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AOR, Fem Adapt, 60 vcaps

AOR, Fem Adapt, 60 vcaps is manufactured by AOR Supplements

Last updated on 12/5/2016

Fem Adapt

  • Helps reduce hot flashes and night sweats
  • Provides powerful phytoestrogens
  • Promotes mood balance during menopause
  • Reduces the risk of post-menopausal diseases

Fem Adapt was formulated with the most effective natural substances known to help relieve the symptoms associated with menopause. It is used in herbal medicine to help relieve premenstrual symptoms, including pain associated with menstruation, muscle and joint pain associated with rheumatic conditions (such as rheumatoid arthritis, osteoarthritis and/or fibrositis), pain associated with neuralgia (such as sciatica) and to help ease nervous tension/nervousness (sedative and/or calmative).

Product Code Size Per Capsule Vegetarian
80034694 AOR04002 60 vegi-caps 214 mg Vegetarian
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving

Linum usitatissimum L. extract (80-120:1) 168 mg
Soy Isoflavone Extract - Total isoflavones - Genistein/Genistin 60 mg 14.2 - 18.2 mg  AIE* 8.4 -10.2 mg  AIE*
Black Cohosh extract (15-20:1) 80 mg
LIFENOL® Hops extract (15-25:1)† 120 mg

*AIE: Aglycone Isoflavone Equivalents. †LIFENOL® is a registered trademark of Naturex, Inc. Non-medicinal ingredients: microcrystalline cellulose, silicon dioxide, maltodextrin, tricalcium phosphate.  Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no peanuts, eggs or shellfish.

Adult Dosage: (menopausal and post-menopausal women): Take 2 capsules daily, or as directed by a qualified health care professional. Take a few hours before or after taking other medications or natural health products. Consult a health care practitioner for use beyond one year.

Cautions: Ensure you are up-to-date on mammograms and gynecological evaluations prior to use. Consult a health care practitioner prior to use if you are taking blood thinners, have a history of hormonal or gynecological disease including ovarian cancer, endometriosis or uterine fibroids, have a liver disorder or develop liver-related symptoms (e.g. abdominal pain, jaundice, dark urine), are taking hormone replacement therapy (HRT) including thyroid hormone replacement therapy or have depression or related diseases. Discontinue use and consult a health care practitioner if you experience breast pain, discomfort or tenderness or if you experience a recurrence of menstruation and/or uterine spotting. Do not use if you currently have or previously had breast cancer or breast tumours, have a predisposition to breast cancer as indicated by an abnormal mammogram, biopsy or have a family member with breast cancer. Consumption with alcohol, other medications or natural health products with sedative properties is not recommended. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Hypersensitivity such as an allergy has been known to occur in rare cases, in which case discontinue use. Consult a health care practitioner if symptoms persist or worsen. This product contains soy.

Pregnancy/Nursing: Consult a health care practitioner prior to use if you are breastfeeding. Do not use if you are pregnant.

Natural botanical extracts;
Non-GMO soy

Main Indications:

  • Menopause
  • PMS
  • Women’s health


Background Information

Symptoms of Menopause
Menopause refers to the permanent cessation of ovulation and menstrual periods in women, which can occur either naturally or as a result of medical or surgical intervention. It is a natural physiological event that results in a decreased production of sex hormones – estrogen and progesterone – by the ovaries. The primary symptoms of menopause include hot flashes and night sweats. Secondary symptoms can include anxiety, mood swings, depression, loss of libido and vaginal dryness. Hot flashes are thought to result from a decline in circulating estradiol (E2) that induces a thermoregulatory dysfunction mediated by the hypothalamus.

Hormonal Balance
Studies have shown that phytoestrogens such as lignans from flax and genistein from soy isoflavones have direct effects on some of the hormonal pathways that are involved in menopausal symptoms. This combination may also be effective in reducing the risks of post-menopausal-related osteoporosis, cancer and cardiovascular disease. AOR’s Fem Adapt formula provides safe and effective relief for menopausal symptoms such as hot flashes and night sweats and protection against diseases for which the risk increases after menopause like cardiovascular disease, cancer and osteoporosis.

Hot Flashes and Genistein
In Asia, only 10-20% of menopausal women experience hot flashes, while in North America 70-80% of women experience hot flashes. Researchers have hypothesized that this difference is due to dietary factors, including the consumption of isoflavones found in soy. Genistein is one of the key isoflavones found in soy and has been researched in menopausal women due to its structural similarity to estrogen, making it a phytoestrogen. During menopause the production of estrogen declines which is why genistein has been used, due to its structural similarity to estrogen. Many clinical trials have shown genistein supplementation to reduce the number and severity of hot flashes during menopause.

Black Cohosh
Black Cohosh is a flowering plant native to North America originally used by the Native Americans. It has been traditionally used in herbal medicine for the relief of menstrual-associated pain and the pain associated with neuralgia conditions such as sciatica. It has been effective in relieving the muscle and joint pain associated with rheumatic conditions such as osteoarthritis, fibrositis and rheumatoid arthritis. As it has a calmative effect, it is also useful in nervous conditions. Recent research has found that black cohosh may actually have anti-depressive and anti-osteoporotic activities, which help reduce some of the secondary symptoms associated with menopause.

Lignans, menopause and cancer
Lignans are naturally occurring compounds found in the cell walls of plants such as fruits, vegetables, nuts and seeds such as flax (Linum usitatissimum). They are transformed in the colon to enterodiol and enterolactone which are then absorbed into the body via enterohepatic circulation. Studies show that enterolactone and enterodiol are helpful in conditions associated with estrogen deficiency.
Lignan supplementation has also been shown to increase the production of 2-hydroxyestrogen. Research shows having a higher ratio of 2-hydroxyestrogen to 16α-hydroxyestrogen is protective from estrogen dependent cancers. Enterolactone and enterodiol in clinical trials have been shown in both human and animal models to inhibit tumor growth.

Hops and Estrogen
Lifenol is a patented hops extract which has been clinically studied in France in menopausal women. Hops have been used in the beer industry for hundreds of years but in 1988 one of the active components of hops – 8-prenylnaringenin (8PN) was identified as having estrogenic properties; it is considered the most potent phytoestrogen. 8PN has been shown to have a higher affinity for estrogenic receptors than coumesterol from clover or genistein or dadzein from soy due to a unique side chain.

PMS and Menstrual Migraines
Some of the ingredients in Fem Adapt such as soy isoflavones and black cohosh have also been traditionally used to treat PMS symptoms and have been clinically found to reduce the frequency of migraine attacks associated with menstruation. This makes Fem Adapt helpful for peri-menopausal and menopausal women dealing with the uncomfortable symptoms of hormone fluctuations.


Genistein and Estrogen
Genistein has been shown in laboratories to have estrogenic effects by weakly binding to estrogen receptors (ER). For this reason it is commonly referred to as a phytoestrogen. It binds more strongly to ER-β than ER-α, which then competes with estradiol for binding to these estrogen receptors. The β -estrogen receptor predominates in the heart, vasculature, bone, and bladder and may account for some of genistein’s beneficial effects. Genistein binds weaker to ERs than estradiol, and induces estrogenic effects with less potency than estradiol. This suggests that genistein selectively binds to estrogen receptors, serving as a natural alternative to conventional hormonal therapy, which has been associated with an increased risk of breast cancer, stroke, venous thromboembolism and coronary heart disease.

Genistein and Osteoporosis

Genistein structurally resembles estrogen and acts as a selective estrogen receptor modulator. Genistein may help control bone cell metabolism by its higher affinity for β-estrogen receptors, which are found more in bone than α-estrogen receptors, which are found more in reproductive tissue. Genistein has been shown to directly inhibit osteoclast activity, which is involved in the destruction of bone and increase osteoblastic proliferation, which is involved in bone formation. Studies have shown genistein to decrease bone resorption markers and increase bone formation markers, leading to a net gain in bone mass. These findings have been confirmed using the urinary excretion markers pyridinoline and deoxypyridinoline (markers of bone resorption), which were found to be decreased in research subjects taking genistein. In one clinical trial lasting over two years in duration, subjects supplemented with genistein and experienced an improvement in bone mineral density (BMD), as well as a significant decrease in bone fracture risk.

Flax Lignans
SDG or secoisolariciresinol diglucoside from flax (Linum usitatissimum) is specialized lignan that has high bioavailability due to the monomers compared to the large polymers usually found in traditional flax supplements. SDG is converted by mammalian bacteria in the colon into enterodiol (END) and enterolactone (ENL) which are the active human lignans. These lignans (remarkably similar to the human estrogens) are extensively studied for their cardioprotective, menopausal, bone density and inflammatory effects in humans. A recent study in women using 500mg of SDG for 6 weeks was found to reduce ultra-sensitive C-reactive protein, one of the inflammatory markers. Another study showed that women had significantly reduced cholesterol and atherosclerosis indices when taking SDG monomers. Animal studies have confirmed the benefits of SDG as an anticarcinogen for the breast, colon, ovary and the endometrium tissues. An important finding was that SDG exerts a potent anti-angiogenesis effect particularly by inhibiting the vascular endothelial growth factor (VEGF) and promoting apoptosis. It is also hypothesized that lignans stimulate sex hormone binding globulin (SHBG) from the liver, inhibiting aromatase activity and decreasing cancer cell proliferation.

A double blind randomized cross over study (specifically designed to take into account the high degree of “placebo” effect common with menopausal studies) showed that 8PN reduced hot flashes and night sweats and may be a good adjunct to other post-menopausal treatments.

Black Cohosh
The effects of black cohosh on menopausal symptoms such as hot flashes and night sweats are under scrutiny, as are its traditional uses for pain related to PMS and its content of estrogen-like compounds. However, more recent research has revealed that black cohosh may have serotonin-like compounds that activate serotonin receptors. This is important because low mood and depression can be secondary symptoms to menopause and PMS. In addition, newer clinical studies have shown that compounds in black cohosh may inhibit the formation of osteoclasts which are cells that break down bone. Bone loss is one of the top concerns among post-menopausal women. For these reasons, black cohosh is still considered to be advantageous for menopausal women.

Menstrual Migraines
Several older studies also found some of these ingredients helpful for reducing migraines associated with menstruation. One study found that a blend of the phytoestrogens black cohosh, dong quai and soy isoflavones significantly reduce the frequency of migraine attacks versus placebo from months 2-6. Another study administered genistein and daidzein, two phytoestrogens found in soy isoflavones and found reduced frequency of migraine attacks over 3 months.

Market Trends

Many women turn to conventional hormone therapies to manage physical difficulties experienced during menopause, or to over-the-counter pain killers, anti-inflammatories or birth control pills to alleviate the symptoms of PMS. Unfortunately some of the therapies and medications have undesirable side effects.

There is confusion as to whether phytoestrogens increase the risk of estrogen-dependent cancers. Many recent studies have found that phytoestrogens do not increase the risk and may in fact be protective against various cancers.

AOR Advantage

AOR’s Fem Adapt includes standardized clinically tested natural ingredients that have been demonstrated to safely and effectively alleviate some of the uncomfortable and undesirable symptoms associated with menopause. There is also some evidence to suggest that phytoestrogens, and those from soy in particular, can help alleviate the symptoms of PMS including menstrual migraines.

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