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AOR, D-Glucarate+Milk Thistle, 60 vcaps - AOr D-Glucarate + Milk Thistle contains Milk thistle which helps to support liver function and is used as a liver protectant.
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AOR, D-Glucarate+Milk Thistle, 60 vcaps

AOR D-Glucarate + Milk Thistle - 60 vcaps
D-Glucarate + Milk Thistle - 60 vcaps, aor vitamins supplements
AOR, D-Glucarate+Milk Thistle, 60 vcaps is manufactured by AOR Supplements

Last updated on 12/5/2016

D-Glucarate + Milk Thistle

  •  Supports liver function
  •  Protects cells from carcinogens
  •  Supports normal cell growth
  •  Reduces susceptibility to certain cancers

D-Glucarate + Milk Thistle helps to support liver function and is used as a liver protectant.

NPN Product Code Size Per Capsule Vegetarian
80028143 AOR04272 60 Vegi-Caps 325 mg Vegetarian
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving

 Calcium D-Glucarate 150 mg
 Milk Thistle Dry Extract (80% Silymarin) 175 mg

Non-medicinal ingredients: Capsule: water.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, shellfish, or any animal byproduct.

Adult Dosage: Take 1 capsule twice daily with food, or as directed by a qualified health care professional. Use for a minimum of 3 weeks to see beneficial effects.

Cautions: Consult a health care practitioner prior to use if you are taking other medications or antibiotics, for use beyond 28 days, or if symptoms persist or worsen. Do not use if you have a liver or eye condition, or have Sly disease. Discontinue use if a hypersensitivity develops (such as an allergy) or if symptoms of liver trouble or corneal clouding develop.

Pregnancy/Nursing: Do not take

Source:
Synthesis from glucose; Milk thistle extract

Main Indications:

  • Detoxification
  • Liver health
  • Cellular growth and differentiation

Research

Background Information

D-Glucarate
D-glucarate is a substance made in small amounts by the body but found mainly in foods like oranges and cruciferous vegetables like broccoli. Interestingly enough, such foods also contain other substances that promote detoxification and protect against cancer, including glucoraphanin glucosinolate (SGS), IP6, DIM and I3C. D-Glucarate reduces the activity of the killer beta-glucuronidase enzyme in tissues all over the body, including key organs like the liver, spleen, breast, lung, and prostate resulting in higher net glucuronidation activity. This boost to your body’s glucuronidation capacity helps to ensure that those pollutants and toxins that have been neutralized by UGTs will stay neutralized, and be safely passed out through the urine or the bile.

Every moment of every day, every cell in your body is under attack by chemical and biological weapons with the potential to cause cancer. Carcinogenic compounds include not just artificial chemicals (such as persistent organic pollutants (POPs)) in the form of organochlorine pesticides and other such chemicals), but ancient, and even naturally-occurring, cancer-causing substances, including polycyclic aromatic hydrocarbons (PAH), heterocyclic amines (HCAs), fungal toxins (such as aflatoxin), and even excess levels of the sex hormones estrogen and testosterone.

Glucuronidation: Phase II Detoxification
The body makes use of intricate detoxification pathways to process xenobiotic and naturally occurring toxins. One of the most important of such pathways is glucuronidation, in which UGT enzymes (uridine 5′-diphospho-glucuronosyltransferase) neutralize carcinogens by binding them to a molecule of glucuronic acid. This is an essential part of phase II detoxification. Glucuronidation renders potential carcinogens less hazardous to the cells of the body. It also makes many such chemicals easier for the body to excrete through the urine or the bile. Glucuronidation generally glucuronidates chemical carcinogens, steroid hormones, and other lipid-soluble toxins to either neutralize or detoxify them. The vital neutralization of toxins by glucuronidation can be undone by an enzyme known as beta glucuronidase. This enzyme frees up the original carcinogen from its glucuronic acid “handcuffs.” Beta-glucuronidase is present in the body’s cells and is also produced by some fecal bacteria. The activity of beta-glucuronidase increases with age.

D-Glucarate & Cancer
As you’d expect from a nutrient that is used up in the detoxification process, people exposed to a toxic environment have abnormal levels of D-Glucarate in their tissues and biological fluids. Cancer patients also have disrupted D-Glucarate levels. Impaired glucuronidation has been linked to susceptibility to many cancers and other diseases in humans and in other species. Human research reveals links between toxic environments, glucuronidation, and beta-glucuronidase; and also between glucuronidation, beta-glucuronidase activity, and cancer and other diseases.

Breast Cancer
Studies in animals have found that D-Glucarate supplements provide powerful, effective support for the body’s natural defenses against many kinds of cancer. In one study, giving animals access to D-Glucarate supplements during exposure to the carcinogen DMBA but then had the supplement taken away, the brief intervention still managed to reduce the number of breast tumors the animals formed by 18% compared to animals who never received the supplement. More strikingly, if the scientists waited until the cancerous cells had already formed in the animals, and only then allowed them access to D-Glucarate, breast tumor formation was cut by 42%. And best of all, supplementation began from the first day of chemical exposure, and continued on throughout the study, D-Glucarate cut tumor formation neatly in half. The results of another study were even more impressive: after the animals were exposed to DMBA, those consuming D-Glucarate supplements developed 70% fewer breast tumors than those that did not.

Prostate Cancer
The failure of the glucuronidation machinery is also closely associated with prostate cancer. UGT activity is reduced in prostate cancer cells when they are exposed to high levels of dihydrotestosterone (DHT), the form of testosterone most responsible for promoting prostate cancer. Men with prostate cancer are three times as likely as healthy men to have the gene for a weakened version of the UGT enzyme that glucuronidates DHT. D-Glucarate suppresses the killer betaglucuronidase enzyme in the prostate just as it does in other tissues. Scientists at the AMC Cancer Research center now report that D-Glucarate supplements causes a 30% inhibition of the growth of prostate cancer in animals with existing prostatic tumors.

In addition to these gender-specific cancer threats, scientists have also piled on evidence that D-Glucarate supplementation protects animals against “equal-opportunity” cancers, such as those of the colon, the lung, the skin, and the liver, and have found elevated beta-glucuronidase activity in the tumors of human victims of lung cancer. Beyond supporting the body’s detoxification systems, D-Glucarate supplements also appear to make the cells of the body themselves less prone to carcinogenic stimulation. This property is also shared by milk thistle!

Milk Thistle
Milk thistle has been used for thousands of years in traditional medicine to help treat various liver diseases. Early clinical studies examined its therapeutic effects in alcoholic cirrhosis of the liver, hepatitis, and fibrosis. It is known for protecting the liver and helping the liver self-regenerate after damage, helping to maintain and improve the general functioning of the liver. The liver has many functions, one of which is detoxification. When the liver is functioning optimally, detoxification can occur more efficiently. When any part of the detoxification system is compromised, including liver function, toxins can build-up in the body, causing illness and disease.

Silymarin’s Benefits for the Liver
More recent studies have isolated silymarin, milk thistle’s main active ingredient, which is actually a group of flavonolignans called silybins. These studies are beginning to discover just how powerful silymarin can be. It acts as an antioxidant, protecting cells, especially liver cells, from free-radical damage. It also protects cell membranes from lipid peroxidation, making them more stable and functional thereby protecting the cells.  It might even protect cells by occupying hepatocyte binding sites so that toxins can’t penetrate into the cells. Silymarin stimulates DNA synthesis in hepatocytes, the liver cells, which promotes liver tissue repair and regeneration. Since the liver is where most detoxification happens, it’s important to keep it functioning optimally.

More of Milk Thistle’s Power Revealed
It also helps prevent inflammation in various tissues by inhibiting NF-kB and modulating other pro-inflammatory signals, making it potentially therapeutic in the many illnesses related to inflammation.  Other studies have demonstrated metal-chelating effects of silymarin, including iron and arsenic. Cancer has also been the topic of many silymarin or milk thistle studies lately. One study even found that milk thistle protected both the liver and the heart from chemotherapy damage. Another study found that silymarin actually inhibits tumour cell proliferation in kidney cancer while protecting healthy cells!

Silymarin also appears to benefit metabolic parameters. The results of one study showed significant improvements in various cholesterol and blood sugar parameters such as LDL, triglycerides, fasting blood glucose, HbA1c and others in silymarin treated patients. Another diabetes study found that amyloid protein misfolding and aggregation may be a factor in creating dysfunctional islet cells in the pancreas where insulin is synthesized and excreted from, and that silibinin, a component of milk thistle, can inhibit this misfolding and aggregation! Amyloid aggregation is associated with Alzheimer’s disease, and studies have already had success in reducing the amyloid-beta plaque count using silymarin in animal models of Alzheimer’s disease!

Market Trends

Detoxification products are commonly purchased health supplements. However, not all of these detoxification products are proven to be effective or are backed by genuine scientific evidence. Some of the more common and unproven ways of detoxifying the body are by using foot patches, body wraps and ionic foot baths. Unfortunately, many of the dietary detoxification products on the market are not properly formulated to support the body throughout the detoxification process.

AOR Advantage

Milk thistle and D- Glucarate are backed by extensive clinical research which attests to their benefits in assisting the body with the detoxification process and cellular protection. In combination, these two ingredients provide optimal support to the liver and protect the cells from carcinogens. This product may also be beneficial in reducing the susceptibility to certain cancers and for preventing abnormal cellular growth.


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