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AOR, ALCAR,120 caps - AOR ALCAR is N-acetyl-L-carnitine, which is an acetylated form of L-carnitine, a naturally occurring derivative of the amino acid lysine. AOR ALCAR readily crosses the blood-brain barrier and is an antioxidant for the maintenance of good health.
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AOR, ALCAR,120 caps

AOR ALCAR - 120 vcaps
ALCAR - 120 vcaps, aor vitamins supplements
AOR, ALCAR,120 caps is manufactured by AOR Supplements

Last updated on 12/5/2016

ALCAR

  •  Acetylated form of L-carnitine
  •  Crosses the blood-brain barrier
  •  Provides cognitive support in neurological dysfunction
  •  Provides energy in fatigue syndromes

ALCAR is N-acetyl-L-carnitine, which is an acetylated form of L-carnitine, a naturally occurring derivative of the amino acid lysine. ALCAR readily crosses the blood-brain barrier and helps to reduce fatigue, support cognitive function in the elderly, maintain cognitive function during aging and even relieve pain associated with diabetic neuropathy.

NPN Product Code Size Per Capsule Vegetarian
80039706 AOR04271 120 Vegi-Caps 500 mg Vegetarian
Supplement Facts
Serving Size: 1 Capsule


N-Acetyl-L-Carnitine (HCl) 500 mg

Non-medicinal ingredients: microcrystalline cellulose, silicon dioxide. Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish, or any animal byproduct.

Adult Dosage: Take 2-4 capsules daily with food, or as directed by a healthcare practitioner. A minimum of 3 months may be required before observing an effect.

Cautions: This product provides 1.59 g of single amino acid per day. Consult a health care practitioner prior to use if you are pregnant or breastfeeding, have liver or kidney disease, have been instructed to follow a low protein diet, if symptoms persist or worsen or for use beyond 6 months. Feelings of overstimulation and/or sleeplessness may occur, in which case discontinue use if symptoms persist or worsen. Low incidence of seizures has been reported with oral doses in individuals with or without a pre-existing seizure disorder. Mild gastrointestinal symptoms (transient nausea, vomiting, abdominal cramps and diarrhea) have been reported. Body odor, flatulence, increased appetite or rash may occur.

Pregnancy/Nursing: Consult a health care practitioner before use

Source:
Pharmaceutical synthesis

Main Indications:

  • Cognitive Support
  • Neurological Health
  • Chronic Fatigue

Research

Background Information

Why Carnitine?

L-carnitine itself an amino acid synthesized by the body or obtained from red meat – particularly lamb.  L-carnitine deficiency is thus quite common among vegetarians or those who avoid red meat. L-carnitine plays a central role in the breakdown of long-chain fatty acids and their transport into the mitochondria for oxidation and use in the production of cellular energy.  This makes L-carnitine essential to maintaining a healthy metabolism, which is critical for avoiding many age and lifestyle-associated disorders like Metabolic Syndrome, Type II diabetes, cardiovascular disease, and others.

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ALCAR vs. L-Carnitine

ALCAR is N-acetyl levocarnitine, an acetylized ester of the amino acid L-carnitine. This ester is capable of crossing the blood-brain barrier and neural cell membranes more readily than conventional L-carnitine. It has been suggested that ALCAR is a more bioavailable form of L-carnitine, and also has cognitive benefits associated with it that are not attributed to regular L-carnitine.

ALCAR for Brain and Neuronal Support

Acetyl-L-Carnitine (ALCAR) is a key mitochondrial metabolite needed by these cellular “power plants” to drive nerve cell metabolism. ALCAR helps shuttle fatty acids into the mitochondrial furnaces for burning, and maintains youthful levels of cardiolipin, a unique phospholipid required for mitochondrial bioenergetics. It is for that reason that N-acetyl levocarnitine has been extensively studied for its efficacy in addressing the symptoms of numerous forms of neurological dysfunction, including Alzheimer’s disease, dementia and Down’s syndrome. However, young healthy minds have also been clinically shown to benefit from ALCAR’s effects.

ALCAR is beneficial for people of all walks of life including the young, middle-aged and elderly, vegetarians, brain rehab patients, and the list goes on. Better yet, the positive cognitive effects seem to persist after ceasing short-term supplementation!  This makes it a worthwhile investment with good returns for anyone looking for additional cognitive, metabolic and general health support.

ALCAR Combined with R(+)-Lipoic Acid

ALCAR is best combined with R(+)-lipoic acid. R(+)-Lipoic Acid improves the efficiency of mitochondrial function, while preventing the age-related increase in free radical production which is exacerbated when ALCAR is taken alone.

Research

Support for Alzheimer’s Symptoms

Numerous documented studies among Alzheimer’s patients have reported some encouraging results, particularly with regards to the improved ability of the subjects to perform tasks requiring attention and concentration. In fact, in an early double-blind, placebo-controlled study of 130 patients clinically diagnosed with Alzheimer’s disease receiving ALCAR, a slower rate of deterioration was observed in 13 of 14 outcome measures at the end of the one-year study. These measures included intelligence, long-term verbal memory and selective attention. More recent studies have followed this trend, leading researchers to debate ALCAR’s precise mechanism of action. While most contend that it improves neural cell efficiency, some have speculated that it has the ability to prolong the longevity of cerebral nerve cells. There is also research suggesting that ALCAR enhances Nerve Growth Factor (NGF), a protein that stimulates the growth of nerve cells.

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Support for Young, Healthy Brains

Numerous controlled clinical trials attest to its use in a variety of cognitive disorders and in brain function in young, healthy adults; the standard dose is from 1500 to 3000 milligrams per day. One study on 1.5g of ALCAR supplementation in young adult subjects aged 22-27 for 1 month found that test subjects had better reflexes than controls to an auditory stimulus, and test subjects also demonstrated 3-4 times greater efficiency in navigating a video-game maze than controls.

ALCAR for the Elderly and Fatigued

In a double-blind, placebo-controlled 6-month study on elderly subjects in their 70s complaining of fatigue and having chronic fatigue symptoms, ALCAR administered at 2g twice daily was found to significantly improve physical fatigue, muscle pain, post-exercise fatigue, mental fatigue, the severity of the fatigue, sleep disorders, cognitive functions (measured by a MMSE, or mini mental state examination), chronic fatigue symptoms such as headache, sore throat, painful lymph nodes and joints, and overall functional status.

ALCAR for CVA Rehabilitation

ALCAR enhances rehabilitation following acute cerebral circulatory insufficiency compared with a placebo. Significant differences between the drug and placebo were found in memory, number and word tests and in the responses to simple stimuli and the performance of the maze test.

ALCAR for the Metabolic Syndrome

A 6 month pilot study on non-diabetic subjects at risk for decreased insulin sensitivity measuring the effects of taking 2g/day of oral ALCAR found improvements in systolic blood pressure, insulin sensitivity, glucose tolerance and hypoadiponectinemia (adiponectin is a protein hormone that helps regulate glucose and is inversely correlated to the risk of metabolic syndrome). Such improvements occurred only in those whose measures were further from the norm. Type 2 diabetics are theorized to use more fat than carbohydrates as energy substrates due to impaired pyruvate dehydrogenase activity and increased b-oxidation which is thought to cause insulin resistance and impaired glucose tolerance. Chronic acetyl-L-carnitine supplementation might correct the unbalance of substrate utilization by modulating the expression of glycolytic and gluconeogenic enzymes. It would also ameliorate mitochondrial glucose oxidation, acting as a transport molecule for free fatty acids and as an important acetyl-group donor in high-energy metabolism and free fatty acid b-oxidation.

The ALCAR Treatment Effect Persists

One single-blind clinical trial found that significant effects, such as improved emotional-affective and relational behavior as well as cognitive performance such as memory, persisted after 1 month of ceasing the 3-month testing period of 1500mg of ALCAR per day.

ALCAR Combined with R(+)-Lipoic Acid

The appropriate dose of R(+)-Lipoic Acid for use in combination with ALCAR is 500 milligrams and up. In recent animal experiments, Drs. Bruce Ames and Tory Hagen demonstrated that the ALCAR/ R(+)-Lipoic Acid “stack” reverses much age-associated memory loss, and the underlying brain mitochondrial decay and RNA/DNA oxidation.

Market Trends

Acetyl-L-Carnitine is typically known to be a better absorbed form of L-Carnitine that is mostly used for brain health, while regular L-Carnitine tends to be known as a weight loss supplement.

AOR Advantage

AOR offers products for both L-Carnitine and ALCAR. Take your pick! However, have a good look at the clinical evidence for both products to dispel any myths regarding differences in usage and absorption.


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