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AOR, Biofolate, 1mg, 30 caps - BioFolate contains the preferred, biologically active form of folate that is produced in the body. Folate is essential for DNA biosynthesis and for the methylation cycle. Low levels of folate have been associated with cardiovascular disease, colon cancer,
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AOR, Biofolate, 1mg, 30 caps

AOR Bio Folate - 30 caps
Bio Folate - 30 caps, aor vitamins supplements
AOR, Biofolate, 1mg, 30 caps is manufactured by AOR Supplements

Last updated on 12/5/2016

BioFolate

  • Promotes cardiovascular health
  • Reduces the risk of cancer
  • Required for DNA synthesis
  • Important during pregnancy

BioFolate contains the preferred, biologically active form of folate that is produced in the body. BioFolate helps the body to metabolize carbohydrates, fats, and proteins and form red blood cells.

NPN Product Code Size Per Capsule Vegetarian
80030511 AOR04176 30 Vegi-Caps 1 mg Vegetarian
Supplement Facts
Serving Size: 1 Capsule


L-5-Methyltetrahydrofolate 1 mg
Vitamin B12 (methylcobalamin) 2.4 mcg

Non-medicinal ingredients: microcrystalline cellulose, silicon dioxide. Capsule: hypromellose, chlorophyll.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, shellfish or any animal byproducts.

Adult Dosage: Take 1 capsule per day with food, or as directed by a qualified health care practitioner. Folate supplementation can mask a vitamin B12 deficiency.

Cautions: Consult a health care practitioner prior to use if you are uncertain whether or not you are taking adequate vitamin B12.

Pregnancy/Nursing: Consult a health care practitioner

Source:
Pharmaceutical synthesis

Main Indications:

  • Megaloblastic anemia
  • Methylation
  • Cardiovascular health
  • Neural tube defects

Research

Background Information

Natural Folate
Folic acid (or folate) is a water-soluble vitamin that plays a key role in the biosynthesis of DNA and RNA, red blood cell production and the metabolization of proteins. Folic acid is also necessary for genome maintenance, the regulation of gene expression, and other functions. Natural folates are found in dark green leafy vegetables (spinach, kale, mustard greens, turnip greens) as well as oranges, broccoli, cauliflower, liver and brewer’s yeast. The absorption efficiency of natural folates is approximately 50% that of supplemental folic acid. This is because natural food folates are pteroylpolyglutamate derivatives. These require cleavage (by an enzyme called folate conjugase) to pteroylmonoglutamate forms prior to absorption from the small intestine.

Supplemental folate
Folic acid (in supplemental form) is already a pteroylmonoglutamate and therefore does not require this process, making it much more efficiently absorbed as a result. When most health practitioners and astute observers of preventative health and nutrition think of folic acid, they refer to the overwhelming amount of research supporting folic acid’s ability to prevent neural tube defects. So strong is this evidence, in fact, that even the highly reticent U.S. Food & Drug Administration began enforcing a regulation in 1998 that required all uncooked flour, grain and cereal products to be fortified with folic acid. It is safe to say that nutrient fortification is legislated on a highly reactionary, sporadic and admonitory basis, and for folic acid to achieve this kind of legislative recognition speaks volumes in and of itself.

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Deficiency & Implications
A deficiency in dietary folate has wide-ranging implications over and above the risk of aforementioned neural tube defects among expectant and potential mothers. Such implications can include weakness, fatigue, irritability, headaches, difficulties in cognitive function, cramps, palpitations, shortness of breath and atrophic glossitis.

Studies have also revealed that low folate levels are linked to elevated serum homocysteine concentration, hypersegmentation of the neutrophils, and decreased hemogloblin and erythrocyte concentrations. Folate deficiencies have also been linked to increased risks of cardiovascular disease, certain types of cancer, Alzheimer’s disease and depression. A number of conditions can lead to folate deficiency. Chronic alcohol users can become deficient in the vitamin due in part to ethanol’s impairment of folate absorption and hepatobiliary metabolism, as well as to increased renal folate excretion caused by ethanol. Crohn’s disease, lymphoma or amyloidosis of the small intestine, diabetic enteropathy, and tropical and non-tropical sprue (gluten-sensitive enteropathy) can also result in folate deficiency. Some conditions or situations such as chronic hemolytic anemias (e.g., sickle cell disease), chronic hemodialysis, peritoneal dialysis, chronic exfoliative skin disorders and of course pregnancy, all cause an increased demand for folate.

Research

Homocysteine & Heart Health
Folic acid’s critical role in converting homocysteine back to methionine gives it the potential to address many of the myriad of health conditions that are initiated by high homocysteine levels. One meta-analysis determined that folate supplementation reduced plasma homocysteine levels in a dose-dependent fashion. Based upon findings from this meta-analysis, it has been estimated that for every 50 microgram daily increase in average folic acid intake, 4,000 to 18,000 deaths due to cardiovascular disease could be prevented annually in the U.S. alone. It has also been demonstrated in a prospective, randomized, placebo-controlled trial that high-dose folic acid supplementation (10 mg daily for two weeks) can help prevent some of the deleterious effects of triglyceride-rich lipoproteins on endothelium-dependent vasodilation in healthy volunteers challenged with an acute oral fat load. In another study, this one among 45 subjects with established cardiovascular disease, folic acid intake was significantly inversely associated with multiple indices of oxidized LDL-cholesterol. This correlation remained significant even when adjusted for potential confounding variables, including consumption of other vitamins and nutrients.

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Folate and Cancer
Folic acid also appears to protect against a number of cancers, particularly colorectal cancer. Some 20 epidemiologic studies suggest that people with the highest folate intake have an approximately 40% reduction in the risk of this cancer. In one sweeping study involving 88,756 women, there was a 75% reduction in colorectal cancer risk among those using multivitamin supplements containing 400 mcg or more of folic acid for 15 or more years, compared with those not using these supplements. Once again, this benefit was calculated even after controlling for all relevant potential confounding factors, including consumption of other vitamins, minerals and nutrients. Long-term folate supplementation was also found, in another study, to reduce the incidence of colorectal neoplasia by 62% in subjects with extensive chronic ulcerative colitis. Such subjects, without this supplementation, typically have a 10-fold to 40-fold increased risk of developing colorectal neoplasia. Epidemiological studies also demonstrate a useful role for folic acid in preventing cancers of the brain, stomach and esophagus. Folic acid therapy for cervical dysplasia is also well-established.

Does Folate Promote Tumour Growth?
An important consensus was reached in a 2007 review on folate supplementation and cancer, namely that ‘timing was everything’. The authors of the review stated that while evidence for the preventative capacity of folate with regard to tumour development was extensive, it would also appear that folate supplementation after the establishment of early lesions can in fact increase tumourigenesis, partially explaining the chemoprotective potential of antifolate drugs. Possible explanations include the fact that like all cells, tumour cells also benefit from DNA and RNA biosynthesis – one of folic acid’s fundamental roles. There remained, however, a considerable amount of consensus in the anti-carcinogenic value of folate within the framework of multi-faceted intervention and proper timing.

Market Trends

Folate (or folic acid) is known as the main supplement during pregnancy to prevent neural tube defects in the fetus.

It is also now known that about 20% of the population has a genetic mutation that makes their bodies unable to convert dietary folate to its active form, L-5-MTHF (methyl-tetra-hydro-folate), making supplementation with the active form very important for this sub-group of people.

AOR Advantage

AOR’s Biofolate provides a high dose of the active form of folate combined with a minimal amount of active B12, because folate supplementation can mask a B12 deficiency.



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