AOR, Benfotiamine, 120 vcaps
Cureself Customer Service
Benfotiamine - 120 vcaps, aor vitamins supplements
AOR, Benfotiamine, 120 vcaps is manufactured by AOR Supplements
- Blocks the formation of harmful sugar products
- Supports nerve function in diabetics
- Helps prevent retinal damage
Benfotiamine is a naturally-occurring form of
thiamin (vitamin B1). Benfotiamine's superior ability to penetrate cell
membranes increases its bioavailability over conventional thiamin
supplements. This allows for the use of benfotiamine to elicit all of
the benefits of vitamin B1, such as the metabolism of carbohydrates,
protein and fat, in a highly efficient manner.
|Serving Size: 1 Capsule
|Amount Per Serving
|Non-medicinal ingredients: microcrystalline cellulose. Capsule: hypromellose.
that no ingredients not listed on the label have been added to the
product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish
Adult Dosage: Take 1 capsule daily with food, or as directed by a health care practitioner.
Cautions: Persons with thiamine hypersensitivity should not take this product.
Pregnancy/Nursing: No studies have been conducted. Best to avoid.
- AGE Inhibitor
- Brain Support
- Thiamin Deficiency
The “Caramelization of the Flesh”
Glycation Endproducts, or “AGEs” as they’re appropriately called, are
the end result of the complex chemical process through which the
structure of proteins is warped by exposure to sugars or by other, much
more reactive molecules. AGE chemistry is the cause of the “browning”
you see when you roast a chicken or make toast, but the same “browning”
chemistry is at work in your body every day of your life. In your
arteries. In your kidneys. In your heart, your eyes, your skin, your
nerves. In every cell, the sugar that your body uses for fuel is busily
at work at this very moment, caramelizing your body through exactly the
same chemical processes that caramelize onions or peanut brittle.
math is simple: more sugar equals more AGEd proteins. As a result,
people with diabetes begin to feel the effects of glycation at much
younger ages than do people with more normal blood sugar levels.
Watching people with diabetes age is like watching “normal” aging played
on fast-forward. Slowly, imperceptibly, AGE reactions create chemical
handcuffs, which gum up your proteins, deactivate your enzymes, trigger
unhealthy biochemical signaling in your cells, and damage your DNA.
Make that: AGEing you.
Two Ways to AGE
are two major ways that AGEs can form inside the body. One way is
through a simple series of chemical reactions known as the “Maillard
Pathway,” known from food chemistry for a century. But more recently,
scientists have come to understand another pathway of AGE formation – a
distinctly biological pathway, which only occurs within your cells
because of the body’s metabolism of carbohydrates.
sugar levels rise, some key kinds of cells – including nerve cells
(neurons) and the cells that make up the fine blood vessels of the
retina of the eye and the filtering units (glomeruli) of the kidney –
are also flooded with glucose. The resulting high sugar levels within
these cells cause a logjam in the normal cellular metabolism of glucose.
This backlog results in a buildup within the cell of super-reactive
glucose-metabolic intermediates known as triosephosphates. And once that
happens, the excess triosephosphates attack the surrounding proteins,
lipids, and DNA, causing AGE damage from within the heart of the cell.
These cells are thus the most vulnerable to the complications of
Drugs do exist which can inhibit the formation of AGE,
but none are available on the market as yet, and one of the most
promising candidates (aminoguanidine) has shown signs of toxicity in
human trials and appears to have been abandoned by its developers. On
the other hand, some companies are selling supplements are marketed as
“AGE-inhibitors.” But while many of the herbs and other nutrients may be
valuable, and many even inhibit AGEing in a test tube, there’s no
evidence that most of these “AGE-blocking” ingredients have any effect
on AGEing in your body at the dosages used. Examples include thyme
extract, inositol, acetyl-L-carnitine, taurine, and a whole host of
antioxidants (including n-acetyl-cysteine (NAC) and flavonoids, such as
quercetin and resveratrol).
TPP: Our Hero … in Chains!
is a nutrient that could, in theory, pack a potent wallop against the
AGE onslaught: Thiamin Pyrophosphate (TPP), the active coenzyme form of
the B-complex vitamin thiamin. In 1996, researchers showed that TPP
could step in to stop AGE formation at the most important point in the
process: the late, irreversible conversion of Amadori products into
full-blown AGEs. What’s more, TPP can exert a two-pronged AGE-inhibiting
effect in the body, because boosting TPP in cells stressed by high
glucose concentrations opens up an important biochemical “safety valve”
in the normal metabolism of blood sugar through an enzyme known as
transketolase. Activating transketolase allows the body to shunt excess
triosephosphates into a safe alternative metabolic pathway, preventing
the logjam that leads to the buildup of triosephosphates and the
formation of AGE.
Unfortunately, this does not mean that loading
up on regular thiamin (vitamin B1) will free you from glycation’s sticky
shackles. The problem is that your body’s ability to absorb and
metabolize conventional thiamin supplements is very limited. In fact, no
matter how much thiamin you take, you don’t materially increase plasma
levels beyond what you get from the first 12 milligrams of the dose. And
then getting thiamin into the cells to do its job is just as tricky.
might think that you can get around this problem by taking supplements
containing TPP itself, instead of plain old thiamin. Unfortunately, as
part of the normal cellular absorption process, specific enzymes
actually strip TPP of its phosphate groups. As a result, you get no
additional AGE-battling benefit from taking preformed thiamin
pyrophosphate instead of standard thiamin. In fact, when you take
supplements based on TPP itself, studies show that thiamin levels and
biological activity are actually lower than if you take the same amount
of regular thiamin!
Benfotiamine: the TPP Solution
an effective way to boost thiamin pyrophosphate in your cells does
exist: Benfotiamine (S-benzoylthiamine-O-monophosphate). Benfotiamine is
a derivative of thiamine. Although benfotiamine is not lipid soluble,
it has been shown to have very good bioavailability. This is because
benfotiamine is converted into another compound, called
S-benzoylthiamin, by the enzymes present in the cells of the intestinal
mucosa. S-benzoylthiamine has better fat solubility, and therefore
passes easily through cell membranes. S-benzoylthiamine is then
transported to the liver where it is converted to thiamine and released
into the bloodstream.
As a result, your body absorbs Benfotiamine
better than thiamin itself, and levels of thiamin and also TPP remain
higher for longer. Thiamin absorption from Benfotiamine has been shown
to be about five times as great as from conventional thiamin
have shown that Benfotiamine is even more bioavailable than the other
thiamine-related compounds called allithiamines, including thiamin
tetrahydrofurfuryl disulfide/TTFD. Yet Benfotiamine is actually less
toxic than conventional thiamin supplements. By effectively increasing
levels of thiamin itself, Benfotiamine dramatically boosts AGE-fighting
thiamin pyrophosphate and cell-shielding transketolase activity in your
Shielding Nerve Structure
most “anti-AGE” supplements rely on test-tube “browning” experiments as
the “evidence” of efficacy, Benfotiamine has been proven in multiple
real-world human and animal studies to reduce AGE formation and support
tissue structure and function in diabetics.
many randomized, double-blind, placebo-controlled human trials have
proven that Benfotiamine powerfully supports nerve function in diabetic
neuropathy. In one trial, 24 people suffering with diabetic neuropathy
took either Benfotiamine (plus doses of common B6 and B12 similar to
those used in mutivitamins) or a look-alike dummy pill, spread out into
three pills over the course of the day, for twelve weeks. The
participants started with 320 milligrams of Benfotiamine per day for the
first two weeks, followed by 120 milligrams for the rest of the trial.
Before and after the trial, the function of patients’s nerve cells were
tested using nerve conduction velocity (NCV) and vibratory perception
threshold (which tests the nerves’s sensitivity by determining the
lowest level at which vibrations applied at key nerve sites are first
At the end of the trial, the vibration perception threshold
had “clearly” improved by 30% in those who had taken the Benfotiamine
supplements, while it had worsened in the placebo group by 5% at one
site and by 32% at another. At the same time, people taking Benfotiamine
experienced statistically significant improvements in nerve conduction
velocity from the feet, even as this aspect of nerve function
deteriorated in those taking the look-alike pills!
The power of
Benfotiamine to improve vibratory perception threshold and nerve
conduction velocity have been confirmed in other trials. Clinical trials
have also shown that Benfotiamine supports nerve function in diabetics
as measured by many other methods. For instance, Benfotiamine users
experience a 50% reduction in diabetic nerve pain, along with an
increased ability of the nerves to detect an electrical current, respond
to electrical stimulation, and regulate the heartbeat. Similarly,
Benfotiamine prevents this loss of control from happening in the first
place in diabetic dogs. In another human clinical trial, a B-vitamin
combination using Benfotiamine as its thiamin source was put
head-to-head with a B-complex supplement that included a megadose of
conventional thiamin. Benfotiamine proved its effectiveness on several
of these key parameters, while the standard thiamin pill failed.
benefits are not due to changes in blood sugar levels (either fasting,
or after a meal, or averaged over several months (as measured by HbA1c),
or improvements in metabolic benchmarks. They are the direct results of
Benfotiamine’s AGE-fighting, metabolic-balancing powers.
Benfotiamine in Other Vulnerable Tissues
recently, new studies have begun to document Benfotiamine’s ability to
shield other tissues from AGE damage. One just-published study tested
the ability of thiamin and Benfotiamine to protect diabetic rodents’
retinas from the ravages of AGE.
The researchers then gave one
group of diabetic rodents Benfotiamine supplements, and left another
group unsupplemented, keeping a third group of nondiabetic animals as a
control group. Nine months later, they examined the animals’ eyes,
testing the level of AGE in their retinas, examining metabolic
abnormalities of the cells, and looking for acellular capillaries (the
dead husks left behind when the cells of the tiny blood vessels of the
Benfotiamine supplements normalized AGE levels in the
diabetics’ retina, as well as several key metabolic parameters within
the diabetic animals’ cells – without influencing body weight or blood
sugar (as measured by HbA1c). More importantly, Benfotiamine prevented
the AGE-associated retinal damage. After nine months of diabetes,
diabetic animals had suffered three times as many acellular capillaries
as were found in healthy animals. But with the protection afforded by
Benfotiamine, the number of acellular capillaries in the supplemented
diabetics was indistinguishable from that of their normal, healthy
And there’s another AGE-related disease that researchers
believe Benfotiamine may fight: the loss of kidney function which
accompanies “normal” aging, and which is accelerated by diabetes. Dr.
Paul Thornalley of the University of Essex has just completed a study
designed to see if Benfotiamine will protect diabetic rodents against
kidney damage. While the results have not yet been published, Dr.
Thornalley has indicated that both megadose thiamin and Benfotiamine
caused clear-cut reductions in the leakage of protein – with
Benfotiamine showing itself to be the superior intervention. A second
study is now underway to see if Benfotiamine will actually improve
kidney function in diabetic animals with pre-existing kidney damage, as
it has already been shown to do in the nerves of diabetic animals and
The End of an AGE
These are not
test-tube studies. The results experienced when taking Benfotiamine
occur not merely in labs, but in lives: in the bodies – and in the
health – of living things, from experimental animals to human beings. In
Benfotiamine, we finally have a proven way to protect tissues from the
the rise of diabetes and other health complications related to high
levels of blood sugar, many are searching for antioxidant protection
against the ravaging effects of advanced glycation end products in the
body. Some of the most common supplements used for this purpose include
the B vitamins, antioxidants and herbs that help to lower blood sugar
levels and or protect the body.
was the first to introduce Benfotiamine to North America in 2001.
Benfotiamine is a natural and bioavailable source of vitamin B1 and may
be helpful in reducing the symptoms and complications of diabetes.
Write a useful product review, and get a personal coupon or gift card for your order!
Search by Brand
CAD/USD Exchange Rate