AOR, Biofolate, 1mg, 30 caps
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Bio Folate - 30 caps, aor vitamins supplements
AOR, Biofolate, 1mg, 30 caps is manufactured by AOR Supplements
- Promotes cardiovascular health
- Reduces the risk of cancer
- Required for DNA synthesis
- Important during pregnancy
BioFolate contains the preferred,
biologically active form of folate that is produced in the body.
BioFolate helps the body to metabolize carbohydrates, fats, and proteins
and form red blood cells.
|Serving Size: 1 Capsule
|Vitamin B12 (methylcobalamin)
|Non-medicinal ingredients: microcrystalline cellulose, silicon dioxide. Capsule: hypromellose, chlorophyll.
that no ingredients not listed on the label have been added to the
product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish,
shellfish or any animal byproducts.
Take 1 capsule per day with food, or as directed by a qualified health
care practitioner. Folate supplementation can mask a vitamin B12
Cautions: Consult a health care practitioner prior to use if you are uncertain whether or not you are taking adequate vitamin B12.
Pregnancy/Nursing: Consult a health care practitioner
- Megaloblastic anemia
- Cardiovascular health
- Neural tube defects
acid (or folate) is a water-soluble vitamin that plays a key role in
the biosynthesis of DNA and RNA, red blood cell production and the
metabolization of proteins. Folic acid is also necessary for genome
maintenance, the regulation of gene expression, and other functions.
Natural folates are found in dark green leafy vegetables (spinach, kale,
mustard greens, turnip greens) as well as oranges, broccoli,
cauliflower, liver and brewer’s yeast. The absorption efficiency of
natural folates is approximately 50% that of supplemental folic acid.
This is because natural food folates are pteroylpolyglutamate
derivatives. These require cleavage (by an enzyme called folate
conjugase) to pteroylmonoglutamate forms prior to absorption from the
acid (in supplemental form) is already a pteroylmonoglutamate and
therefore does not require this process, making it much more efficiently
absorbed as a result. When most health practitioners and astute
observers of preventative health and nutrition think of folic acid, they
refer to the overwhelming amount of research supporting folic acid’s
ability to prevent neural tube defects. So strong is this evidence, in
fact, that even the highly reticent U.S. Food & Drug Administration
began enforcing a regulation in 1998 that required all uncooked flour,
grain and cereal products to be fortified with folic acid. It is safe to
say that nutrient fortification is legislated on a highly reactionary,
sporadic and admonitory basis, and for folic acid to achieve this kind
of legislative recognition speaks volumes in and of itself.
Deficiency & Implications
deficiency in dietary folate has wide-ranging implications over and
above the risk of aforementioned neural tube defects among expectant and
potential mothers. Such implications can include weakness, fatigue,
irritability, headaches, difficulties in cognitive function, cramps,
palpitations, shortness of breath and atrophic glossitis.
have also revealed that low folate levels are linked to elevated serum
homocysteine concentration, hypersegmentation of the neutrophils, and
decreased hemogloblin and erythrocyte concentrations. Folate
deficiencies have also been linked to increased risks of cardiovascular
disease, certain types of cancer, Alzheimer’s disease and depression. A
number of conditions can lead to folate deficiency. Chronic alcohol
users can become deficient in the vitamin due in part to ethanol’s
impairment of folate absorption and hepatobiliary metabolism, as well as
to increased renal folate excretion caused by ethanol. Crohn’s disease,
lymphoma or amyloidosis of the small intestine, diabetic enteropathy,
and tropical and non-tropical sprue (gluten-sensitive enteropathy) can
also result in folate deficiency. Some conditions or situations such as
chronic hemolytic anemias (e.g., sickle cell disease), chronic
hemodialysis, peritoneal dialysis, chronic exfoliative skin disorders
and of course pregnancy, all cause an increased demand for folate.
Homocysteine & Heart Health
acid’s critical role in converting homocysteine back to methionine
gives it the potential to address many of the myriad of health
conditions that are initiated by high homocysteine levels. One
meta-analysis determined that folate supplementation reduced plasma
homocysteine levels in a dose-dependent fashion. Based upon findings
from this meta-analysis, it has been estimated that for every 50
microgram daily increase in average folic acid intake, 4,000 to 18,000
deaths due to cardiovascular disease could be prevented annually in the
U.S. alone. It has also been demonstrated in a prospective, randomized,
placebo-controlled trial that high-dose folic acid supplementation (10
mg daily for two weeks) can help prevent some of the deleterious effects
of triglyceride-rich lipoproteins on endothelium-dependent vasodilation
in healthy volunteers challenged with an acute oral fat load. In
another study, this one among 45 subjects with established
cardiovascular disease, folic acid intake was significantly inversely
associated with multiple indices of oxidized LDL-cholesterol. This
correlation remained significant even when adjusted for potential
confounding variables, including consumption of other vitamins and
Folate and Cancer
acid also appears to protect against a number of cancers, particularly
colorectal cancer. Some 20 epidemiologic studies suggest that people
with the highest folate intake have an approximately 40% reduction in
the risk of this cancer. In one sweeping study involving 88,756 women,
there was a 75% reduction in colorectal cancer risk among those using
multivitamin supplements containing 400 mcg or more of folic acid for 15
or more years, compared with those not using these supplements. Once
again, this benefit was calculated even after controlling for all
relevant potential confounding factors, including consumption of other
vitamins, minerals and nutrients. Long-term folate supplementation was
also found, in another study, to reduce the incidence of colorectal
neoplasia by 62% in subjects with extensive chronic ulcerative colitis.
Such subjects, without this supplementation, typically have a 10-fold to
40-fold increased risk of developing colorectal neoplasia.
Epidemiological studies also demonstrate a useful role for folic acid in
preventing cancers of the brain, stomach and esophagus. Folic acid
therapy for cervical dysplasia is also well-established.
Does Folate Promote Tumour Growth?
important consensus was reached in a 2007 review on folate
supplementation and cancer, namely that ‘timing was everything’. The
authors of the review stated that while evidence for the preventative
capacity of folate with regard to tumour development was extensive, it
would also appear that folate supplementation after the establishment of
early lesions can in fact increase tumourigenesis, partially explaining
the chemoprotective potential of antifolate drugs. Possible
explanations include the fact that like all cells, tumour cells also
benefit from DNA and RNA biosynthesis – one of folic acid’s fundamental
roles. There remained, however, a considerable amount of consensus in
the anti-carcinogenic value of folate within the framework of
multi-faceted intervention and proper timing.
Folate (or folic acid) is known as the main supplement during pregnancy to prevent neural tube defects in the fetus.
is also now known that about 20% of the population has a genetic
mutation that makes their bodies unable to convert dietary folate to its
active form, L-5-MTHF (methyl-tetra-hydro-folate), making
supplementation with the active form very important for this sub-group
Biofolate provides a high dose of the active form of folate combined
with a minimal amount of active B12, because folate supplementation can
mask a B12 deficiency.
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