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AOR, BCAA, 300gm - Branched Chain Amino Acids are a group of essential amino acids that includes L-leucine, L-isoleucine and L-valine. Studies have shown that these amino acids are involved in protein synthesis.
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AOR, BCAA, 300gm

AOR BCAA - 300gm Powder
BCAA - 300gm Powder, aor vitamins supplements
AOR, BCAA, 300gm is manufactured by AOR Supplements

Last updated on 12/5/2016

BCAA

  •  Enhances muscle recovery and repair post-workout
  •  Helps control blood sugar and insulin
  •  Promotes the use of glucose rather than proteins for energy
  •  Promotes muscle maintenance even without exercise

Branched Chain Amino Acids (BCAA) are a group of essential amino acids that includes L-leucine, L-isoleucine and L-valine. Studies have shown that these amino acids are involved in protein synthesis.

NPN Product Code Size Per Capsule Vegetarian
80023609 AOR04278 300 grams
Vegetarian
Supplement Facts  
Serving Size: 1 scoop (5 g)
 

L-Leucine 2500 mg
L-Isoleucine 1250 mg
L-Valine 1250 mg

Non-medicinal ingredients: lecithin.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, eggs, fish, shellfish, or animal byproduct.

Adult Dosage: Take 1 scoop (5 g) mixed with water or juice daily before a meal, or as directed by a qualified health care practitioner.

Cautions: Consult a health care practitioner for use beyond 90 days, if you have liver or kidney disease, or if you have been instructed to follow a low protein diet.

Pregnancy/Nursing: Do not use

Source:
Pharmaceutical synthesis

Main Indications:

  • Muscle recovery and repair
  • Blood sugar control
  • Mood

Research

Background Information

What are Branched Chain Amino Acids?

Essential amino acids must be obtained through the diet; they cannot be made in the body. Branched chain amino acids (BCAAs) are the most abundant of the essential amino acids. The BCAA category includes three amino acids: leucine, isoleucine and valine. BCAAs make up over a third of essential amino acids in body proteins and about one sixth of the total amino acids in muscle proteins. Since muscle mass makes up about 40% of human body weight, BCAAs play a large role in the human body.

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What do they do?

BCAAs are known to be involved in protein synthesis. BCAAs are unique in that they are metabolized mainly in the muscle, and more specifically in the mitochondria, while most other amino acids are metabolized in the liver. In the mitochondria, BCAAs are oxidized to succinyl-coA and acetyl-coA, providing two potential entry-points into the Kreb’s cycle where ATP, or energy, is made. These two substrates are also involved in other important functions in the body. Research has shown that ingesting BCAAs prior to exercise may inhibit protein breakdown during exercise and optimize protein synthesis post-exercise. BCAA plasma levels peak about 30 minutes after ingestion.

Research

Leucine, in particular, is the most studied of the three BCAAs since it signals the synthesis of protein and glycogen in the muscle (anabolism, or building), and it also appears to modulate the secretion of insulin or its actions on muscle cells. Glycogen is a quick energy supply for working muscles. Post-workout glycogen storage has traditionally thought to be increased only by consuming a good amount of simple carbohydrates immediately post-exercise. Studies have gotten mixed results when examining the effect of combining protein or BCAAs with carbohydrates for elevated post-exercise glycogen synthesis. The more muscle glycogen stores can be increased, the more energy is available for the next exercise session, resulting in better performance. In terms of protein anabolism, the importance of leucine is demonstrated by the fact that when all amino acids are supplemented except leucine, protein synthesis decreases by 40%!

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Isoleucine exerts a hypoglycemic effect that has been observed in humans. It stimulates glucose uptake into the cells and may inhibit glucose synthesis in the liver. This is good news for those with diabetes! Isoleucine also appears to signal glucose usage (catabolism, or breakdown) for energy production in order to spare glycogen and protein from being used to produce energy. This helps to maintain muscle mass and basal fuel levels that help with general muscle function.

Valine may be used to help make glycogen in the liver, thus raising blood glucose levels. Animal studies suggest that valine may enhance fat metabolism.

Regulating Blood Sugar

Since BCAAs seem to have metabolic regulating activities similar to insulin on proteins, carbs and fats, and in regulating blood glucose, some studies have examined their effects related to insulin.

Insulin resistance can be involved in the progression of hepatocellular carcinoma, a type of liver cancer. One study administered 12g BCAAs with an ACE inhibitor for 48 months after curative treatment for hepatocellular carcinoma. Alone, neither treatment was effective in preventing a recurrence of insulin resistance-based HCC, but together, after 3 months, insulin resistance was reduced, and a marker for angiogenesis (growth of blood vessels that feed tumours) was reduced (VEGFR2).

In untrained males, one study administered a drink containing BCAAs, arginine and carbs after a single bout of exhaustive exercise. Glucose and insulin were higher in the test group at 40 and 60 minutes post exercise. Testosterone to cortisol ratio was higher at 120 minutes in the test group, indicating anabolism. Fatigue at 120 mins post-exercise was significantly reduced in the test group.

BCAAs Stimulate Protein Synthesis

Exercise is well known to stimulate protein synthesis and therefore muscle growth. An exciting discovery is that branched chain amino acids can also stimulate protein synthesis, even without exercise! Protein synthesis is thought to be activated by a process called phosphorylation of certain protein enzymes. Exercise and BCAAs can stimulate some of the same enzymes; however, BCAAs can also potentiate the activity of the enzymes activated by exercise as well as activate other enzymes that are not stimulated by exercise.  One study found that leg exercise, when accompanied by BCAA supplementation, activated the enzyme p70(S6k) up to 30-fold in exercising muscle and up to 16-fold even in muscles that were not exercising! The peak activity of these enzymes appears to be between 30-120 minutes post-exercise. One session of exercise did not affect this specific enzyme at all without BCAA supplementation.

Muscle Preservation and Repair

BCAAs have also showed beneficial effects in strength training, including reducing muscle soreness and fatigue and assisting in strength gains. One study showed that consuming a BCAA drink 15 minutes prior to performing repetitive squat exercises shortened the period of peak delayed-onset muscle soreness (DOMS) from days 2 and 3 to only day 2 in the test group, and also lowered the intensity of muscle soreness for 4 days after exercise, particularly in females. There was also a tendency toward less muscle fatigue immediately post-exercise and in the 4 days afterward. Another study administered 4g of leucine per day during a 12-wk strength training program in untrained males. In this study, the test group experienced significantly greater strength gains compared to the placebo group in all 8 exercises, although only 5 were significantly greater.

BCAAs may also be helpful in post-exercise recovery in endurance athletes, better preparing them for a good subsequent performance. One study administered a leucine-rich protein and carbohydrate-rich drink to trained endurance cyclists and found a small improvement in a subsequent bout of high-intensity cycling, reduced overall fatigue, and lower plasma CK levels, possibly indicating reduced muscle damage or faster muscle repair.

Central Factors Related to Fatigue and Mood

Because BCAAs have been found to help reduce perceived overall fatigue, one theory suggests that they may have central effects in the brain on fatigue and mood. One study examined the effects of BCAA as an adjunct treatment for acute mania. Findings suggested that BCAAs may help control manic episodes, probably by competing with tyrosine for uptake into the brain thereby limiting dopamine synthesis. Even more concrete was that the treatment outcomes continued on a positive trend a week after ending the treatment in the BCAA group while the placebo group displayed a regressive trend.

Market Trends

Many people are concerned with maintaining muscle mass and decreasing recovery time periods from exercise, therefore they turn to amino acid supplements to provide their body with an additional energy source.

AOR Advantage

AOR’s BCAA supplement offers a convenient way to get valuable branch chained amino acids into the diet; these are unique in that they are metabolized mainly in the muscle, and more specifically in the mitochondria, while most other amino acids are metabolized in the liver.




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