New Chapter's patented Zyflamend formulation represents a scientific breakthrough in promoting a healthy inflammation response. Recent research studies suggest this may be an effective strategy to promote healthy joint function and normal cell growth.

New Chapter’s Supercritical Herbal Extracts

“Supercritical” means Super Purity, Super Potency, Broad Spectrum, and No Chemical Solvents. We take nature’s finest herbs and then extract and highly concentrate (as high as 250 to 1) their precious ingredients. We do not isolate out single ingredients or spike our extracts with synthesized additives. We deliver the wisdom of nature with the complexity and organic nuances of the natural herb preserved for you. In fact, the supercritical process is the gentlest way to extract these delicate plant compounds in a manner to optimally preserve their potency and stability. And when you take New Chapter’s supercritical extracts, neither you, nor the environment, have to contend with chemical solvents.

New Chapter has extensively researched the herbal pharmacopoeia and international medical databases and discovered that the following time- tested herbs, properly extracted and blended in the correct proportions, contain a significant number of phytonutrients that may safely and significantly promote a healthy inflammation response.

Zyflamend is not a drug product that is intended as an alternative to prescription anti-inflammatories. Zyflamend is an amalgam comprised of 10 different herbal extracts (Rosemary, Turmeric, Ginger, Holy Basil, Green Tea, Hu Zhang, Chinese Goldthread, Barberry, Oregano, and Scutellaria baicalensis) and was originally chosen based upon their purported anti-inflammatory effects. Recent observations from a variety of both basic and clinical researchers suggest that inflammation and cancer may be intimately related. Columbia University studies have demonstrated that this preparation does, indeed, inhibit major enzymes involved in initiating an inflammatory response (COX-1 and COX-2). Columbia University have also shown that Zyflamend prostate tumor cell growth inhibitor and induces cell death by a process known as apoptosis. To understand the mechanisms through which Zyflamend is acting to suppress prostate cancer cells, Columbia University have continued our studies and have identified several key molecules in which Zyflamend appears to be acting upon. Columbia University have published our initial studies in an esteemed, peer reviewed journal, Nutrition and Cancer (Lawrence Erlbaum Associates, Mahwah, NJ) and Columbia University is currently preparing to present our latest results at the Society for Integrative Oncology’s annual meeting, November 9-11, 2006.

Holy Basil: Contains ursolic acid, which significantly enhances detoxification and promotes a healthy inflammation response.
Turmeric: Unique curcumin phytonutrient complex, synergistic with green tea, significantly multiplying each herb’s ability to promote healthy eicosanoid balance.
Ginger: Supercritical extract modulates both eicosanoid cascades and offers numerous anti-aging constituents.
Green Tea: Proceedings of the National Academy of Sciences report green tea polyphenols exert a beneficial effect on healthy eicosanoid balance. Major university database notes green tea contains 51 phytonutrients that promote a healthy inflammation response.
Rosemary: Dual extracts offer highly concentrated, full spectrum eicosanoid balance and support detoxification.
Hu Zhang: Richest known resveratrol source, with each daily serving delivering the approximate equivalent of six glasses of resveratrol-rich wine.
Chinese Goldthread and Barberry: Unique berberine phytonutrient complex, naturally promotes a healthy inflammation response.
Oregano: Source of large number of phytonutrient modulators (31) according to USDA database.
Baikal Skullcap: Unique baicalin phytonutrient complex, naturally promotes healthy inflammation response.

Zyflamend Reviews

Dr. Mark Joseph, D.C.
“As a Chiropractor, my goal is to balance the spine and relieve nerve interference. To modulate inflammation, Zyflamend is my product of choice. The positive response has been overwhelming. You know you have a great product when patients come back asking for more.”

Robert A. Newman, Ph.D. - Professor of Medicine and Pharmacology
Director, Pharmaceutical Development Center, University of Texas M.D. Anderson Cancer Center
“It is our belief that a combination of plant-based products obtained through a unique extraction process may provide a product where multiple components interact synergistically at relatively low doses. We think that this is a strategy for control of inflammation that may be more appropriate and perhaps even safer compared to the single targeted high dose pharmaceutical agent.”

David Radford, D.C.
“As an adjunct to my therapy, I have recommended Zyflamend to hundreds of patients and found it helpful in promoting a healthy inflammation response. Our profession and other doctors interested in integrative therapies should encourage the use of herbal inflammation modulation, which has been an important part of natural and traditional medical systems for thousands of years.”

Earl Surwit, M.D. Tucson, AZ
“I am a physician and surgeon, specializing for over twenty-five years in gynecologic oncology, and am now practicing urogynecology… I was also the principal investigator of a human clinical trial using a Zyflamend-based protocol with women undergoing chemotherapy treatment for recurrent ovarian cancer. ...We determined that the Zyflamend protocol significantly enhanced the quality of life of the patients in the trial, and on the basis of that trial and my clinical experience, I think Zyflamend holds great promise as an adjuvant therapy for cancer patients undergoing conventional treatment. I also recommend Zyflamend for my patients to support a healthy inflammation response.”

Aaron E. Katz M.D. - Director, Columbia University’s Center for Holistic Urology
“As the Director of Columbia University’s Center for Holistic Urology, I have recommended that my patients take Zyflamend to promote normal prostate functioning. Zyflamend has shown great promise in our urology lab as a highly active herbal formulation, and it has properties that may uniquely promote normal cellular activity in the prostate. My patients and I are pleased with the results obtained with Zyflamend, and I recommend it to doctors and patients alike.”

James P. Nicolai, M.D. - Medical Director Franciscan Center for Integrative Health
"As a practitioner of Integrative Medicine, I am always looking to use natural and safe interventions whenever possible. Science is beginning to show that a healthy inflammation response is important to the immune and cardiovascular systems, mental health, and virtually every other indicator of quality of life and longevity. I’ve found Zyflamend by New Chapter to be the perfect supplement for my patients whenever inflammation support is required.”

Dave Foreman, R.Ph., N.D. - Host of the Natural Pharmacist, author of the forthcoming The Herbal Pharmacist’s Guide to Natural Cancer Therapies
“As an integrative pharmacist with expertise in herbal preparations, I believe that “best practices” in modern medicine should include the use of well-studied and safe herbal formulations that promote health and the quality of life. One such excellent preparation is Zyflamend, with strongly documented ability to support healthy inflammatory processes. My patients and I have enthusiastically embraced Zyflamend and the herbs in that formula have been shown to also promote normal cardiovascular and joint function. It is an important part of my integrative practice.”

Roberta Lee, M.D., Medical Director, Continuum Center for Health and Healing
“As Medical Director of an integrative health center, I use Zyflamend in my practice to promote a healthy inflammation response. I have observed great benefit in patients with a wide range of needs, and I encourage the integrative use of this broad-spectrum herbal formulation.”

Dr. Eliot W. Edwards, N.D. - Center for Integrative Health and Healing, Delmar, NY
“The majority of my patients can value a supplement that supports a healthy inflammation response. I use Zyflamend as part of my treatment plan and I have seen great results restoring normal, healthy function to the prostate, gastrointestinal tract and musculoskeletal system.”

More information about Zyflamend:

Zyflamend & Cancer.
Zyflamend Reviews.
Zyflamend Drug Interactions. Product web site. http://www.new-chapter.com . Accessed March 17, 2011.
Capodice JL, et al. ZyflamendTM, a unique preparation inhibits arachidonic acid metabolism and suppresses prostate cancer cells, in vitro. Abstract presented at the 1st International Conference of the Society for Integrative Oncology, Nov 18, 2004.
Food and Drug Administration.
http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/
EnforcementActivitiesbyFDA/CyberLetters/ucm059203.pdf.
Accessed March 17, 2011.
Bemis DL, et al. Zyflamend , a unique herbal preparation with non selective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression.Nutrition and Cancer 2005; 52(2): 202-12.
Yang P, Sun Z, Chan D, et al. Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model.Carcinogenesis. 2008 Nov;29(11):2182-9.
Sandur SK, Ahn KS, Ichikawa H, et al. Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products.Nutr Cancer. 2007;57(1):78-87.
Capodice JL, Gorroochurn P, Cammack AS, et al. Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial.J Soc Integr Oncol. 2009 Spring;7(2):43-51.
Yang P, Cartwright C, Chan D, et al. Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation.Cancer Biol Ther. 2007 Feb;6(2):228-36.

What is Inflammation?

Many people think that only joints are affected by inflammation. The truth is that the body’s natural inflammatory response affects everyone and every major organ system. Given the link between a healthy inflammation response and whole body health – a source of extensive and ongoing research – a supplement strategy geared toward promoting a healthy inflammation response is as fundamental as a daily multivitamin.* Research at leading medical institutions, including human clinical trials, has demonstrated a unique patented herbal formulation’s ability to promote a safe, natural and healthy response to inflammation.

What is Zyflamend?

Zyflamend contains combinations of herbs used traditionally to promote a healthy inflammation response.
Many of these herbs have been part of human diet for thousands of years. Zyflamend is the #1-selling herbal in the U.S.‡ for healthy inflammation response.
It contains hundreds of bioactive constituents from ten of the most researched botanicals that promote a healthy inflammatory response and provide multiple health benefits: healthy aging, joint health, heart health, and bone health.

Zyflamend

Extensively Researched, Compelling Results New Chapter’s unique patented herbal formula, Zyflamend, represents a scientific breakthrough in the maintenance of a healthy inflammation response.* Recent research studies suggest daily Zyflamend supplementation may be an effective strategy to modulate inflammation and promote healthy joint and prostate function, normal cell growth, and healthy heart unction.* Zyflamend is the subject of ongoing research at preeminent research centers in the United States.

Many people think that only joints are affected by inflammation. The truth is the body’s natural inflammatory response affects everyone and every major organ system. Given the link between a healthy inflammation response and whole body health – a source of extensive and ongoing research – a supplement strategy geared toward promoting a healthy inflammation response is as fundamental as a daily multivitamin.

Multiple Synergistic Components, Whole Body Benefits Health experts agree that a daily multivitamin containing the full spectrum of required vitamins and minerals provides an important “insurance policy”
against nutrient deficiencies and the metabolic imbalances associated with them. Extensive research conducted within the last two decades has indicated that phytochemicals present in herbs and spices can safely and effectively promote a healthy inflammation response.* Combining an herbal protocol with a multivitamin offers the optimal broad-spectrum approach to nutritional and natural inflammation support.*

Research at leading medical institutions, including human clinical trials, has demonstrated a unique herbal formulation’s ability to promote a safe, natural and healthy response to inflammation. Zyflamend contains combinations of herbs used traditionally to promote a healthy inflammation response.* These herbs – most of which have been part of human diet for thousands of years – are uniquely extracted to deliver the full spectrum of naturally occurring constituents.

Zyflamend is the #1-selling herbal in the U.S.‡ for healthy inflammation response.* It contains hundreds of bioactive constituents from ten of the most researched botanicals that promote a healthy inflammatory response and provide multiple health benefits: healthy aging, joint health, heart health, and bone health.* Zyflamend for Healthy Aging “It has been said that the day that one stops fighting
inflammation is the day that you start accelerating the aging process.” Aging is not the simple result of the passage of time. According to a provocative new view, it is actually something our own bodies create, a side effect of the essential inflammatory system. While there is no “cure” for the natural process of aging, the conscious and active control of low-level “silent” inflammation is now believed to have the potential to slow down the natural aging process. Because inflammation is a multi-faceted human process, it is important that we respond to it through a combination of daily “down-regulating” actions… utilizing aspects of our daily diet, regular exercise, and natural bioactives shown to contain inflammation sensitive properties.

Zyflamend for Joint Health

Modulation of the inflammatory process is an important and useful strategy for maintaining healthy joint function.* A healthy inflammatory response may also contribute to a control of adverse bone changes that can cause discomfort and compromise the integrity of the joint. When the inflammatory response is out of balance, joint health may be complicated, in most cases, with bone and soft tissue breakdown of the joint. Glucosamine is used by the body to form and repair cartilage that cushions and protects the body’s joints. A comprehensive approach to joint health demands the presence of building blocks for new cartilage (glucosamine) and a healthy inflammation response.* Zyflamend for Heart Health Recent research suggests that the key factor in predicting heart health is gauging the amount of inflammation in the arteries. C-reactive protein is a blood marker used to assess inflammation and heart health. Early data from a human clinical trial conducted at Columbia University suggests that daily supplementation with Zyflamend promotes healthy levels of C-reactive protein.

In data presented at the 2008 meeting for the Society for Integrative Oncology, researchers reported the following analysis of data from a Zyflamend human clinical: “A statistically significant reduction in serum C-reactive protein was…observed after 18 months.” Maintaining a healthy cardiovascular system is strongly linked to a healthy inflammation response – Zyflamend is the first choice for promoting heart health.

Zyflamend for Bone Health

Emerging evidence suggests that inflammation exerts a significant effect on bone metabolism by stimulating production of RANKL (Receptor Activator for Nuclear Factor κ B Ligand), a molecule which activates osteoclasts, the cells responsible for the breakdown of bone.

An ideal bone health protocol would pair the necessary building blocks for bone remodeling – bioavailable whole-food calcium, magnesium, trace minerals, Vitamins D3 and K2 (MK-7) – with a formula that promotes a healthy and natural inflammation response.

Zyflamend was featured on The Dr. Oz show

Zyflamend, the herbal multi, coupled with Bone Strength Take Care, a whole food source of these key bone building nutrients, is the comprehensive approach to total bone health.

Zyflamend was featured on The Dr. Oz show ...and prominently so!

A full minute and 30 seconds is dedicated entirely on the benefits of Zyflamend in a discussion between Dr. Oz and his guest, Russel Greenfield, MD, Clinical Assistant Professor at UNC Chapel Hill. They referred to Zyflamend as a "miracle solution"!

Here is the link to the clip: http://www.doctoroz.com/videos/supplements-natural-pain-relief