AOR guarantees that no ingredients not listed on the label have been added to AOR Advanced Joint Support. AOR Advanced Joint Support contains no nuts, dairy, soy, eggs, fish, shellfish or any animal byproduct..

Suggested Use 
Take one capsule twice daily with food, or as directed by a qualified health care practitioner.  Do not take AOR Advanced Joint Support if pregnant or nursing.

Main Applications
- Osteoarthritis
- Inflammation
- Joint Pain and Stiffness

Source
Multi-Sourced

Cautions
None Known

The most common treatment for osteoarthritis involves anti-inflammatory drugs that treat the symptoms, but do not target the root cause of arthritis. These drugs are also associated with a large number of unpleasant and potentially serious side-effects and adverse reactions involving the gastrointestinal system, the skin, the nervous system, liver, kidneys and bone marrow.  AOR Advanced Joint Support is a formula containing a combination of natural herbs and compounds that work together to reduce the symptoms of arthritis and to improve joint function without the side effects of pharmaceutical drugs. 

Hyaluronic Acid

Hyaluronic acid is an essential component of the synovial fluid, which is required for proper joint lubrication and function. It also has anti-inflammatory effects.  Patients with osteoarthritis have been shown to have reduced hyaluronic acid content in their joints.  Normal synovial fluid contains 3-4 mg/ml of hyaluronic acid. Hyaluronic acid helps protect joints by augmenting the viscosity of the synovial fluid, by increasing the elasticity of the cartilage found in joints and because of its anti-inflammatory effect. Supplementation with hyaluronic acid reduces pain and improves function in patients with osteoarthritis of the knee. These effects are thought to be attributable to the return of a more normal synovial fluid, improved viscoelasticity, improved cartilage biosynthesis, anti-inflammatory and analgesic effects.

Boswellia serrata

Extracts of the plant Boswellia serrata have been noted for their anti-inflammatory, anti-arthritic and analgesic properties.  Boswellia extracts have even been shown to be more effective than the anti-inflammatory drug valdecoxib for improving arthritis symptoms over a six month period.  Furthermore, unlike anti-inflammatory drugs, the positive effects of Boswellia persist even after intake of the herb is stopped. This suggests that Boswellia may be targeting the source of osteoarthritis, not just controlling the symptoms.

Devil’s Claw

Extracts from the African plant Devil’s Claw contain harpogasides – active compounds with potent anti-inflammatory, analgesic and anti-arthritic actions. Clinical trials with devil’s claw have had very promising results.  Devil’s claw has been shown to significantly reduce the pain and stiffness associated with arthritis.  It reduces inflammation, helps promote cartilage regeneration and increases the production of hyaluronic acid. In one study, 171 out of 222 patients taking devil’s claw reported a beneficial effect, and showed significant improvements in pain, function and stiffness scores.

Mechanisms of Action
The ingredients contained in Advanced Joint Support work via a variety of mechanisms to improve the symptoms and debilitating effects associated with osteoarthritis.  Devil’s claw and Boswellia serrataact to decrease inflammation by blocking key enzymes, like cyclo-oxygenase-2 (COX-2) and lipoxygenase that are involved in stimulating the inflammatory process. They also act to suppress certain pro-inflammatory signaling and molecules like leukotrienes. Boswellia serrata and devil’s claw have an even broader mechanism of action, inhibiting signaling molecules and enzymes that break down collagen and proteins called glucosaminoglycans (GAGs). Collagen and GAGs are both critical components of cartilage. Devil’s claw has even been shown to increase GAG synthesis, promoting the formation of new cartilage.