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NPN
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Product Code
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Size
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Weight per Capsule
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Vegetarian
|
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80015791
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AOR05023
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90 Vegi -Caps
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300 mg
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100 % Vegetarian
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AOR Bearlic Garlic SUPPLEMENT FACTS:
Serving Size: 1 Capsule
Other ingredients: none. Capsule: hypromellose, water.
AOR guarantees that
no ingredients not listed on the label have been added to AOR Bearlic Garlic. AOR Bearlic Garlic contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish,
shellfish, or any animal byproducts. Wild garlic is virtually odor-free on the breath.
AOR Bearlic Garlic Suggested Use
Take
one capsule two to three times a day with/without food, or as directed
by a qualified health care practitioner. Consult a health care
practitioner prior to use if you are pregnant, taking blood thinners or
protease inhibitors, or if you have diabetes.
Main applications of AOR Bearlic Garlic
As reported by literature:
• Cardiovascular support.
• Supports healthy blood pressure.
Source of AOR Bearlic Garlic
Allium sativum
AOR Bearlic Garlic During Pregnancy / Nursing
Safe at one capsule a day.
Cautions
• Infants and children should not use the product.
*These
statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any
disease.
Nutrients and Phytochemicals
• Significantly more of many essential nutrients than common kitchen garlic, including such minerals as magnesium, manganese, and zinc.
• Twice the amount of ajoenes, the components of garlic believed to be responsible for garlic's ability to prevent the formation of dangerous blood clots.
• High content of gamma-glutamyl peptides, the
phytochemicals responsible for garlic's ability to inhibit
angiotensin-converting enzyme (ACE) - the target of the so-called "ACE
inhibitor" drugs. Therefore, Allium sativum is a more powerful natural
"ACE inhibitor" than kitchen garlic extracts.
• Twenty-fold higher levels of adenosine. Adenosine
works by opening up the ATP-dependent potassium (KATP) channel in the
smooth muscles of blood vessels, leading them to relax and present less
resistance to the force of the blood flowing through them.
•Various phytochemicals present in Allium sativum protect adenosine from destruction, allowing a significant amount of it to be absorbed intact.
Bearing the Pressure
Kitchen garlic, and extracts
made from it, does appear to have some ability to lower blood pressure,
but the effect is weak and inconsistent - hardly surprising, granted
that supermarket garlic contains so little of the key phytonutrients
which support lower blood pressure. Several studies show that Allium
sativum consistently supports healthy blood pressure, and does a better
job than kitchen-garlic supplements.
In one study, the effects of Allium were tested in animals fed a
hypertension-accelerating diet. The diet caused a dangerous 29% increase
in the activity of the blood pressure elevating ACE enzyme. Along with
it, their blood pressure climbed upward by 8%. Both the increase in ACE
activity, and the rise in BP, suffered by the animals receiving the diet
but no supplements, were not only stopped, but reversed, by Allium.
Hope for Hearts In Crisis
Ventricular fibrillation
- the fatal loss of the heart's rhythm, reducing a regular drumbeat to a
spastic, ineffectual quiver with no power to pump blood - can be the
most dangerous part of a heart attack. Ventricular fibrillation begins
the process that ends in cardiac arrest. And it's fibrillation that is
attacked by defibrillators.
• In one study, rodents were subjected to a simulated heart attack
after being fed either regular lab chow, or a diet supplemented with
Allium for eight weeks. After twenty minutes of heart attack conditions,
88% of the untreated animals' hearts had entered into ventricular
fibrillation, versus only 20% of the hearts of animals that had received
Allium ursinum.
• After the regular flow of blood was restored to the animals'
hearts, every single one of the untreated animals' hearts entered into
ventricular tachycardia, a condition of wildly racing heartbeat which
can lead the heart back into fibrillation; by contrast, 30% fewer
animals whose diets had been supplemented with Allium became
tachycardic.
• Significantly fewer of the Allium-supplemented animals' heart
weight actually became ischemic (starved for oxygen) (33.6% vs 40.9% of
heart weight).
References
i. Beretz A, Cazenave JP. "Old
and new natural products as the source of modern antithrombotic drugs."
Planta Med. 1991 Oct; 57(7): S68-72.
ii. Sendl A, Elbl G, Steinke
B, Redl K, Breu W, Wagner H. "Comparative pharmacological investigations
of Allium ursinum and Allium sativum." Planta Med 1992 Feb; 58(1): 1-7.
iii. Mutsch-Eckner M, Meier B,
Wright AD, Sticher O. "Gamma-glytamyl peptides from allium sativum
bulbs." Phytochemistry. 1992 Jul; 31(7): 2389-91.
iv. Chen CW, Chang HY, Hsiue
TR. "Mechanism of adenosine-induced vasodilation in rat diaphragm
microcirculation." Am J Physiol Heart Circ Physiol. 2000 Nov; 279(5):
H2210-7.
v. Mohamadi A, Jarrell ST, Shi
SJ, Andrawis NS, Myers A, Clouatre D, Preuss HG. "Effects of wild
versus cultivated garlic on blood pressure and other parameters in
hypertensive rats." Heart Dis. 2000 Jan/Feb; 2(1): 3-9.
vi. Preuss HG, Clouatre D,
Mohamadi A, Jarrell ST. "Wild garlic has a greater effect than a
cultivated garlic on blood pressure and blood chemistries of rats." Int
Urol Nephrol. 2001; 32(4): 525-30.
vii.
Rietz B, Isensee H, Strobach H, Makdessi S, Jacob R. "Cardioprotective
actions of wild garlic (allium ursinum) in ischemia and reperfusion."
Mol Cell Biochem. 1993 Feb 17; 119(1-2): 143-50.
Exploring Allium species as a source of potential medicinal agents.
Phytother Res. 2006 Jul;20(7):581-4.
Stajner D, Milic N, Canadanovic-Brunet J, Kapor A, Stajner M, Popovic BM.
It
has been shown that Allium species may help to prevent tumor promotion,
cardiovascular diseases and aging; all processes that are associated
with free radicals. Therefore the Allium species of both cultivated
species (Allium nutans L., Allium fistulosum L., Allium vineale L.,
Allium psekemense B. Fedtsch, Allium cepa L., Allium sativum L.) and
wild species (Allium flavum L., Allium sphaerocephalum L., Allium
atroviolaceum Boiss, Allium schenoprasum L., Allium vineale L., Allium
ursinum L., Allium scorodoprasum L.) from various locations were
investigated for their antioxidative properties. The leaves were
examined for activities of antioxidative enzymes (catalase, peroxidase,
superoxide-dismutase, glutathione-peroxidase), non-enzymic antioxidants
(reduced glutathione and total flavonoids), content of soluble proteins,
vitamin C, carotenoids, chlorophylls a and b, as well as the quantities
of malonyldialdehyde and *OH and O2*- radicals. Using a contemporary
spectroscopic fluorescent method, lipofuscin, 'plant age pigments' were
determined. ESR spectroscopy was used to follow the decrease of oxygen
radicals in the presence of extracts of Allium species in phosphate
buffer (pH 7). The results showed that all Allium species had strong
antioxidative properties due to their high concentration of total
flavonoids, high content of carotenoids and chlorophylls, and very low
concentrations of toxic oxygen radicals. ESR signals of DMPO-OH radical
adducts, in the presence of Allium extracts in phosphate buffer (pH 7),
were reduced by up to 94.3%.
Old and new natural products as the source of modern antithrombotic drugs.
Planta Med 1991 Oct; 57(7): S68-72.
Beretz A, Cazenave JP.
Natural
compounds have been the first historical source of antithrombotic
compounds (heparin, vitamin K antagonists, streptokinase, urokinase);
molecules extracted from plants or animals still provide some of the
most original and promising approaches for the discovery of new drugs in
this class. In this review, we will briefly describe three examples of
current research trends that could lead to the development of new
antithrombotic drugs of natural origin. Flavonoids have been shown to be
inhibitors of cyclic nucleotide phosphodiesterase; this enzymatic
activity is one of the main mechanisms of inhibition of aggregation of
blood platelets by flavonoids. Some of these compounds could represent
templates for the development of new inhibitors of platelet activation.
Garlic (Allium sativum) has been shown to inhibit platelet aggregation
in vivo and in vitro; a number of active principles has now been
identified and their mechanisms of action are currently being explored.
An ancient remedy, the medicinal leech (Hirudo medicinalis), has been
found to contain several potent anticoagulant proteins. Among them,
hirudin, a polypeptide of 65 amino acids, has been identified as one of
the most potent inhibitors of thrombin. The production of sufficient
amounts of hirudin through molecular biology techniques has now allowed
the performance of clinical trials. These three examples show that
careful consideration of biochemical, ethnopharmacological, or
toxicological properties of natural products can still constitute a
valuable basis for the development of new drugs.
Comparative pharmacological investigations of Allium ursinum and Allium sativum.
Planta Med 1992 Feb; 58(1): 1-7.
Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H.
Extracts
of wild garlic (Allium ursinum) and garlic (A. sativum) with defined
chemical compositions were investigated for their in vitro inhibitory
potential on 5-lipoxygenase (LO), cyclooxygenase (CO), thrombocyte
aggregation (TA), and angiotensin I-converting enzyme (ACE). The
inhibition rates as IC50 values of both extracts for 5-LO, CO, and TA
showed a good correlation with the %-content of the major S-containing
compounds (thiosulfinates and ajoenes) of the various extracts. In the
5-LO and CO test the garlic extracts are slightly superior to the wild
garlic extracts whereas, in the TA test, no differences could be found.
In the ACE test the water extract of the leaves of wild garlic
containing glutamyl-peptides showed the highest inhibitory activity
followed by that of the garlic leaf and the bulbs of both drugs. The
comparative studies underline the usefulness of wild garlic as a
substitute of garlic.
Mechanism of adenosine-induced vasodilation in rat diaphragm microcirculation.
Am J Physiol Heart Circ Physiol 2000 Nov; 279(5): H2210-7.
Chen CW, Chang HY, Hsiue TR.
The
mechanism of adenosine-induced vasodilation in rat diaphragm
microcirculation was investigated using laser Doppler flowmetry.
Adenosine (10(-5), 3.2 x 10(-5), and 10(-4) M), the nonselective
adenosine agonist 5'-N-ethylcarboxamido-adenosine (NECA) (10(-8)-10(-7)
M), the specific A(2A) agonist
2-p-(2-carboxyethyl)phenyl-amino-5'-N-ethyl carboxamidoadenosine
(CGS-21680) (10(-8)-10(-7) M), and the adenosine agonist with higher
A(1)-receptor affinity, R-N(6)-phenylisopropyladenosine (R-PIA) (10(-7),
3.2 x 10(-7), and 10(-6) M) elicited a similar degree of incremental
increase of microcirculatory flow in a dose-dependent manner. The
ATP-dependent potassium (K(ATP)) channel blocker glibenclamide (3.2 x
10(-6) M) significantly attenuated the vasodilation effects of these
agonists. Adenosine-induced vasodilation could be significantly
attenuated by the nonselective adenosine antagonist
8-(p-sulfophenyl)-theophylline (3 x 10(-5) M) or the selective A(2A)
antagonist 4-(2-[7-amino-2-(2-furyl)[1,2,
4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl) phenol (ZM-241385,
10(-6) M), but not by the selective A(1) antagonist 8-cyclopentyl-1,
3-dipropylxanthine (5 x 10(-8) M). Adenylate cyclase inhibitor
N-(cis-2-phenyl-cyclopentyl) azacyclotridecan-2-imine-hydrochloride
(MDL-12330A, 10(-5)M) effectively suppressed the vasodilator response of
adenosine and forskolin. These results suggest that adenosine-induced
vasodilation in rat diaphragm microcirculation is mediated through the
stimulation of A(2A) receptors, which are coupled to adenylate cyclase
activation and opening of the K(ATP) channel.
Effects of wild versus cultivated garlic on blood pressure and other parameters in hypertensive rats.
Heart Dis 2000 Jan-Feb; 2(1): 3-9.
Mohamadi A, Jarrell ST, Shi SJ, Andrawis NS, Myers A, Clouatre D, Preuss HG.
Two
separate studies were performed on hypertensive rats to assess the
effects of wild, uncultivated garlic on elevated systolic blood pressure
(SBP) and other cardiovascular parameters. Also, effects of wild garlic
and cultivated garlic preparations were compared and the mechanisms
behind pressure-lowering abilities of different garlic preparations were
examined. The initial study determined that wild garlic lowers blood
pressure. In the second study, cardiovascular effects of three different
concentrations of wild garlic and two different cultivated garlics,
i.e., a preparation low in allicin and one high in allicin, were
compared. All three garlic preparations decreased SBP significantly.
Wild garlic produced the greatest pressure-lowering effects, and the
least pressure-lowering effects were seen with low-allicin garlic.
Compared with control rats, circulating angiotensin II levels were
significantly lower in all garlic-eating rats. Losartan decreased blood
pressure significantly less and Nw-nitro-L arginine-methyl ester
hydrochloride (LNAME) increased blood pressure significantly more in
garlic-eating rats than in control rats, suggesting that the
renin-angiotensin system (RAS) was less active and the nitric oxide
system more active in garlic-consuming hypertensive rats. Accordingly,
different garlic preparations, especially wild garlic, favorably
influenced high SBP in hypertensive rats. These results suggest that
both the RAS and the nitric oxide system are involved in the
antihypertensive effects of garlic in hypertensive rats.
Wild garlic has a greater effect than regular garlic on blood pressure and blood chemistries of rats.
Int Urol Nephrol 2001; 32(4): 525-30.
Preuss HG, Clouatre D, Mohamadi A, Jarrell ST.
When
groups of 10 Spontaneously Hypertensive Rats (SHR) were fed diets
containing either 1% w/w regular garlic (Allium sativum) (AS) or 1% w/w
wild garlic (Allium ursinum) (AU) for 45 days, the final mean systolic
blood pressure (SBP) was reduced significantly compared to control (C)
(C 189; AS 175; Au 173 mm Hg). Compared to C, body weight and
circulating glucose and triglyceride levels were not significantly
different; but circulating insulin was significantly higher (C 23.6; AS
33.9; AU 29.5 uIU/dl), and total cholesterol was significantly lower (C
133; AS 115; AU 117 mg/dl) in the two groups consuming AS or AU. HDL
rose in the two garlic groups, but the differences from C were
statistically significant only for the AU group. In a second study, the
effects of a lower dose of dietary AS and AU (0.1% w/w) on SBP and
various blood chemistries were compared head-to-head in 80 SHR-40
control and 40 test rats. Both AS and AU decreased SBP significantly
compared to a control group of 10 SHR followed simultaneously. However,
AU at this lower concentration produced a significantly greater
SBP-lowering effect compared to the AS group. In addition, AU decreased
total cholesterol significantly and tended to increase HDL compared to
AS. Accordingly, the results suggest that AU has a greater therapeutic
benefit compared to AS at a given concentration.
Cardioprotective actions of wild garlic (allium ursinum) in ischemia and reperfusion.
Mol Cell Biochem 1993 Feb 17; 119(1-2): 143-50.
Rietz B, Isensee H, Strobach H, Makdessi S, Jacob R
The
susceptibility to ventricular arrhythmias under the conditions of
cardiac ischemia and reperfusion was investigated in the Langendorff
heart preparation of rats fed for eight weeks a standard chow enriched
with 2% of pulverized wild garlic leaves. The isolated hearts were
perfused with a modified Krebs-Henseleit solution. The incidence of
ventricular fibrillation (VF) during 20 min occlusion of the descending
branch of the left coronary artery (LAD) was significantly reduced in
the wild garlic group as compared to untreated controls (20% vs 88%).
The same holds for the size of the ischemic zone (33.6% vs 40.9% of
heart weight). In the reperfusion experiments (5 min after 10 min
ischemia), ventricular tachycardia (VT) occurred in 70% of the wild
garlic group vs 100% in untreated controls and VF in 50% vs 90%. The
time until occurrence of extrasystoles, VT or VR was prolonged. No
significant alterations in cardiac fatty acid composition could be
observed. Although the prostacyclin production was slightly increased in
hearts of the wild garlic group, inhibition of cyclooxygenase by
acetylsalicylic acid (ASA; aspirin) could not completely prevent the
cardioprotective effects suggesting that the prostaglandin system does
not play a decisive role in the cardioprotective action of wild garlic.
Furthermore, a moderate angiotensin converting enzyme (ACE) inhibiting
action of wild garlic was found in vitro as well as in vivo that could
contribute to the cardioprotective and blood pressure lowering action of
wild garlic. Whether a free radical scavenging activity of wild garlic
is involved in its cardioprotective effects remains to be established.
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