown to be an effective aid for the support of cardiovascular disease and is a well-known antioxidant. AOR CoQ10 Plus is formulated with a superior lipid-based delivery system to ensure maximum absorption.
Coenzyme Q10
SKU Number: AOR04137
On Sale - AOR Supplements
UPC 0062491704137