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AOR, Advanced Joint Support, 90 vcaps - AOR Advanced Joint Support is a combination of herbs and other ingredients for the relief of joint pain associated with osteoarthritis and inflammation.
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AOR, Advanced Joint Support, 90 vcaps

AOR Advanced Joint Support - 60 caps
Advanced Joint Support - 60 caps, aor vitamins supplements
AOR, Advanced Joint Support, 90 vcaps is manufactured by AOR Supplements

Last updated on 12/5/2016
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Advanced Joint Support

  • New & improved formula – now more HA
  • Relieves join pain, inflammation and stiffness
  • Prevents the breakdown of joint cartilage
  • Improves joint function and mobility
Advanced Joint Support helps relieve pain and swelling associated with osteoarthritis of the knee.
NPN Product Code Size Per Capsule Vegetarian
80033425 AOR04179 90 Vegi-Caps 443 mg Vegetarian
Supplement Facts
Serving Size: 1 Capsule
Amount Per Capsule

Boswellia serrata (40% boswellic acids) 333 mg
Sodium Hyaluronate 40 mg
Harpagophytum procumbens (Devil’s Claw 20-25:1 extract)  70 mg

Non-medicinal ingredients: potato starch. Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, peanuts, sesame seeds, mustard, dairy, eggs, fish, shellfish or any animal byproducts.

Adult Dosage: Take 1 capsule three times daily with food, or as directed by a qualified health care practitioner. Use for a minimum of 6 weeks to see beneficial effects.

Cautions: Consult a health care practitioner for use for beyond 2 months or if symptoms persist or worsen. Some people may experience mild gastrointestinal effects such as diarrhea, abdominal pain/cramps and nausea. Hypersensitivity (e.g. allergy) has been known to occur, in which case, discontinue use.

Pregnancy/Nursing: Do not use

Source:
Boswellia serrata and Devil's Claw - natural botanical extracts
Hyaluronic acid - biofermentation, now wheat & corn-free

Main Indications:

  • Osteoarthritis
  • Inflammation
  • Joint Pain and Stiffness

Research

Background Information

Understanding Osteoarthritis
Osteoarthritis is a debilitating disease of the joints that affects a huge proportion of the population.  Up to 85% of people over the age of 70 and 20% of the general population are affected by this painful disease. Healthy joints are protected and cushioned by layers of connective tissue called cartilage that allows them to move freely without any grinding or contact between the bone surfaces themselves.  A special fluid in the joint capsule, called synovial fluid, is also extremely important for joint function. It acts as a natural lubricant and cushions joint movement. In patients with osteoarthritis there is a reduction in synovial fluid and a loss of cartilage that eventually leads to cartilage degeneration. This results in severe joint pain, inflammation, stiffness and an eventual loss of mobility.

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The most common treatment for osteoarthritis involves anti-inflammatory drugs that treat the symptoms, but do not target the root cause of arthritis. These drugs are also associated with a large number of unpleasant and potentially serious side-effects and adverse reactions involving the gastrointestinal system, the skin, the nervous system, liver, kidneys and bone marrow.  AOR’s Advanced Joint Support is a formula containing a combination of natural herbs and compounds that work together to reduce the symptoms of arthritis and to improve joint function without the side effects of pharmaceutical drugs.

Hyaluronic Acid
Hyaluronic acid is an essential component of the synovial fluid, which is required for proper joint lubrication and function. It also has anti-inflammatory effects.  Patients with osteoarthritis have been shown to have reduced hyaluronic acid content in their joints.  Normal synovial fluid contains 3-4 mg/ml of hyaluronic acid. Hyaluronic acid helps protect joints by augmenting the viscosity of the synovial fluid, by increasing the elasticity of the cartilage found in joints and because of its anti-inflammatory effect. Supplementation with hyaluronic acid reduces pain and improves function in patients with osteoarthritis of the knee. These effects are thought to be attributable to the return of a more normal synovial fluid, improved viscoelasticity, improved cartilage biosynthesis, anti-inflammatory and analgesic effects.

Boswellia serrata
Extracts of the plant Boswellia serrata have been noted for their anti-inflammatory, anti-arthritic and analgesic properties. Boswellia extracts have even been shown to be more effective than the anti-inflammatory drug valdecoxib for improving arthritis symptoms over a six month period. Furthermore, unlike anti-inflammatory drugs, the positive effects of Boswellia persist even after intake of the herb is stopped. This suggests that Boswellia may be targeting the source of osteoarthritis, not just controlling the symptoms.

Devil’s Claw
Extracts from the African plant Devil’s Claw contain harpogasides – active compounds with potent anti-inflammatory, analgesic and anti-arthritic actions. Clinical trials with devil’s claw have had very promising results.  Devil’s claw has been shown to significantly reduce the pain and stiffness associated with arthritis.  It reduces inflammation, helps promote cartilage regeneration and increases the production of hyaluronic acid. In one study, 171 out of 222 patients taking devil’s claw reported a beneficial effect, and showed significant improvements in pain, function and stiffness scores.

Mechanisms of Action
The ingredients contained in Advanced Joint Support work via a variety of mechanisms to improve the symptoms and debilitating effects associated with osteoarthritis.  Devil’s claw and Boswellia serrata act to decrease inflammation by blocking key enzymes, like cyclo-oxygenase-2 (COX-2) and lipoxygenase that are involved in stimulating the inflammatory process. They also act to suppress certain pro-inflammatory signaling and molecules like leukotrienes. Boswellia serrata and devil’s claw have an even broader mechanism of action, inhibiting signaling molecules and enzymes that break down collagen and proteins called glucosaminoglycans (GAGs). Collagen and GAGs are both critical components of cartilage. Devil’s claw has even been shown to increase GAG synthesis, promoting the formation of new cartilage.

Research

In an open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib (a Cox-2 Inhibitor) in patients with osteoarthritis of the knee it was found that in those taking the boswellia, the pain, stiffness, difficulty in performing daily activities showed statistically significant improvement with two months of therapy which even lasted till one month after stopping the intervention. Those taking Boswellia showed a slower onset of action but the effect persisted even after stopping therapy while the action of valdecoxib became evident faster but waned rapidly after stopping the treatment.

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In a study on the effectiveness and safety of Devil’s Claw taken by patients with general rheumatic disorders it was demonstrated that there were statistically significant improvements in patient assessment of global pain, stiffness and function. There were also statistically significant reductions in mean pain scores for hand, wrist, elbow, shoulder, hip, knee and back pain. Quality of life measurements were also significantly increased and 60% patients either reduced or stopped concomitant pain medication. Devil’s Claw is an effective and well-tolerated serious treatment option for mild to moderate degenerative rheumatic disorders providing improved quality of life measure.

Market Trends

Since a large portion of the aging population is dealing with joint discomfort, it is common to turn to serious medications in order to manage pain. Unfortunately, some of these medications have adverse and serious side effects. AOR’s Advanced Joint Support is a formula containing a combination of natural herbs and compounds that work together to reduce the symptoms of arthritis and to improve joint function without the side effects of pharmaceutical drugs. 

AOR Advantage

AOR’s Advanced Joint Support is a formula containing a combination of natural herbs and compounds that work together to reduce the symptoms of arthritis and to improve joint function without the side effects of pharmaceutical drugs. 

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