AOR Cogni-Q
Pyrroloquinoline Quinone (PQQ) is a recently discovered
B-vitamin-like nutrient that is not practically obtained from food. PQQ
is generally more potent when combined with other strong antioxidants
like Vitamin E or lipoic acid. Both PQQ and Co-enzyme Q10 have been
shown to reduce neurodegeneration and have been shown in studies to
enhance cognitive function in terms of general cognition and memory
while reducing the build-up of amyloid plaque which is responsible for
Alzheimer’s-type dementia. PQQ has also been shown to delay brain
atrophy, that is, the shrinking of the brain, with aging.
| Supplement Facts
|
| Serving Size: 1 Capsule
|
|
Amount Per Serving
|
|
|
| Pyrroloquinoline Quinone*
|
20mg
|
| Co-Enzyme Q-10
|
300mg
|
|
|
| Non-medicinal ingredients: dibasic calcium phosphate, silicon dioxide, microcrystalline cellulose. Capsule: hypromellose, water. *Pyrroloquinoline quinone disodium salt
|
AOR™ guarantees that
no ingredients not listed on the label have been added to the product.
Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish,
shellfish, or any animal byproduct.
Suggested Use: Take 1
capsule per day with food, or as directed by a qualified health care
practitioner. Do not use if pregnant or breastfeeding. Consult a health
care practitioner prior to use if you are taking blood pressure
medication.
Main Application:
- Cognitive Health
- Mitochondrial Function
- Antioxidant
Pregnancy / Nursing:
Do not use if pregnant or breastfeeding
Caution:
Consult a health care practitioner prior to use if you are taking blood pressure medication.
Why PQQ Is Being Called ‘A New Vitamin’
A
vitamin, by definition, is a substance that is required by the body to
carry out essential biochemical functions, and for the most part cannot
be produced endogenously and must be obtained from the diet or
supplements. PQQ's potential status as a vitamin (a B-vitamin to be
precise) is based on its function and structure. It is structurally a
quinone, such a coenzyme Q10. Its discoverers have proposed that it is a
B-vitamin due to the fact that it plays a role in the metabolism of the
essential amino acid lysine, which helps form collagen (essential to
all connective tissues) and aids in the production of antibodies,
hormones & enzymes. The central role common to the B-complex family
of vitamins is the metabolism of proteins, fats and carbohydrates, and
PQQ's involvement in the metabolism of lysine theoretically qualifies it
for that classification, as does its water-solubility. However, PQQ's
potential benefits are certainly not limited to enhancing the body's
ability to process lysine.
A Synergistic Combination
Japanese
researchers have studied the cognitive effects of the PQQ in
combination with CoQ10. Both PQQ and CoQ10 are powerful antioxidants
with beneficial effects for cognition. PQQ has been shown to protect
neurons from toxicity, to enhance nerve growth factor production, to
inhibit free radical damage and to prevent memory deficits related to
free radical damage. Recent studies also show that these benefits are
accentuated by CoQ10. This should come as no surprise given that CoQ10
by itself has been shown to prevent neurodegeneration because of its
effects on the mitochondria. Trials have showed that CoQ10
supplementation delays brain atrophy and the formation of amyloid plaque
in aged animals. Previous trails have also showed that
co-administration of CoQ10 with other substances capable of preventing
mitochondrial damage such as alpha lipoic acid or vitamin E was more
effective than administration of CoQ10 by itself. Studies
also show that CoQ10 may be an effective agent for the treatment and
prevention of Alzheimer’s type dementia. Another important function of
CoQ10 is its role in the production of cellular energy throughout the
body.
In a study where CoQ10 and PQQ, were
used together, participants received 20 mg of PQQ and 300 mg of CoQ10
per day. The effects achieved by this combination were compared to the
effects of CoQ10 by itself. The duration of the study was 12 weeks after
which the patients were put through a battery of tests to assess their
memory and cognitive function. The study was performed in 71 middle-aged
and elderly patients, 22 of which received the PQQ alone, 24 received
the PQQ and CoQ10 and 23 patients comprised the placebo group. No
adverse effects were linked to the supplementation and the results
showed that PQQ had a beneficial effect on cognition and memory, with
the addition of CoQ10 leading to even greater benefits. The results
demonstrated that PQQ, especially when combined with CoQ10 can be used
to improve the mental status and quality of life in older patients. PQQ
also showed great promise for the prevention of age-related decline in
mental status.
Neuroprotection
In response to
a growing aging "first-world" population, the preservation and
enhancement of cognitive function has taken on such a priority that a
proliferative number of natural substances have been developed
exclusively to address this cornerstone field of preventative health.
Many of these substances are herbal in nature, and while effective in
their own right, may not be the equal of vitamins in their natural
propensity to perform a biochemical function, and this is where PQQ may
distinguish itself in this proliferative field. In fact, a double-blind,
placebo-controlled clinical trial was conducted in Japan in 2007 to
measure PQQ's ability to ameliorate the symptoms of age related
cognitive decline. The proprietary study, conducted among healthy men
and women aged between 40 and 70 years, saw the PQQ group outperform the
placebo group by more than twofold in their standardized memory tests.
Even more impressive results were seen when PQQ was combined with
Co-Enzyme Q10.
How It Works
Scientists
believe PQQ's neuroprotective benefits are due mainly to two functions
attributed to it in this area thus far - anti-oxidative activity and
Nerve Growth Factor (NGF) regeneration. The former - in this case - is a
defense against neurotoxicity due to the scavenging of the Reactive
Oxygen Species (ROS) of free radicals in general and superoxide in
particular. In-vitro data has revealed that PQQ was more than 30 times
more effective than Vitamin C or E in this capacity. Nerve Growth Factor
(NGF) is a secreted protein that promotes the growth of peripheral
nerve cells (neurons), and further in-vitro studies have revealed that
PQQ can stimulate the synthesis of NGF by approximately 40-fold.
Mechanism of Action
Closing Thoughts
In
conclusion, while the debate to officially classify Pyrroloquinoline
Quinone (PQQ) as a B-complex vitamin goes on within lofty administrative
and scientific circles, the technology to utilize PQQ in effective
quantities not practically obtained from foods is already here. The
impression PQQ has made in such a short period of time may prove to be a
very promising harbinger of things to come.
AOR Cogni-Q replaces AOR Ortho PQQ. Pyrroloquinoline Quinone -20mg, Co-Enzyme Q-10 - 300mg
Coenzyme Q10
SKU Number: AOR04265
On Sale - AOR Supplements
UPC 0062491704265