AOR, Bone Basics, 360 caps
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Bone Basics - 360 caps, aor vitamins supplements
AOR, Bone Basics, 360 caps is manufactured by AOR Supplements
- Increases calcium absorption
- Slows the rate of bone turnover
- Stimulates bone building cells
- Enhances joint and cartilage repair
Bone Basics is a multi-nutrient formula designed to support bone health. It features a hydroxyapatite
complex (MCHC), an extract of bovine bone derived from New Zealand
pasture-fed, free-range livestock not subjected to routine antibiotics
or rBGH. Calcium intake, when combined with sufficient vitamin D, a
healthy diet, and regular exercise, may reduce the risk of developing
|Serving Size: 6 Capsules
|Calcium (from bone meal [MCHC]) *
|Phosphorus (from bone meal [MCHC])*
|Magnesium (citrate, oxide)
|Vitamin C (ascorbic acid)
|- MK-7 (from soy)
|Vitamin D3 (Cholecalciferol)
||1000 IU (25 mcg)
|Glucosamine Sulfate KCl (vegetarian)
Microcrystalline Hydroxyapatite Complex (MCHC) is lyophilized bone meal
guaranteed free of bovine spongiform encephalopathy. Non-medicinal
ingredients: tapioca dextrin, dicalcium phosphate. Capsule: hypromellose.
that no ingredients not listed on the label have been added to the
product. Contains no wheat, gluten, peanuts, sulphites, mustard, dairy
Take up to 6 capsules daily with meals, or as directed by a qualified
health care practitioner.Take a few hours before or after taking other
medications. Use for a minimum of 4 weeks to see beneficial effects.
Consult a health care practitioner prior to use if you are taking blood
thinners. Some people may experience diarrhea. Consult a health care
practitioner if symptoms worsen.
Pregnancy/Nursing: Consult a health care practitioner prior to use.
MCHC & phosphorus - lyophilized, defatted bone tissue from
free-range, pasture-fed New Zealand bovine livestock not subjected to
routine antibiotics or rBGH. Guaranteed free of bovine spongiform
Vitamin D3 - lanolin from sheep wool;
Glucosamine - New vegetarian source;
MK-7 - soy
- Excellent source of calcium and other nutrients
- Bone health
- Joint health
Multis Just Don’t Cut It
methods of maintaining bone health correlate with the efforts of health
conscious individuals who supplement with a daily
multi-vitamin/multi-mineral. Users of such an essential supplement
(combined with a sensible diet) often assume that it covers something as
elemental as bone health. The fact of the matter is that people in the
high-risk demographic for developing osteopenia likely have a higher
need for certain specific essential nutrients, especially minerals. Of
these, calcium is certainly one of the most familiar. Most recommended
daily allowances for calcium stand at around 1,000 milligrams, although
1,500 milligrams are recommended for those in the osteopenia high risk
group. Even with the effects of processing taken into account, calcium
is still prevalent to such a degree in common dairy foods such as milk
and cheese that deficiencies are not as widespread as that of other
minerals. Nevertheless, deficiencies do occur, and it is noteworthy to
remember that even the finest multi-vitamin/multi-mineral one-a-days
rarely contain more than 300 milligrams of calcium.
is a full-spectrum bone health formula that contains various nutrients
at balanced doses in their most effective forms known to promote healthy
bone formation and joints. Due to the type of calcium provided by Bone
Basics, this formula not only slows bone loss but may even promote both
growth. Bone Basics now contains both MK-4 and MK-7 as sources of
Calcium from MCHC
is a freeze-dried extract of bovine bone, and this process of
lyophilization is important in retaining the intact microcrystalline
structure of whole bone. This is a significant differentiation from
regular bonemeal, which uses a heat-treated process called “ashing”.
Many of the unique bone-building factors of MCHC are heat-sensitive and
simply do not survive this process, and this has been demonstrated in
clinical studies comparing MCHC directly to bonemeal. MCHC is, in
effect, a full-spectrum multiple nutrient source in its own right.
However, it is particularly rich in calcium, and the type of calcium in
MCHC has been clinically proven in over 30 years of randomized,
double-blind, controlled clinical trials to be the best calcium source
for bone building and maintenance. Other calcium sources such as calcium
gluconate, calcium citrate, calcium carbonate, calcium citrate-malate
and even coral calcium (which in fact is simply calcium carbonate with a
sprinkling of trace minerals) may be capable of slowing down the rate
of bone loss. MCHC, in contrast, has actually been proven to halt and
even reverse bone loss attributable to osteoporosis.
is an aminomonosaccharide, meaning that it is the product of a
synthesis between glucose and an amino acid – in this case, glutamine.
Glucosamine sulfate is produced naturally in the body by chondrocytes in
cartilage to help maintain and build healthy joint tissue. The main
basic purpose of glucosamine is to create long chains of modified
disaccharides called glycosaminoglycans (GAGs), which the joints and
cartilage require for repair. The GAGs are the main component of
proteoglycans (PGs), which along with chondrocytes and collagen, make up
cartilage. Glucosamine is also converted in the body to
N-acetyl-glucosamine, which in turn is critical to the formation of
hyaluronic acid. Hyaluronic acid is the central component of synovial
fluid which acts as a lubricant in the joints. Since the cartilage in
the joints protects the bone ends, preserving the health of both is
essential for good bone health. Bone Basics’ glucosamine source is now a
vegetarian glucosamine sulfate, making it safe for those who avoid
Bone Basics contains
1000 IU of vitamin D3 (cholecalciferol) per daily dose. Vitamin D is the
single most important factor in the absorption of calcium. A superior
form of vitamin D is vitamin D3 (also known as cholecalciferol), a
colorless crystalline compound found in fish-liver oils. Research has
shown that cholecalciferol is the preferred, active form of vitamin D in
the body. Although humans are fully capable of endogenous vitamin D
production, this is dependent upon adequate exposure to the UVB rays in
sunlight, making a constant, steady intake of this vitamin difficult for
high-risk demographics who are often confined indoors. This is
compounded by the lack of sunlight in the winter months and in more
extreme latitudes, further underlining the importance of
Similarly to Vitamin D,
Vitamin K2 is essential to absorbing and properly utilizing the calcium
you ingest. Vitamin K2 helps shunt the calcium from the bloodstream into
the bones. In fact, taking a lot of calcium without adequate vitamins D
& K can be dangerous. Bone Basics contains vitamin K2 in the forms
of MK-4 & MK-7, the most effective forms of these vitamins.
Vitamin C has not been shown to prevent osteoporosis, women who consume
higher levels of vitamin C tend to have higher bone density levels.
Vitamin C helps product collagen, which is one of the main proteins in
bone, and it helps heal fractures.
is another mineral commonly associated with the maintenance of bone
health, which is very easy to fathom when one considers that two-thirds
of the body’s magnesium stores are located in our bone structure. Much
of the magnesium within this bone structure is part of the bone’s
crystal lattice (which can metaphorically be referred to as the “bone
scaffolding”) where it binds together with the minerals phosphorus and
calcium. Magnesium on its own has been shown to slow the rate of bone
turnover, which is when the growth of new bone is outpaced by the
degeneration of old. Magnesium shortages result in the reduced
assimilation of vitamin D as well as the inhibition of parathyroid
hormone, leading to low blood calcium levels. Magnesium also seems to
work synergistically with MCHC (see below) by helping to form smaller,
denser, microcrystalline hydroxyapatite crystals, providing yet another
avenue for strong bone development. The amount of magnesium in even the
highest quality multi-vitamin/multi-mineral supplements is still well
below levels which researchers believe are needed for prevention in high
Trace Minerals: Zinc, Copper, Manganese & Boron
other minerals have also been identified as co-factors for enzymes
involved in bone metabolism – notably zinc, copper, and manganese. The
latter is essential for the proper function of the osteoblast cells that
are responsible for building new bone. Manganese also increases the
activity of the enzyme alkaline phosphatase and as well as growth
factors such as estrogen and IGF-1 in a manner that is directly
pertinent to these osteoblast cells. Copper is essential for producing
an enzyme called lysyl oxidase which cross-links (strengthens) collagen.
Zinc, in turn, is essential for the operation of copper, since
unbalanced zinc intake can reduce copper absorption.
ingredient included in Bone Basics is boron, a mineral that at long last
is in the process of being officially recognized as ‘essential’.
Boron’s role regarding bone health appears to be mediated by its ability
to reduce the urinary excretion of calcium and magnesium, thus
enhancing vitamin D as well (which is directly interdependent with
calcium). Boron’s mechanism of action takes place in the kidney.
MCHC is, in effect, a full-spectrum multiple nutrient source in its own
right. However, it is particularly rich in calcium, and the type of
calcium in MCHC has been clinically proven in over 30 years of
randomized, double-blind, controlled clinical trials to be the best
calcium source for bone building and maintenance.
“official” recommendations suggest an intake of 1000 milligrams of
calcium for younger adults, and 1200 milligrams for people over the age
of 50. Some evidence suggests that a still higher intake (1300-1600
milligrams) of calcium is more effective for lowering fracture risk in
the elderly. But remember that these numbers are your total calcium
need. The more calcium you get in your diet, the less you need from
A review published in 2012 cited that the most
prevalent factors associated with both osteoporosis and atherosclerosis
were low calcium intake, deficiencies in vitamins D & K, and high
sodium intake. Clinical trials show that calcium supplementation
provides better results when combined with vitamin D at doses greater
than 300 IU per day.
A double-blind, controlled clinical trial on
post-menopausal women examined the effects of a plain dairy product
versus a dairy product enriched with 800 mg of calcium, 10 mcg of
vitamin D and 100 mcg of either vitamin K1 or K2. While total bone mass
density increased for all the dairy groups, lumbar spine bone mineral
density increased significantly only in the two groups receiving the
treatments enriched with calcium and vitamins D & K.
Vitamin D: 800 IUs +
From what we now know, the old RDA of 400 IU will not protect you from
vitamin D insufficiency except in the sunniest of climates. Even in
sunny Spain, researchers have found that 80% of children have inadequate
vitamin D levels in March and October. In fact, in one remarkable
recent study, researchers at Creighton University were able to document
that even North Americans who spend nearly all day in the sun during the
summer (such as landscapers and agricultural workers) were still at a
58% risk of being too low in vitamin D to support optimal calcium
metabolism by the end of the winter! Studies show that a 400 IU vitamin D
supplement is just not enough to keep serum levels of the active
vitamin above the cutoff for insufficiency, and the use of 400 IU
supplements have not been shown to reduce fracture rates. Even 600 IU
has little effect on BMD. Instead, controlled studies show that vitamin
D, together with calcium, helps to reduce the risk of fracture at a dose
of at least 800 IU per day and recent trials suggest much higher
dosages are needed to maintain optimal blood levels.
studies have suggested that vitamin K2 is better absorbed and persists
longer in the plasma then vitamin K1. Studies have also shown that it
also has greater benefits to the skeletal and vascular systems than
vitamin K1. Vitamin K is important for bone health as it is able to
regulate calcium through the amino acid gamma-carboxyglutamic acid
(Gla), and in particular the protein osteocalcin, which helps maintain
calcium in bone, but at the same time keeps it out of soft tissue.
The advantages of taking both MK-4 and MK-7
More recently, Vitamin K2 in the forms of MK-4 and MK-7 has emerged as
bone-building superstars. MK-4 is a specific form of vitamin K2
produced in the body from phylloquinone (vitamin K1) or even the
bacterial menaquinones (which are also forms of vitamin K2). It is
thought that other forms of vitamin K are converted to MK-4 in order to
be absorbed by cells. Multiple clinical trials show that megadose MK-4
supplements reduce fracture rates in osteoporotic women as much as
Fosamax®-type drugs by improving the quality of the bone itself,
measured by bone mineral content and width. Another study found that
MK-4 combined with 1500 mg of calcium carbonate significantly increased
bone density in the lumbar spine and decreased the amount of
undercarboxylated osteocalcin compared to just the 1500 mg of calcium
In a recent study comparing MK-4 against MK-7, one of the
first actually comparing the two head-to-head, it was found that when
subjects took a single dose administration of 420 μg of MK-4 or MK-7,
the MK-7 was well absorbed and reached maximal serum level at 6 h after
intake and was detected up to 48 h after intake. MK-4 was not detectable
in the serum of all subjects at any time point. It is not yet clear
whether this is because MK-4 was metabolized very quickly (some
nutrients actually benefit from a short half-life) or because it was not
absorbed. Consecutive administration of MK-7 at 60 μg for 7 days
demonstrated that MK-7 increased serum MK-7 levels significantly in all
subjects and activated osteocalcin at this dose. Further research is
warranted on the benefits of both forms of vitamin K2, as MK-4 has shown
many beneficial effects in humans that have not yet been studied with
MK-7 (for example, liver cancer), and there appears to be a cellular
receptor specific to MK-4 in humans. Therefore, AOR has chosen to
provide both MK-4 and MK-7 in Ortho•Bone to maximize the potential
benefits of each.
Take a magnesium
you can absorb. Magnesium citrate is absorbed at 29.64%, but much
better absorption is available from other forms – especially
fully-reacted magnesium aspartate, with a remarkable 41.7%
In a two-year, open, controlled trial, 71% of
women receiving magnesium supplements experienced increased bone mineral
density whereas the women not receiving supplements suffered bone loss.
The amount of magnesium in even the highest quality
multi-vitamin/multi-mineral supplements is still well below levels which
researchers believe are needed for prevention in high risk
In a clinical study among 12
post-menopausal women not on estrogen replacement therapy, boron was not
only shown to significantly diminish urinary losses of calcium and
magnesium, but it also raised levels of plasma ionized calcium,
beta-estradiol, and testosterone.
do provide an array of nutrients necessary for good health.
Unfortunately, they just don’t provide enough of most nutrients for
people with specific needs. For those at risk of bone disorders, certain
vitamins and minerals are more important.
Calcium supplements and
Vitamin D are number one sellers among post-menopausal women and
seniors, yet osteoporotic fracture incidences continue to rise at an
alarming rate. What else is missing?
K has recently joined the bone health bandwagon. Vitamin K2 is as
important for good bone health as vitamin D, since Vitamins D & K
help the body to absorb and utilize calcium effectively. But is there
Calcium has recently gotten a bad reputation for
contributing to heart disease. Of course too much of a good thing is
never a good thing. Excessive calcium consumption without sufficient
amounts of vitamins D & K can cause a build-up of calcium in the
bloodstream, without actually being taken up into bone tissue. It is
imperative that adequate calcium, vitamin D and vitamin K be taken
together in order for them to support bone health. In addition,
fast-release calcium salts (such as calcium citrate) pose more of a
threat to arterial health than food sourced calcium such as in MCHC due
to the amount of calcium being dumped into the bloodstream at once.
Basics provides the ideal source of MCHC which is pasture-fed,
free-range livestock not subjected to routine antibiotics or recombinant
bovine growth hormone (rBGH). This not only ensures that the widest
possible range of micronutrients within the whole bone extract survive
the manufacturing process, but it would also provide assurances against
bovine spongiform encephalopathy, commonly referred to as mad cow
disease. The most reputable sources of such livestock appear to be from
Australian, New Zealand and Argentine pastures, where local legislation
and/or custom either prohibits, limits or discourages routine
antibiotics and recombinant bovine growth hormone (rBGH).
provides all the nutrients found in bones as well as proteins, which
function as growth factors, actually stimulating bone development rather
than just reducing calcium loss.
Vitamin K2 as MK-4 and MK-7 are two forms of vitamin K used by the human body.
Vitamin D3 is the most absorbable form of vitamin D.
Provides other minerals known to contribute to bone health.
a vegetarian glucosamine sulfate to support the joints, since the
joints are usually affected when bone health declines.
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