CurcuMIND provides antioxidants and Vitamin D for the maintenance of good health. Curcumind is the most potent AOR
Curcumin formula.
| NPN
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Product Code
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Size
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Per Capsule
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| 80024708
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AOR04259
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90 Vegi-Caps
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133 mg
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| Supplement Facts
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| Serving Size: 3 Capsules
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Amount Per Serving
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|
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| Curcumin (from Longvida® Optimized Curcumin)
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400 mg
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| Vitamin D3
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333 IU/8.33 mcg
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Non-medicinal
ingredients: ascorbyl palmitate, microcrystalline cellulose, soy
lecithin, stearic acid, maltodextrin, and silicon dioxide. Capsule;
hypromellose, water.
LONGVIDA® is a registered trademark of/ Verdure Sciences Inc. International patent pending.
|
AOR guarantees that
no ingredients not listed on the label have been added to CurcuMIND.
CurcuMIND contains no wheat, gluten, nuts, eggs, dairy, fish or shellfish.
Suggested Use:
Take three capsules three times daily, or as directed by a qualified health care practitioner.
Cautions:
Consult
a health care practitioner prior to use if you are pregnant, taking
antiplatelet medication or blood thinners, have gallstones or a bile
duct obstruction, have stomach ulcers or excess stomach acid. Consult a
health care practitioner if symptoms persist or worsen.
Pregnancy/Nursing:
Consult a health care practitioner prior to use.
Main Applications:
The main problem with curcumin has always been its
bioavailability. It is very poorly absorbed into the bloodstream,
meaning that very high doses are required to achieve a noticeable
effect. A key change came when scientists at UCLA began to examine this
problem from a different perspective. Essentially, it is not about how
much curcumin is consumed, it is about how much curcumin is absorbed
into the bloodstream. Eventually this line of research led to a
breakthrough.
CurcuMIND is not your typical curcumin supplements.
These products offer a cutting edge type of curcumin called
Longvida
Optimized Curcumin†. This breakthrough curcumin technology was developed
by scientists at UCLA to dramatically increase the bioavailability and
absorption of curcumin. Human studies have shown that this technology
increases the absorption of curcumin by at least 12 times when compared
with typical 95% curcumin extracts.
This breakthrough technology is the result of ten years of
extensive research. It involves the incorporation of curcumin into a
solid-lipid particle matrix. The premise behind this strategy is that
curcumin is more soluble in fats and oils than in water. By using a
solid-lipid particle scientists were able to increase curcumin’s
bioavailability. But this technology goes well beyond simply dissolving
curcumin in an oil-based delivery system. The particle matrix protects
the curcumin from the harsh stomach environment, and has been clinically
shown to enhance the absorption of curcumin.
CurcuMIND –
A Superior Anti-inflammatory
This
product offers 1200mg of curcumin with 1000IU of vitamin D per daily
dose (9 capsules). This super-high dose of curcumin is designed to
provide support for severe conditions like auto-immune diseases and
Alzheimer’s Disease. It is important that the dose of curcumin in these
products not be compared with those you see in conventional curcumin
supplements. While the dose of 400mg per capsule dose in CurcuMIND may
not initially seem very high, remember that it is not about the dose,
but about how much is absorbed. The optimized curcumin used in these
products has been shown to be at least 100 times more absorbable than
regular curcumin supplements.
This superior bioavailability means that CurcuMIND provides the equivalent of over 13g of curcumin per capsule!
The Power of Curcumin + Vitamin D
AOR
is the first company to offer
Curcumin with vitamin D in a single
product. This combination brings together two highly beneficial
nutrients whose synergistic effects are not only advantageous for the
promotion of good health in general, but which also have amazing
potential for the treatment of a variety of health conditions.
Many
conditions for which curcumin is helpful, such as inflammatory
disorders and auto-immune diseases like IBD, have also been shown to
benefit from
Vitamin D supplementation. Recent research has brought the
importance of
Vitamin D to the forefront by showcasing its role in
preventing a wide variety of health issues. Deficiencies in this vitamin
have now been linked to auto-immune diseases, infections and cognitive
decline. These connections make it an ideal partner for curcumin, which
has been shown to provide support for these same issues.
Furthermore,
new studies are showing amazing promise for curcumin combined with
Vitamin D in the treatment of
Alzheimer’s Disease. This combination has
been shown to help reduce amyloid plaque (a key factor in the
development of Alzheimer’s disease) in the brain. In fact, in animal
experiments,
Longvida Curcumin was found to increase amyloid plaque
clearance from the brain better than four of the top pharmaceutical
drugs for
Alzheimer’s Disease, all in just four days!
†
Longvida is a registered trademark of Verdure Sciences Inc. International patent pending.
REVIEW: Curcumin and Alzheimer’s Disease
Hamaguchi T et al. CNS Neuroscience and Therapeutics. 2010; 16(5): 285-297.
Curcumin
has a long history of use as a traditional remedy and food in Asia.
Many studies have reported that curcumin has various beneficial
properties, such as antioxidant, antiinflammatory, and antitumor.
Because of the reported effects of curcumin on tumors, many clinical
trials have been performed to elucidate curcumin\'s effects on cancers.
Recent reports have suggested therapeutic potential of curcumin in the
pathophysiology of Alzheimer’s Disease (AD). In in vitro
studies, curcumin has been reported to inhibit amyloid-β-protein (Aβ)
aggregation, and Aβ-induced inflammation, as well as the activities of
β-secretase and acetylcholinesterase. In in vivo studies, oral
administration of curcumin has resulted in the inhibition of Aβ
deposition, Aβ oligomerization, and tau phosphorylation in the brains of
AD animal models, and improvements in behavioral impairment in animal
models. These findings suggest that Curcumin might be one of the most
promising compounds for the development of AD therapies. At present,
four clinical trials concerning the effects of curcumin on AD has been
conducted. Two of them that were performed in China and USA have been
reported no significant differences in changes in cognitive function
between placebo and curcumin groups, and no results have been reported
from two other clinical studies. Additional trials are necessary to
determine the clinical usefulness of curcumin in the prevention and
treatment of AD.
Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers.
Gota VS et al. J Agric Food Chem. 2010; 58(4): 2095-2099.
Curcumin is the lipid-soluble antioxidant compound obtained from the rhizome of Curcuma Longa
Linn, also known as turmeric. Curcumin targets multiple
chemotherapeutic and inflammatory pathways and has demonstrated safety
and tolerability in humans, supporting its potential as a therapeutic
agent; however, the clinical literature lacks conclusive evidence
supporting its use as a therapeutic agent due to its low bioavailability
in humans. The purpose of this study was to quantify plasma levels of
free curcumin after dosing of a solid lipid curcumin particle (SLCP)
formulation versus unformulated curcumin in healthy volunteers and to
determine its tolerability and dose−plasma concentration relationship in
late-stage osteosarcoma patients. Doses of 2, 3, and 4 g of SLCP were
evaluated in 11 patients with osteosarcoma. Plasma curcumin levels were
measured using a validated high-performance liquid chromatography
method. The limit of detection of the assay was 1 ng/mL of curcumin. In
healthy subjects, the mean peak concentration of curcumin achieved from
dosing 650 mg of SLCP was 22.43 ng/mL, whereas plasma curcumin from
dosing an equal quantity of unformulated 95% curcuminoids extract was
not detected. In both healthy individuals and osteosarcoma patients,
high interindividual variability in pharmacokinetics and nonlinear dose
dependency was observed, suggesting potentially complex absorption
kinetics. Overall, good tolerability was noted in both healthy and
osteosarcoma groups.
Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention.
Haussler MR et al. Nutrition Reviews. 2008; 68: S98-S112.
The
human vitamin D receptor (VDR) is a key nuclear receptor that binds
nutritionally derived ligands and exerts bioeffects that contribute to
bone mineral homeostasis, detoxification of exogenous and endogenous
compounds, cancer prevention, and mammalian hair cycling. Liganded VDR
modulates gene expression via heterodimerization with the retinoid X
receptor and recruitment of coactivators or corepressors. VDR interacts
with the corepressor hairless (Hr) to control hair cycling, an action
independent of the endocrine VDR ligand, 1,25-dihydroxyvitamin D3.
We report novel dietary ligands for VDR including curcumin,
γ-tocotrienol, and essential fatty acid derivatives that likely play a
role in the bioactions of VDR.
Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease.
Begum AN et al. J Pharmacol Exp Ther. 2008 Jul;326(1):196-208
Curcumin
can reduce inflammation and neurodegeneration, but its chemical
instability and metabolism raise concerns, including whether the more
stable metabolite tetrahydrocurcumin (TC) may mediate efficacy. We
examined the antioxidant, anti-inflammatory, or anti-amyloidogenic
effects of dietary Curcumin and TC, either administered chronically to
aged Tg2576 APPsw mice or acutely to lipopolysaccharide
(LPS)-injected wild-type mice. Despite dramatically higher drug plasma
levels after TC compared with curcumin gavage, resulting brain levels of
parent compounds were similar, correlating with reduction in
LPS-stimulated inducible nitric-oxide synthase, nitrotyrosine, F2
isoprostanes, and carbonyls. In both the acute (LPS) and chronic
inflammation (Tg2576), TC and curcumin similarly reduced interleukin-1β.
Despite these similarities, only curcumin was effective in reducing
amyloid plaque burden, insoluble β-amyloid peptide (Aβ), and carbonyls.
TC had no impact on plaques or insoluble Aβ, but both reduced
Tris-buffered saline-soluble Aβ and phospho-c-Jun NH2-terminal
kinase (JNK). Curcumin but not TC prevented Aβ aggregation. The TC
metabolite was detected in brain and plasma from mice chronically fed
the parent compound. These data indicate that the dienone bridge present
in curcumin, but not in TC, is necessary to reduce plaque deposition
and protein oxidation in an Alzheimer\'s model. Nevertheless, TC did
reduce neuroinflammation and soluble Aβ, effects that may be
attributable to limiting JNK-mediated transcription. Because of its
favorable safety profile and the involvement of misfolded proteins,
oxidative damage, and inflammation in multiple chronic degenerative
diseases, these data relating curcumin dosing to the blood and tissue
levels required for efficacy should help translation efforts from
multiple successful preclinical models.
Le principal problème associé à la curcumine est depuis
toujours sa biodisponibilité. Comme elle est très peu absorbée par le
système sanguin, des doses très élevées sont nécessaires pour obtenir un
effet appréciable. Un changement clé est survenu lorsque les
scientifiques de l’Université de Californie à Los Angeles (UCLA) se sont
penchés sur cette question en privilégiant une perspective différente.
Essentiellement, la question n’est pas de savoir quelle quantité de
curcumine on consomme, mais bien quelle quantité est absorbée par le
système sanguin. Avec le temps, cet axe de recherche a porté ses fruits.
En effet, CurcuMIND n’est pas un supplément de Curcumine comme on en
retrouve habituellement sur le marché. Il s’agit de produits qui offrent
un type avant-gardiste et optimisé de curcumine appelé Longvida, une
percée technologique réalisée par des chercheurs de UCLA s’étant donné
comme objectif d’accroître considérablement la biodisponibilité et
l’absorption de la curcumine. Des études menées chez l’humain ont
démonté que cette technologie augmente le taux d’absorption de la
curcumine d’au moins douze fois, comparativement aux extraits classiques
de curcumine à 95 %.
Comment ça fonctionne? Nanotechnologie visant les particules solides de lipides
Cette avancée technologique est le fruit de dix années de recherches
poussées. Elle consiste en l’incorporation de Curcumine à une matrice
formée d’une particule solide de lipide. Le principe sur lequel repose
cette façon de procéder s’explique par le fait que la curcumine est plus
soluble dans les graisses et les huiles que dans l’eau. En utilisant
une particule solide de lipide, les chercheurs ont été en mesure
d’accroître sa biodisponibilité. Or, cette technologie dépasse largement
la simple dissolution de curcumine dans un système de libération à base
d’huile. En effet, non seulement la matrice contenant la particule
protège la curcumine dans l’environnement hostile de l’estomac, mais on a
aussi établi lors d’essais cliniques qu’elle contribue à augmenter le
taux d’absorption de la curcumine.
CurcuMIND– Un anti-inflammatoire de qualité supérieure
Le produit procure 400 mg de Curcumine et 1000 UI de Vitamine D par
trois capsules, avec un dosage quotidienne recommandé de jusqu’à neuf
capsules (1200mg). Cette dose ultra forte de curcumine s’avère bénéfique
dans les cas d’affections graves, comme les maladies auto-immunes et la
maladie d’Alzheimer. Il importe de ne pas comparer la quantité de
curcumine contenue dans ces produits à celles qu’on retrouve dans les
suppléments traditionnels. Alors que la dose de 1200 mg par jour de
CurcuMIND peut sembler plutôt faible au premier abord, souvenez-vous
qu’il n’est pas question de dose, mais bien de la quantité absorbée. Il a
été démontré que le taux d’absorption de la curcumine optimisée que
contiennent ces produits est 100 fois plus élevé que celui des
suppléments habituels de curcumine.
La biodisponibilité supérieure signifie que CurcuMIND procure
l’équivalent d’au moins 13g d’un extrait courant de Curcumine par
capsule!
La puissance de la curcumine et de la vitamine D
AOR est la première entreprise à combiner la curcumine et la Vitamine D en un seul produit, qui contient donc deux nutriments
hautement bénéfiques dont les effets synergiques s’avèrent avantageux
pour la santé en général, en plus de présenter un potentiel
extraordinaire pour le traitement de diverses affections.
Il a été démontré que la prise d’un supplément de vitamine D avait un
effet positif dans bon nombre d’affections pour lesquelles la curcumine
est bénéfique, comme les troubles inflammatoires et les maladies
auto-immunes, dont la maladie intestinale inflammatoire. En effet, des
études récentes ont mis en évidence l’importance de la Vitamine D dans
la prévention d’un grand nombre de problèmes de santé. On a d’ailleurs
associé une carence en vitamine D à l’apparition de maladies
auto-immunes, d’infections et d’un déclin cognitif. Voilà pourquoi la
vitamine D est un partenaire idéal pour la curcumine, qui, on le sait,
est bénéfique pour les mêmes types d’affections.
En outre, de nouvelles études révèlent des résultats fort prometteurs
liés à l’association de curcumine et deVitamine D dans le traitement
de la maladie d’Alzheimer, car celle-ci permet de réduire la quantité de
plaque amyloïde (facteur clé dans le développement de la maladie) dans
le cerveau. En fait, lors d’expériences menées sur des animaux, on a
observé que la curcumine Longvida augmentait l’élimination de la plaque
amyloïde dans le cerveau plus efficacement que quatre des médicaments
les plus employés pour traiter la maladie d’Alzheimer, et tout ça en
quatre jours!