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AOR, Bone Basics, 360 caps - Bone Basics is a multi-nutrient combination designed to support bone health, help in the development and maintenance of teeth, cartilage and gums and help in connective tissue formation and the maintenance of proper muscle function.
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AOR, Bone Basics, 360 caps

AOR Bone Basics - 360 caps
Bone Basics - 360 caps, aor vitamins supplements
AOR, Bone Basics, 360 caps is manufactured by AOR Supplements

Last updated on 12/5/2016

Bone Basics

  • Increases calcium absorption
  • Slows the rate of bone turnover
  • Stimulates bone building cells
  • Enhances joint and cartilage repair

Bone Basics is a multi-nutrient formula designed to support bone health. It features a hydroxyapatite complex (MCHC), an extract of bovine bone derived from New Zealand pasture-fed, free-range livestock not subjected to routine antibiotics or rBGH. Calcium intake, when combined with sufficient vitamin D, a healthy diet, and regular exercise, may reduce the risk of developing osteoporosis.

NPN Product Code Size Per Capsule Vegetarian
80030034 AOR04086 120 Capsules 399 mg
80030034 AOR04085 240 Capsules 399 mg
80030034 AOR04231 360 Capsules 399 mg
Supplement Facts
Serving Size: 6 Capsules


Calcium (from bone meal [MCHC]) * 1000 mg
Phosphorus (from bone meal [MCHC])* 455 mg
Boron (citrate) 700 mcg
Copper (citrate) 1 mg
Magnesium (citrate, oxide) 420 mg
Manganese (bisglycinate) 5 mg
Zinc (citrate) 11 mg
Vitamin C (ascorbic acid) 200 mg
Vitamin K2 120 mcg
- MK-4 60 mcg
- MK-7 (from soy) 60 mcg
Vitamin D3 (Cholecalciferol) 1000 IU (25 mcg)
Glucosamine Sulfate KCl (vegetarian) 300 mg

*Ossein Microcrystalline Hydroxyapatite Complex (MCHC) is lyophilized bone meal guaranteed free of bovine spongiform encephalopathy. Non-medicinal ingredients: tapioca dextrin, dicalcium phosphate. Capsule: hypromellose. 

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, peanuts, sulphites, mustard, dairy or eggs.

Adult Dosage: Take up to 6 capsules daily with meals, or as directed by a qualified health care practitioner.Take a few hours before or after taking other medications. Use for a minimum of 4 weeks to see beneficial effects.

Cautions: Consult a health care practitioner prior to use if you are taking blood thinners. Some people may experience diarrhea. Consult a health care practitioner if symptoms worsen.

Pregnancy/Nursing: Consult a health care practitioner prior to use.

Source:
MCHC & phosphorus - lyophilized, defatted bone tissue from free-range, pasture-fed New Zealand bovine livestock not subjected to routine antibiotics or rBGH. Guaranteed free of bovine spongiform encephalopathy;
Vitamin D3 - lanolin from sheep wool;
Glucosamine - New vegetarian source;
MK-7 - soy

Main Indications:

  • Excellent source of calcium and other nutrients
  • Bone health
  • Joint health

Research

Background Information

Multis Just Don’t Cut It
Traditional methods of maintaining bone health correlate with the efforts of health conscious individuals who supplement with a daily multi-vitamin/multi-mineral. Users of such an essential supplement (combined with a sensible diet) often assume that it covers something as elemental as bone health. The fact of the matter is that people in the high-risk demographic for developing osteopenia likely have a higher need for certain specific essential nutrients, especially minerals. Of these, calcium is certainly one of the most familiar. Most recommended daily allowances for calcium stand at around 1,000 milligrams, although 1,500 milligrams are recommended for those in the osteopenia high risk group. Even with the effects of processing taken into account, calcium is still prevalent to such a degree in common dairy foods such as milk and cheese that deficiencies are not as widespread as that of other minerals. Nevertheless, deficiencies do occur, and it is noteworthy to remember that even the finest multi-vitamin/multi-mineral one-a-days rarely contain more than 300 milligrams of calcium.

Bone Basics is a full-spectrum bone health formula that contains various nutrients at balanced doses in their most effective forms known to promote healthy bone formation and joints. Due to the type of calcium provided by Bone Basics, this formula not only slows bone loss but may even promote both growth. Bone Basics now contains both MK-4 and MK-7 as sources of Vitamin K2.

Calcium from MCHC

Read More

MCHC is a freeze-dried extract of bovine bone, and this process of lyophilization is important in retaining the intact microcrystalline structure of whole bone. This is a significant differentiation from regular bonemeal, which uses a heat-treated process called “ashing”. Many of the unique bone-building factors of MCHC are heat-sensitive and simply do not survive this process, and this has been demonstrated in clinical studies comparing MCHC directly to bonemeal. MCHC is, in effect, a full-spectrum multiple nutrient source in its own right. However, it is particularly rich in calcium, and the type of calcium in MCHC has been clinically proven in over 30 years of randomized, double-blind, controlled clinical trials to be the best calcium source for bone building and maintenance. Other calcium sources such as calcium gluconate, calcium citrate, calcium carbonate, calcium citrate-malate and even coral calcium (which in fact is simply calcium carbonate with a sprinkling of trace minerals) may be capable of slowing down the rate of bone loss. MCHC, in contrast, has actually been proven to halt and even reverse bone loss attributable to osteoporosis.

Glucosamine
Glucosamine is an aminomonosaccharide, meaning that it is the product of a synthesis between glucose and an amino acid – in this case, glutamine. Glucosamine sulfate is produced naturally in the body by chondrocytes in cartilage to help maintain and build healthy joint tissue. The main basic purpose of glucosamine is to create long chains of modified disaccharides called glycosaminoglycans (GAGs), which the joints and cartilage require for repair. The GAGs are the main component of proteoglycans (PGs), which along with chondrocytes and collagen, make up cartilage. Glucosamine is also converted in the body to N-acetyl-glucosamine, which in turn is critical to the formation of hyaluronic acid. Hyaluronic acid is the central component of synovial fluid which acts as a lubricant in the joints. Since the cartilage in the joints protects the bone ends, preserving the health of both is essential for good bone health. Bone Basics’ glucosamine source is now a vegetarian glucosamine sulfate, making it safe for those who avoid shellfish.

Vitamin D3
Bone Basics contains 1000 IU of vitamin D3 (cholecalciferol) per daily dose. Vitamin D is the single most important factor in the absorption of calcium. A superior form of vitamin D is vitamin D3 (also known as cholecalciferol), a colorless crystalline compound found in fish-liver oils. Research has shown that cholecalciferol is the preferred, active form of vitamin D in the body. Although humans are fully capable of endogenous vitamin D production, this is dependent upon adequate exposure to the UVB rays in sunlight, making a constant, steady intake of this vitamin difficult for high-risk demographics who are often confined indoors. This is compounded by the lack of sunlight in the winter months and in more extreme latitudes, further underlining the importance of supplementation.

Vitamin K2
Similarly to Vitamin D, Vitamin K2 is essential to absorbing and properly utilizing the calcium you ingest. Vitamin K2 helps shunt the calcium from the bloodstream into the bones. In fact, taking a lot of calcium without adequate vitamins D & K can be dangerous. Bone Basics contains vitamin K2 in the forms of MK-4 & MK-7, the most effective forms of these vitamins.

Vitamin C
Although Vitamin C has not been shown to prevent osteoporosis, women who consume higher levels of vitamin C tend to have higher bone density levels. Vitamin C helps product collagen, which is one of the main proteins in bone, and it helps heal fractures.

Magnesium
Magnesium is another mineral commonly associated with the maintenance of bone health, which is very easy to fathom when one considers that two-thirds of the body’s magnesium stores are located in our bone structure. Much of the magnesium within this bone structure is part of the bone’s crystal lattice (which can metaphorically be referred to as the “bone scaffolding”) where it binds together with the minerals phosphorus and calcium. Magnesium on its own has been shown to slow the rate of bone turnover, which is when the growth of new bone is outpaced by the degeneration of old. Magnesium shortages result in the reduced assimilation of vitamin D as well as the inhibition of parathyroid hormone, leading to low blood calcium levels. Magnesium also seems to work synergistically with MCHC (see below) by helping to form smaller, denser, microcrystalline hydroxyapatite crystals, providing yet another avenue for strong bone development. The amount of magnesium in even the highest quality multi-vitamin/multi-mineral supplements is still well below levels which researchers believe are needed for prevention in high risk demographics.

Trace Minerals: Zinc, Copper, Manganese & Boron
Several other minerals have also been identified as co-factors for enzymes involved in bone metabolism – notably zinc, copper, and manganese. The latter is essential for the proper function of the osteoblast cells that are responsible for building new bone. Manganese also increases the activity of the enzyme alkaline phosphatase and as well as growth factors such as estrogen and IGF-1 in a manner that is directly pertinent to these osteoblast cells. Copper is essential for producing an enzyme called lysyl oxidase which cross-links (strengthens) collagen. Zinc, in turn, is essential for the operation of copper, since unbalanced zinc intake can reduce copper absorption.

Another ingredient included in Bone Basics is boron, a mineral that at long last is in the process of being officially recognized as ‘essential’. Boron’s role regarding bone health appears to be mediated by its ability to reduce the urinary excretion of calcium and magnesium, thus enhancing vitamin D as well (which is directly interdependent with calcium). Boron’s mechanism of action takes place in the kidney.

Research

Calcium
MCHC is, in effect, a full-spectrum multiple nutrient source in its own right. However, it is particularly rich in calcium, and the type of calcium in MCHC has been clinically proven in over 30 years of randomized, double-blind, controlled clinical trials to be the best calcium source for bone building and maintenance.

Current “official” recommendations suggest an intake of 1000 milligrams of calcium for younger adults, and 1200 milligrams for people over the age of 50. Some evidence suggests that a still higher intake (1300-1600 milligrams) of calcium is more effective for lowering fracture risk in the elderly. But remember that these numbers are your total calcium need. The more calcium you get in your diet, the less you need from supplements.

A review published in 2012 cited that the most prevalent factors associated with both osteoporosis and atherosclerosis were low calcium intake, deficiencies in vitamins D & K, and high sodium intake. Clinical trials show that calcium supplementation provides better results when combined with vitamin D at doses greater than 300 IU per day.

A double-blind, controlled clinical trial on post-menopausal women examined the effects of a plain dairy product versus a dairy product enriched with 800 mg of calcium, 10 mcg of vitamin D and 100 mcg of either vitamin K1 or K2. While total bone mass density increased for all the dairy groups, lumbar spine bone mineral density increased significantly only in the two groups receiving the treatments enriched with calcium and vitamins D & K.

Read More

Vitamin D: 800 IUs +
From what we now know, the old RDA of 400 IU will not protect you from vitamin D insufficiency except in the sunniest of climates. Even in sunny Spain, researchers have found that 80% of children have inadequate vitamin D levels in March and October. In fact, in one remarkable recent study, researchers at Creighton University were able to document that even North Americans who spend nearly all day in the sun during the summer (such as landscapers and agricultural workers) were still at a 58% risk of being too low in vitamin D to support optimal calcium metabolism by the end of the winter! Studies show that a 400 IU vitamin D supplement is just not enough to keep serum levels of the active vitamin above the cutoff for insufficiency, and the use of 400 IU supplements have not been shown to reduce fracture rates. Even 600 IU has little effect on BMD. Instead, controlled studies show that vitamin D, together with calcium, helps to reduce the risk of fracture at a dose of at least 800 IU per day and recent trials suggest much higher dosages are needed to maintain optimal blood levels.

Vitamin K2
Recent studies have suggested that vitamin K2 is better absorbed and persists longer in the plasma then vitamin K1. Studies have also shown that it also has greater benefits to the skeletal and vascular systems than vitamin K1. Vitamin K is important for bone health as it is able to regulate calcium through the amino acid gamma-carboxyglutamic acid (Gla), and in particular the protein osteocalcin, which helps maintain calcium in bone, but at the same time keeps it out of soft tissue.

The advantages of taking both MK-4 and MK-7
More recently, Vitamin K2 in the forms of MK-4 and MK-7 has emerged as bone-building superstars.  MK-4 is a specific form of vitamin K2 produced in the body from phylloquinone (vitamin K1) or even the bacterial menaquinones (which are also forms of vitamin K2). It is thought that other forms of vitamin K are converted to MK-4 in order to be absorbed by cells. Multiple clinical trials show that megadose MK-4 supplements reduce fracture rates in osteoporotic women as much as Fosamax®-type drugs by improving the quality of the bone itself, measured by bone mineral content and width. Another study found that MK-4 combined with 1500 mg of calcium carbonate significantly increased bone density in the lumbar spine and decreased the amount of undercarboxylated osteocalcin compared to just the 1500 mg of calcium alone.

In a recent study comparing MK-4 against MK-7, one of the first actually comparing the two head-to-head, it was found that when subjects took a single dose administration of 420 μg of MK-4 or MK-7, the MK-7 was well absorbed and reached maximal serum level at 6 h after intake and was detected up to 48 h after intake. MK-4 was not detectable in the serum of all subjects at any time point. It is not yet clear whether this is because MK-4 was metabolized very quickly (some nutrients actually benefit from a short half-life) or because it was not absorbed. Consecutive administration of MK-7 at 60 μg for 7 days demonstrated that MK-7 increased serum MK-7 levels significantly in all subjects and activated osteocalcin at this dose. Further research is warranted on the benefits of both forms of vitamin K2, as MK-4 has shown many beneficial effects in humans that have not yet been studied with MK-7 (for example, liver cancer), and there appears to be a cellular receptor specific to MK-4 in humans. Therefore, AOR has chosen to provide both MK-4 and MK-7 in Ortho•Bone to maximize the potential benefits of each.

Absorbable Magnesium
Take a magnesium you can absorb. Magnesium citrate is absorbed at 29.64%, but much better absorption is available from other forms – especially fully-reacted magnesium aspartate, with a remarkable 41.7% bioavailability.

In a two-year, open, controlled trial, 71% of women receiving magnesium supplements experienced increased bone mineral density whereas the women not receiving supplements suffered bone loss. The amount of magnesium in even the highest quality multi-vitamin/multi-mineral supplements is still well below levels which researchers believe are needed for prevention in high risk demographics.

Boron
In a clinical study among 12 post-menopausal women not on estrogen replacement therapy, boron was not only shown to significantly diminish urinary losses of calcium and magnesium, but it also raised levels of plasma ionized calcium, beta-estradiol, and testosterone.

Market Trends

Multivitamins do provide an array of nutrients necessary for good health. Unfortunately, they just don’t provide enough of most nutrients for people with specific needs. For those at risk of bone disorders, certain vitamins and minerals are more important.

Calcium supplements and Vitamin D are number one sellers among post-menopausal women and seniors, yet osteoporotic fracture incidences continue to rise at an alarming rate. What else is missing?

Read More

Vitamin K has recently joined the bone health bandwagon. Vitamin K2 is as important for good bone health as vitamin D, since Vitamins D & K help the body to absorb and utilize calcium effectively. But is there still more?

Calcium has recently gotten a bad reputation for contributing to heart disease. Of course too much of a good thing is never a good thing. Excessive calcium consumption without sufficient amounts of vitamins D & K can cause a build-up of calcium in the bloodstream, without actually being taken up into bone tissue. It is imperative that adequate calcium, vitamin D and vitamin K be taken together in order for them to support bone health. In addition, fast-release calcium salts (such as calcium citrate) pose more of a threat to arterial health than food sourced calcium such as in MCHC due to the amount of calcium being dumped into the bloodstream at once.

AOR Advantage

Bone Basics provides the ideal source of MCHC which is pasture-fed, free-range livestock not subjected to routine antibiotics or recombinant bovine growth hormone (rBGH). This not only ensures that the widest possible range of micronutrients within the whole bone extract survive the manufacturing process, but it would also provide assurances against bovine spongiform encephalopathy, commonly referred to as mad cow disease. The most reputable sources of such livestock appear to be from Australian, New Zealand and Argentine pastures, where local legislation and/or custom either prohibits, limits or discourages routine antibiotics and recombinant bovine growth hormone (rBGH).

MCHC provides all the nutrients found in bones as well as proteins, which function as growth factors, actually stimulating bone development rather than just reducing calcium loss.

Read More

Vitamin K2 as MK-4 and MK-7 are two forms of vitamin K used by the human body.

Vitamin D3 is the most absorbable form of vitamin D.

Provides other minerals known to contribute to bone health.

Provides a vegetarian glucosamine sulfate to support the joints, since the joints are usually affected when bone health declines.



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