DISCUSSION:
AOR Advanced Prenatal is the most advanced, balanced, and
comprehensive prenatal supplement available. AOR Prenatal is
formulated with a broad spectrum of vitamins, minerals, and nutrients
whose role in supporting optimal health during pregnancy is backed by
scientific research. Unique features of AOR Prenatal include:
the presence of the complete E-complex, the inclusion of a probiotic,
the formulation of dosages based on published human epidemiology, and
the use of superior forms of nutrients, such as Se-methylselenocysteine
and Menatetrenone.
90 Vegi-Caps
AOR04213
SUPPLEMENT FACTS
Serving Size: 3 capsules
| VITAMINS
|
|
|
Vitamin A Complex
|
|
| Retinol
(palmitate)
|
10mg/2500 IU
|
| Beta-carotene
|
6mg/9990 IU
|
| Vitamin B Complex
|
|
| B1 (Thiamin)
|
9mg
|
| B2 (Riboflavin)
|
2.5g
|
| B3 (Niacin from Inositol Hexanicotinate)
|
18mg
|
| B5 (d-Ca-Pantothenate)
|
12mg
|
| B6 (Pyridoxal-5’-Phosphate)
|
80mg
|
| B12 (Methylcobalamin)
|
647mg
|
| Folic Acid (from 5-methyltetrahydrofolate)
|
800mg
|
| Choline (Bitartrate)
|
100mg
|
| Inositol (from Inositol, Inositol Hexanicotinate)
|
100mg
|
| Vitamin C (Ascorbic Acid)
|
120mg
|
| Vitamin D3 (Cholecalciferol)
|
25mcg/1000 IU
|
|
Vitamin E Complex
|
|
| Tocopherols:
|
100mg
|
| Alpha-tocopherol
|
15mg/22IU
|
| Beta-tocopherol
|
2mg
|
| Gamma-tocopherol
|
60mg
|
| Delta-tocopherol
|
24mg
|
| Tocotrienols:
|
10mg
|
| Alpha-tocotrienol
|
3mg
|
| Beta-tocotrienol
|
0.3mg
|
| Gamma-tocotrienol
|
6mg
|
| Delta-tocotrienol
|
1.3mg
|
| Vitamin K2 (Menatetrenone [MK-4])
|
120mg
|
| Minerals
|
|
| Boron (Citrate)
|
700mcg
|
| Calcium (Citrate-Malate)
|
25mg
|
| Chromium (Picolinate)
|
240mcg
|
| Copper (Citrate)
|
1.3mg
|
| Iodine (Potassium Iodide)
|
290mcg
|
| Iron (SunActive®Fe - ferric pyrophosphate)
|
35mg
|
| Magnesium (Aspartate)
|
25mg
|
| Molybdenum (Na Molybdate)
|
50mcg
|
| Selenium (Se-Methylselenocysteine)
|
55mcg
|
| Silicon (Sodium Metasilicate)
|
84mcg
|
| Zinc (Citrate)
|
13mg
|
|
Probiotics
|
|
| Bifidobacterium Longum (BB536)
|
88mg/7.04 billion organisms
|
Non-medicinal ingredients: microcrystalline
cellulose,
lipid carrier of vitamin D3 in starch-coated matrix of
gum arabic and sucrose. Capsule;
hypromellose,
water.
AOR™ guarantees that no ingredients
not listed on the label have been added to the product. Contains no
wheat, gluten, nuts, eggs, fish, or shellfish.
Suggested use:
Take three capsules daily with
meals, or as directed by a qualified health care practitioner.
Main Applications:
Nutritional support during
pregnancy/nursing
Multivitamin/mineral
Source:
Multi –Sourced
Cautions:
Keep out of reach of children. There is
enough iron in this package to seriously harm a child. Consult a health
care practitioner prior to use if you are taking blood thinners. Do not
use if you are experiencing nausea, fever, vomiting, bloody diarrhoea
or severe abdominal pain. Do not use if you have an immune-compromised
condition (e.g. AIDS, lymphoma, patients undergoing long-term
corticosteroid treatment).
Pregnacy/Nursing:
Safe at recommended dose
*These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure,
or prevent any disease. The information and product descriptions
appearing on this website are for information purposes only, and are not
intended to provide medical advice to individuals. Consult with your
physician if you have any health concerns, and before initiating any new
diet, exercise, supplement, or other lifestyle changes. Any
reproduction in whole or part and in print or electronic form without
express permission is strictly forbidden. Permission to reproduce
selected material may be granted by contacting AOR Inc.
Superior Support from Preconception to Nursing
Nutritional
deficiencies are common during pregnancy. Proper nutritional support is
essential before conception, during pregnancy, and while nursing. The
developing baby has specific nutritional requirements, and inadequate
supplies of these nutrients can have damaging effects on the child as
well as leading to potentially harmful deficiencies in the mother.
Advanced Prenatal provides essential vitamins and minerals in superior
forms and in doses appropriate for pregnancy.
The
fetus is dependent on the maternal supply of nutrients. During
gestation, the maternal dietary intake is of utmost importance to
support growth during the prenatal period. Studies have demonstrated
that inadequate growth throughout gestation influences long-term health
in the infant, leading to increases in the risk of Type 2 diabetes,
hypertension and several other diseases later in life. Proper nutrition
before conception is also important, as this is a time where nutritional
stores can be built up to help prevent deficiencies during pregnancy.
Key
Nutrients during Pregnancy
Vitamin
B Complex – B Vitamins have a wide-range of functions
during pregnancy. Vitamin B3 can help protect the developing brain from
damage from toxins like alcohol. Vitamin B6 helps reduce nausea during
morning sickness. Vitamin B12, folic acid, choline and inositol are all
play a vital role in normal brain development and in the prevention of
neural tube defects. Choline is also essential later in pregnancy and
during nursing to promote healthy neurological development. Vitamin B1
levels during the third trimester can influence breast milk quality, and
both B1 and B6 have been shown to help reduce leg cramps.
Vitamin
D – Vitamin D is essential for bone development
and better vitamin D intake during pregnancy has also been linked to a
reduced risk of immune disorders such as multiple sclerosis rheumatoid
arthritis and chronic disease susceptibility later in life. It has been
hypothesized that low prenatal vitamin D can increase the risk for
cancer, schizophrenia, insulin dependent diabetes, immune disorders and
other adult health outcomes.
Iron
- Studies have shown that anemia affects 50-70% of women during
pregnancy. Infants are especially susceptible to iron deficiency because
of the rapid growth they undergo which explains why iron requirements
during pregnancy almost double. Infants with inadequate iron status
scored six to15 points lower on mental development test scores; six to
17 points lower on motor test scores, had poorer locomotor skills and
had longer looking times on visual recognition memory tests.
Probiotics
– Supplementation with probiotics during pregnancy can
help to support the immune system, and has been associated with a
reduced risk of atopy and allergies in the infant. Probiotics also help
to promote healthy gut flora and gastrointestinal health.
Other
Nutrients – Other vitamins and nutrients are important
during pregnancy. For example vitamin C in breast milk has been linked
to a reduce risk of atopic disease. Vitamin E, particularly
gamma-tocopherol may help to reduce preeclampsia. Minerals like calcium,
magnesium and silicon are also important to support bone development
and to protect the bones of the mother.
A
Safe and Balanced Formula
A
primary concern with any prenatal formula is that it will not harm the
developing baby. Advanced Prenatal contains nutrients and minerals in
doses and forms that have been shown to be safe for pregnant women and
for the developing fetus, while still providing optimal nutritional
support.
Superior
Prenatal Supplementation
Pregnancy
is a time of high metabolic demands. Gestation is a crucial
developmental period where inadequate supply of essential nutrients will
negatively affect long-term health in the newborn and compromise
maternal well-being. The health of the mother and child are dependent
on the maternal nutritional status as is the quality of the breast
milk. After all, pregnancy and lactation are developmental periods
where mom is eating for two. Advanced Prenatal provides the vitamins and
minerals essential for pregnancy, helping to improve nutritional status
and to support the health of mother and baby during this critical time.
References
Godfrey
KM, Barker DJ. Fetal nutrition and adult disease. Am J Clin Nutr. 2000 May;71(5 Suppl):1344S-52S
Tamura
T, Picciano MF. Folate and human reproduction. Am J Clin Nutr
2006;83:993-1016
Ray
JG, Laskin CA. Folic
acid and homocyst(e)ine metabolic defects and the risk of placental
abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic
review. Placenta. 1999 Sep;20(7):519-29.
Chaudhuri
A. Why we should offer
routine vitamin D supplementation in pregnancy and childhood to prevent
multiple sclerosis. Med
Hypotheses.
2005;64(3):608-18.
Hollis
BW, Wagner CL. Nutritional vitamin D status during
pregnancy: reasons for concern. CMAJ. 2006 Apr
25;174(9):1287-90
Ieraci
A, Herrera DG. Nicotinamide protects against
ethanol-induced apoptotic neurodegeneration in the developing mouse
brain. PLoS Med. 2006 Apr;3(4):e101.
Vutyavanich
T, Wongtra-ngan S, Ruangsri R. Pyridoxine for nausea and vomiting of
pregnancy: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 1995 Sep;173(3 Pt 1):881-4
Cavalli P, Copp
AJ. Inositol and folate
resistant neural tube defects. J
Med Genet. 2002 Feb;39(2):E5.
Steen
MT, Boddie AM, Fisher AJ, Macmahon W, Saxe D, Sullivan KM, Dembure PP,
Elsas LJ. Neural-tube defects are
associated with low concentrations of cobalamin (vitamin B12) in
amniotic fluid. Prenat Diagn. 1998 Jun;18(6):545-55.
Zeisel
SH. Choline, homocysteine, and
pregnancy. Am J Clin Nutr. 2005 Oct;82(4):719-20.
Fetal
nutrition and adult disease.
Godfrey
KM, Barker DJ. Am J Clin Nutr. 2000 May;71(5 Suppl):1344S-52S
Recent
research suggests that several of the major diseases of later life,
including coronary heart disease, hypertension, and type 2 diabetes,
originate in impaired intrauterine growth and development. These
diseases may be consequences of "programming," whereby a stimulus or
insult at a critical, sensitive period of early life has permanent
effects on structure, physiology, and metabolism. Evidence that coronary
heart disease, hypertension, and diabetes are programmed came from
longitudinal studies of 25,000 UK men and women in which size at birth
was related to the occurrence of the disease in middle age. People who
were small or disproportionate (thin or short) at birth had high rates
of coronary heart disease, high blood pressure, high cholesterol
concentrations, and abnormal glucose-insulin metabolism. These relations
were independent of the length of gestation, suggesting that
cardiovascular disease is linked to fetal growth restriction rather than
to premature birth. Replication of the UK findings has led to wide
acceptance that low rates of fetal growth are associated with
cardiovascular disease in later life. Impaired growth and development in
utero seem to be widespread in the population, affecting many babies
whose birth weights are within the normal range. Although the influences
that impair fetal development and program adult cardiovascular disease
remain to be defined, there are strong pointers to the importance of the
fetal adaptations invoked when the maternoplacental nutrient supply
fails to match the fetal nutrient demand.
Folic
acid and homocyst(e)ine metabolic defects and the risk of placental
abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic
review.
Ray
JG, Laskin CA.
Placenta. 1999 Sep;20(7):519-29.
Placental
infarction or abruption, recurrent pregnancy loss and pre-eclampsia are
thought to arise due to defects within the placental vascular bed.
Deficiencies of vitamin B12 and folate, or other abnormalities within
the methionine-homocyst(e)ine pathway have been implicated in the
development of such placental diseases. We conducted a systematic
literature review to quantify the risk of placental disease in the
presence of these metabolic defects. Studies were identified through
OVID Medline between 1966 and February 1999. Terms relating to the
measurement of vitamin B12, folic acid, methylenetetrahydrofolate
reductase or homocyst(e)ine were combined with those of pre-eclampsia,
placental abruption/infarction or spontaneous and habitual abortion.
Human studies comprising both cases and controls and published in the
English language were accepted. Their references were explored for other
publications. Data were abstracted on the matching of cases with
controls, the mean levels of folate, B12 or homocyst(e)ine in each group
or the frequency of the homozygous state for the thermolabile variant
of methylenetetrahydrofolate reductase. The definition of 'abnormal' for
each exposure was noted and the presence or absence of the exposure of
interest for each outcome was calculated as an absolute rate with a 95
per cent confidence interval. The crude odds ratios were calculated for
each study and then pooled using a random effects model. Eighteen
studies were finally included. Eight studies examined the risk of
placental abruption/infarction in the presence of vitamin B12 or folate
deficiency, or hyperhomocyst(e)inaemia. Folate deficiency was a
prominent risk factor for placental abruption/infarction among four
studies, though not statistically significant (pooled odds ratio 25.9,
95 per cent CI 0.9-736.3). Hyperhomocyst(e)inaemia was also associated
with placental abruption/infarction both without (pooled odds ratio 5.3,
95 per cent CI 1.8-15.9) and with methionine loading (pooled odds ratio
4.2, 95 per cent CI 1.2-15.0), as was the homozygous state for
methylenetetrahydrofolate reductase (pooled odds ratio 2.3, 95 per cent
CI 1.1-4.9). Vitamin B12 deficiency was not a demonstrable risk factor.
Eight studies examined blood levels among women with spontaneous
abortion or recurrent pregnancy loss. The pooled odds ratios were 3.4
(95 per cent CI 1.2-9.9) for folate deficiency, 3.7 (95 per cent CI
0.96-16.5) for hyperhomocyst(e)inaemia following methionine challenge,
and 3.3 (95 per cent CI 1.2-9.2) for the methylenetetrahydrofolate
reductase mutation. Five case-control studies examined the relationship
between pre-eclampsia and abnormal levels of vitamin B12, folate,
homocyst(e)ine or methylenetetrahydrofolate reductase. Folate deficiency
was not an associated risk factor (odds ratio 1.2, 95 per cent CI
0.5-2.7), but hyper-homocyst(e)inaemia was (pooled odds ratio 20.9, 95
per cent CI 3.6-121.6). Similarly, homozygosity for the
methylenetetrahydrofolate reductase thermolabile variant was associated
with a moderate risk of preeclampsia (odds ratio 2.6, 95 per cent CI
1.4-5.1). Some pooled data were associated with significant statistical
heterogeneity, however. There is a general agreement among several
observational studies that folate deficiency, hyperhomocyst(e)inaemia
and homozygosity for the methylenetetrahydrofolate reductase
thermolabile variant are probable risk factors for placenta-mediated
diseases, such as pre-eclampsia, spontaneous abortion and placental
abruption. Vitamin B12 deficiency is less well defined as an important
risk factor. Due to the limited quality of these data, including
insufficient matching of cases with controls, and possible laboratory
measurement bias relating to pregnancy, prospective studies are needed
to confirm these findings and guide future preventative and therapeutic
research. Copyright 1999 Harcourt Publishers Ltd.
Why
we should offer routine vitamin D supplementation in pregnancy and
childhood to prevent multiple sclerosis.
Chaudhuri
A. Med Hypotheses. 2005;64(3):608-18.
Multiple
sclerosis (MS) is a demyelinating disease of the central nervous system
that runs a chronic course and disables young people. The disease is
more prevalent in the geographic areas that are farthest from the
equator. No form of treatment is known to be effective in preventing MS
or its disabling complications. A number of epidemiological studies have
shown a protective effect of exposure to sunlight during early life and
a recent longitudinal study confirmed that vitamin D supplementation
reduced life-time prevalence of MS in women. Very little is known
regarding the role of vitamin D on the developing brain but experimental
data suggest that cerebral white matter is vitamin D responsive and
oligodendrocytes in the brain and spinal cord and express vitamin D
receptors. It is possible that differentiation and axonal adhesion of
oligodendrocytes are influenced by vitamin D level during brain
development and a relative lack of vitamin D may increase
oligodendroglial apoptosis. The age effect of migration on
susceptibility to develop MS could be explained by a role of vitamin D
on brain development. In areas of high MS prevalence, dietary
supplementation of vitamin D in early life may reduce the incidence of
MS. In addition, like folic acid, vitamin D supplementation should also
be routinely recommended in pregnancy. Prevention of MS by modifying an
important environmental factor (sunlight exposure and vitamin D level)
offers a practical and cost-effective way to reduce the burden of the
disease in the future generations.
Pyridoxine
for nausea and vomiting of pregnancy: a randomized, double-blind,
placebo-controlled trial.
Vutyavanich
T, Wongtra-ngan S, Ruangsri R. Am J Obstet Gynecol. 1995 Sep;173(3 Pt 1):881-4
OBJECTIVE:
Our purpose was to determine the effectiveness of pyridoxine for nausea
and vomiting of pregnancy. STUDY DESIGN: During an 11-month period 342
women who first attended Chiang Mai University Hospital antenatal clinic
at < or = 17 weeks' gestation were randomized to received either
oral pyridoxine hydrochloride, 30 mg per day, or placebo in a
double-blind fashion. Patients graded the severity of their nausea by a
visual analog scale and recorded the number of vomiting episodes over
the previous 24 hours before treatment and again during 5 consecutive
days on treatment. RESULTS: There was a significant decrease in the mean
of posttherapy minus baseline nausea scores in the pyridoxine compared
with that in the placebo group (t test, p = 0.0008). There was also a
greater reduction in the mean number of vomiting episodes, but the
differences did not reach statistical significance (p = 0.0552).
CONCLUSION: Pyridoxine is effective in relieving the severity of nausea
in early pregnancy.
Prevalence
of iron deficiency in the United States.
Looker
AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL. JAMA. 1997 Mar 26;277(12):973-6.
OBJECTIVE:
To determine the prevalence of iron deficiency and iron deficiency
anemia in the US population. DESIGN: Nationally representative
cross-sectional health examination survey that included venous blood
measurements of iron status. MAIN OUTCOME MEASURES: Iron deficiency,
defined as having an abnormal value for at least 2 of 3 laboratory tests
of iron status (erythrocyte protoporphyrin, transferrin saturation, or
serum ferritin); and iron deficiency anemia, defined as iron deficiency
plus low hemoglobin. PARTICIPANTS: A total of 24,894 persons aged 1 year
and older examined in the third National Health and Nutrition
Examination Survey (1988-1994). RESULTS: Nine percent of toddlers aged 1
to 2 years and 9% to 11% of adolescent girls and women of childbearing
age were iron deficient; of these, iron deficiency anemia was found in
3% and 2% to 5%, respectively. These prevalences correspond to
approximately 700,000 toddlers and 7.8 million women with iron
deficiency; of these, approximately 240,000 toddlers and 3.3 million
women have iron deficiency anemia. Iron deficiency occurred in no more
than 7% of older children or those older than 50 years, and in no more
than 1% of teenage boys and young men. Among women of childbearing age,
iron deficiency was more likely in those who are minority, low income,
and multiparous. CONCLUSION: Iron deficiency and iron deficiency anemia
are still relatively common in toddlers, adolescent girls, and women of
childbearing age.
Thiamin
status during the third trimester of pregnancy and its influence on
thiamin concentrations in transition and mature breast milk.
Prentice
et al, 1983 in: Ortega
RM, Martinez RM, Andres P, Marin-Arias L, Lopez-Sobaler AM. Br J Nutr. 2004 Jul;92(1):129-35.
Thiamin
deficiency remains an important public health problem in some
populations. The aim of the present investigation was to study thiamin
status during the third trimester of pregnancy and its influence on the
concentration of this vitamin in transition (days 13-14 of lactation)
and mature breast milk (day 40 of lactation) in a group of Spanish
women. The pregnancies and lactation periods of fifty-one healthy women
18-35 (mean 26.7 (SD 3.7)) years old were monitored. Vitamin intake
during the third trimester was determined by recording the consumption
of foods over 5 d and of the quantities provided by dietary supplements.
Thiamin status during this stage of pregnancy was determined by
measuring the activation coefficient of erythrocyte transketolase
(alpha-ETK). Milk thiamin content was estimated (in 41% of the subjects)
by oxidizing thiamin to thiocrome and measuring fluorescence. Subjects
with thiamin intakes above that recommended (group H) had more
satisfactory serum alpha-ETK coefficients (1.01 (SD 0.19)) than did
those with lower intakes (group L) (1.21 (SD 0.30); P<0.05). Mature
milk thiamin concentrations were significantly higher in group H
subjects (0.59 (SD 0.44) micromol/l) than group L subjects (0.25 (SD
0.07) micromol/l). Subjects with alpha-ETK coefficients >1.25 in the
third trimester had significantly lower mature milk thiamin
concentration (0.31 (SD 0.10) micromol/l) than did subjects with more
satisfactory alpha-ETK levels at this time (0.55 (SD 0.42) micromol/l;
P<0.05). The thiamin status of women can be improved since 25.5% of
subjects took less than that recommended and 13.7% showed signs of
severe deficiency (alpha-ETK >1.25). The influence of maternal
thiamin intake on alpha-ETK coefficients and on mature breast milk
thiamin concentration is confirmed.